Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice

2016 ◽  
Vol 32 (4) ◽  
pp. 1121-1134 ◽  
Author(s):  
Yuefei Jin ◽  
Weidong Wu ◽  
Weiguo Zhang ◽  
Yang Zhao ◽  
Yongjun Wu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Lung Inflammation ◽  
Egf Receptor ◽  
Fine Particulate Matter ◽  
Receptor Signaling ◽  
Fine Particulate

scholarly journals Fine particulate matter-induced lung inflammation is mediated by pyroptosis in mice

2021 ◽  
Vol 219 ◽  
pp. 112351
Author(s):  
Juan Li ◽  
Zhen An ◽  
Jie Song ◽  
Jinge Du ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Lung Inflammation ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5)

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Mengmeng Xu ◽  
Yanbei Zhang ◽  
Muyun Wang ◽  
Hai Zhang ◽  
Yuqing Chen ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Airway Hyperresponsiveness ◽  
Lung Inflammation ◽  
Transient Receptor Potential ◽  
Fine Particulate Matter ◽  
Receptor Potential ◽  
Inflammatory Infiltration ◽  
Caspase 1 ◽  
Trpv1 Channels ◽  
Fine Particulate

Exposure to fine particulate matter (PM2.5) has been associated with lung inflammation and airway hyperresponsiveness (AHR). Transient receptor potential (TRP) vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) both may play important roles in lung inflammation and AHR. We investigated whether PM2.5-induced lung inflammation and AHR could be prevented by blocking TRPV1 and TRPA1 channels. Mice were injected intraperitoneally with AMG9810 (30 mg/kg, a TRPV1 antagonist) or A967079 (30 mg/kg, a TRPA1 antagonist) or their combination or vehicle (PBS) one hour before intranasal instillation of PM2.5 (7.8 mg/kg) or vehicle (PBS) for two consecutive days, and then the mice were studied 24 h later. All pretreatments inhibited PM2.5-induced AHR and inflammatory infiltration in the lung tissue and decreased inflammatory cytokine levels in the bronchoalveolar lavage fluid, together with oxidant levels in the lung. AMG9810 inhibited MFF expression and increased MFN2 expression while A967079 inhibited DRP1 expression and increased OPA1 expression; combined pretreatment reduced MFF and DPR1 expression and increased MFN2 and OPA1 expression. All pretreatments inhibited the activation of the TLR4/NF-κB pathway, while A967079 alone, and combined with AMG9810 also reduced the activation of the NLRP3/caspase-1 pathway. Both TRPV1 and TRPA1 channels play an important role in PM2.5-induced lung inflammation and AHR. However, inhibition of the TRPA1 channel or combined inhibition of TRPA1 and TRPV1 channels resulted in greater inhibitory effect on PM2.5-induced lung injury through regulating the mitochondrial fission/fusion proteins and inhibiting the TLR4/NF-κB and NLRP3/caspase-1 pathways.

The Mortality Impact of Fine Particulate Matter in China

2020 ◽  
Author(s):  
Yazhen Gong ◽  
Shanjun Li ◽  
Nicholas Sanders ◽  
Guang Shi
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate

Size-fractionated Electrochemical Quantification for Compact Monitoring of Fine Particulate Matter

2021 ◽  
pp. 106386
Author(s):  
Heyu Yin ◽  
Sina Parsnejad ◽  
Ehsan Ashoori ◽  
Hao Wan ◽  
Wen Li ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate

SIZE SEGREGATED CHARACTERIZATION OF FINE PARTICULATE MATTER IN LEIPZIG AND MELPITZ AEROSOL

2001 ◽  
Vol 32 ◽  
pp. 353-354
Author(s):  
E. BRÜGGEMANN ◽  
T. GNAUK ◽  
K. MULLER ◽  
H. HERRMANN
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate
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