Extracellular Matrix in Breast Cancer Invasion

2001 ◽  
Author(s):  
Vito Quaranta
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Invasion ◽  
Breast Cancer Invasion

scholarly journals TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Maren Hülsemann ◽  
Colline Sanchez ◽  
Polina V. Verkhusha ◽  
Vera Des Marais ◽  
Serena P. H. Mao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Cancer Invasion ◽  
Matrix Degradation ◽  
Invasion And Metastasis ◽  
Extracellular Matrix Degradation ◽  
Breast Cancer Invasion ◽  
Membrane Type

AbstractDuring breast cancer metastasis, cancer cell invasion is driven by actin-rich protrusions called invadopodia, which mediate the extracellular matrix degradation required for the success of the invasive cascade. In this study, we demonstrate that TC10, a member of a Cdc42 subfamily of p21 small GTPases, regulates the membrane type 1 matrix metalloproteinase (MT1-MMP)-driven extracellular matrix degradation at invadopodia. We show that TC10 is required for the plasma membrane surface exposure of MT1-MMP at these structures. By utilizing our Förster resonance energy transfer (FRET) biosensor, we demonstrate the p190RhoGAP-dependent regulation of spatiotemporal TC10 activity at invadopodia. We identified a pathway that regulates invadopodia-associated TC10 activity and function through the activation of p190RhoGAP and the downstream interacting effector Exo70. Our findings reveal the role of a previously unknown regulator of vesicular fusion at invadopodia, TC10 GTPase, in breast cancer invasion and metastasis.

Extracellular matrix anisotropy in breast cancer invasion and metastasis

2016 ◽  
Vol 61 ◽  
pp. S102
Author(s):  
D. Park ◽  
R. Jenkins ◽  
A. Labernadie ◽  
E. Wershof ◽  
X. Trepat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Invasion ◽  
Invasion And Metastasis ◽  
Breast Cancer Invasion
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