scholarly journals Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion

2011 ◽  
Vol 13 (6) ◽  
Author(s):  
Bernadette C Victor ◽  
Arulselvi Anbalagan ◽  
Mona M Mohamed ◽  
Bonnie F Sloane ◽  
Dora Cavallo-Medved
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Inflammatory Breast Cancer ◽  
Cathepsin B ◽  
Cancer Invasion ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation ◽  
Breast Cancer Invasion

scholarly journals TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Maren Hülsemann ◽  
Colline Sanchez ◽  
Polina V. Verkhusha ◽  
Vera Des Marais ◽  
Serena P. H. Mao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Cancer Invasion ◽  
Matrix Degradation ◽  
Invasion And Metastasis ◽  
Extracellular Matrix Degradation ◽  
Breast Cancer Invasion ◽  
Membrane Type

AbstractDuring breast cancer metastasis, cancer cell invasion is driven by actin-rich protrusions called invadopodia, which mediate the extracellular matrix degradation required for the success of the invasive cascade. In this study, we demonstrate that TC10, a member of a Cdc42 subfamily of p21 small GTPases, regulates the membrane type 1 matrix metalloproteinase (MT1-MMP)-driven extracellular matrix degradation at invadopodia. We show that TC10 is required for the plasma membrane surface exposure of MT1-MMP at these structures. By utilizing our Förster resonance energy transfer (FRET) biosensor, we demonstrate the p190RhoGAP-dependent regulation of spatiotemporal TC10 activity at invadopodia. We identified a pathway that regulates invadopodia-associated TC10 activity and function through the activation of p190RhoGAP and the downstream interacting effector Exo70. Our findings reveal the role of a previously unknown regulator of vesicular fusion at invadopodia, TC10 GTPase, in breast cancer invasion and metastasis.

scholarly journals Faciogenital Dysplasia Protein Fgd1 Regulates Invadopodia Biogenesis and Extracellular Matrix Degradation and Is Up-regulated in Prostate and Breast Cancer

2009 ◽  
Vol 69 (3) ◽  
pp. 747-752 ◽  
Author(s):  
Inmaculada Ayala ◽  
Giada Giacchetti ◽  
Giusi Caldieri ◽  
Francesca Attanasio ◽  
Stefania Mariggiò ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation ◽  
Faciogenital Dysplasia

scholarly journals Controlled Extracellular Matrix Degradation in Breast Cancer Tumors Improves Therapy by Trastuzumab

2011 ◽  
Vol 19 (3) ◽  
pp. 479-489 ◽  
Author(s):  
Ines Beyer ◽  
Zongyi Li ◽  
Jonas Persson ◽  
Ying Liu ◽  
Ruan van Rensburg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Matrix Degradation ◽  
Extracellular Matrix Degradation
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