EGF-Receptor Signaling in Endocytosis Deficient Cells

2001 ◽  
Author(s):  
Brian Ceresa ◽  
Sandra L. Schmid
Keyword(s):  
Egf Receptor ◽  
Receptor Signaling

scholarly journals Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal  -Cell Growth

Diabetes ◽  
2006 ◽  
Vol 55 (12) ◽  
pp. 3299-3308 ◽  
Author(s):  
P. J. Miettinen ◽  
J. Ustinov ◽  
P. Ormio ◽  
R. Gao ◽  
J. Palgi ◽  
...  
Keyword(s):  
Cell Growth ◽  
Pancreatic Islets ◽  
Egf Receptor ◽  
Receptor Signaling

scholarly journals Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways

2004 ◽  
Vol 24 (2) ◽  
pp. 796-808 ◽  
Author(s):  
Lindsay K. MacDougall ◽  
Mary Elizabeth Gagou ◽  
Sally J. Leevers ◽  
Ernst Hafen ◽  
Michael D. Waterfield
Keyword(s):  
Drosophila Melanogaster ◽  
Signaling Pathways ◽  
Egf Receptor ◽  
Adaptor Protein ◽  
Class Ii ◽  
Notch Receptor ◽  
Mitogen Activated Protein Kinase ◽  
Class I ◽  
Wing Venation ◽  
Receptor Signaling

ABSTRACT Phosphoinositide 3-kinases (PI3Ks) can be divided into three distinct classes (I, II, and III) on the basis of their domain structures and the lipid signals that they generate. Functions have been assigned to the class I and class III enzymes but have not been established for the class II PI3Ks. We have obtained the first evidence for a biological function for a class II PI3K by expressing this enzyme during Drosophila melanogaster development and by using deficiencies that remove the endogenous gene. Wild-type and catalytically inactive PI3K_68D transgenes have opposite effects on the number of sensory bristles and on wing venation phenotypes induced by modified epidermal growth factor (EGF) receptor signaling. These results indicate that the endogenous PI3K_68D may act antagonistically to the EGF receptor-stimulated Ras-mitogen-activated protein kinase pathway and downstream of, or parallel to, the Notch receptor. A class II polyproline motif in PI3K_68D can bind the Drk adaptor protein in vitro, primarily via the N-terminal SH3 domain of Drk. Drk may thus be important for the localization of PI3K_68D, allowing it to modify signaling pathways downstream of cell surface receptors. The phenotypes obtained are markedly distinct from those generated by expression of the Drosophila class I PI3K, which affects growth but not pattern formation.

scholarly journals Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells

Oncogene ◽  
2005 ◽  
Vol 25 (5) ◽  
pp. 735-745 ◽  
Author(s):  
D Mangoura ◽  
Y Sun ◽  
C Li ◽  
D Singh ◽  
D H Gutmann ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Molecular Switch ◽  
Neural Cells ◽  
Receptor Signaling

Emergence of salivary gland cell lineage diversity suggests a role for androgen-independent epidermal growth factor receptor signaling

1995 ◽  
Vol 108 (6) ◽  
pp. 2205-2212
Author(s):  
E.M. Durban ◽  
P.G. Nagpala ◽  
P.D. Barreto ◽  
E. Durban
Keyword(s):  
Salivary Gland ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egf Receptor ◽  
Cell Lineage ◽  
Mrna Levels ◽  
Receptor Signaling ◽  
Receptor Mrna ◽  
Epidermal Growth ◽  
Lineage Diversity

Diversity of cell lineages within glandular organs is generated postnatally by differentiation of committed progenitor cells. Fundamental regulatory aspects of this process are not understood. The mouse submandibular salivary gland (SSG) served as model to assess the role of epidermal growth factor (EGF) receptor signaling during emergence of cell lineage diversity. Temporal fluctuations in EGF receptor mRNA levels coincident with crucial differentiative cell lineage transitions were revealed by RNase protection analyses. Between days 2 and 5, when proacinar cells are maturing and striated duct cells emerge, EGF receptor mRNA levels were highest and all differentiating cells exhibited EGF receptor immunoreactivity. EGF receptor mRNA levels then declined sharply and immunoreactivity became confined to ductal cells. At day 11 in male mice, and days 11 and 16 in females, a second increase in EGF receptor mRNA was detected coincident with emergence of granular convoluted tubule (GCT) cells. With completion of androgen-dependent GCT cell differentiation at the onset of puberty, EGF receptor mRNA levels and intensity of immunoreactivity decreased. Androgen effects on EGF receptor mRNA or immunoreactivity could not be detected. These temporally distinct patterns of EGF receptor expression suggest that this signaling pathway is a mechanism of potential importance in emergence of cell lineage diversity in a glandular organ.

scholarly journals CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms

2019 ◽  
Vol 10 ◽  
Author(s):  
G. Karina Parra-Mercado ◽  
Alma M. Fuentes-Gonzalez ◽  
Judith Hernandez-Aranda ◽  
Monica Diaz-Coranguez ◽  
Frank M. Dautzenberg ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Pi3 Kinase ◽  
Receptor Signaling ◽  
Akt Kinase ◽  
Crf1 Receptor

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice

2016 ◽  
Vol 32 (4) ◽  
pp. 1121-1134 ◽  
Author(s):  
Yuefei Jin ◽  
Weidong Wu ◽  
Weiguo Zhang ◽  
Yang Zhao ◽  
Yongjun Wu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Lung Inflammation ◽  
Egf Receptor ◽  
Fine Particulate Matter ◽  
Receptor Signaling ◽  
Fine Particulate
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