A Novel Signaling Perturbation and Ribozyme Gene Therapy Procedure to Block Rho-Kinase (ROK) Activation and Breast Tumor Metastasis

2000 ◽  
Author(s):  
Lilly Y. Bourguignon
Keyword(s):  
Gene Therapy ◽  
Breast Tumor ◽  
Tumor Metastasis ◽  
Rho Kinase

ROS-responsive nanomedicine: Towards targeting the breast tumor microenvironment

2020 ◽  
Vol 28 ◽  
Author(s):  
RamaRao Malla ◽  
Mohammad Amjad Kamal
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Therapy ◽  
Drug Resistance ◽  
Molecular Imaging ◽  
Tumor Microenvironment ◽  
Immune Cells ◽  
Breast Tumor ◽  
Imaging Techniques ◽  
Oxygen Species ◽  
Massive Accumulation

: The breast tumor microenvironment (TME) promotes drug resistance through an elaborated interaction of TME components mediated by reactive oxygen species (ROS). Despite a massive accumulation of data concerning the targeting the ROS, but little is known about the ROS-responsive nanomedicine for targeting breast TME. This review submits the ROS landscape in breast TME, including ROS biology, ROS mediated carcinogenesis, reprogramming of stromal and immune cells of TME. We also discussed ROS-based precision strategies for imaging TME, including molecular imaging techniques with advanced probes, multiplexed methods, and multi-omic profiling strategies. ROS-responsive nanomedicine also describes various therapies, such as chemo-dynamic, photodynamic, photothermal, sono-dynamic, immune, and gene therapy for BC. We expound ROS-responsive primary delivery systems for chemotherapeutics, phytochemicals, and immunotherapeutics. This review also presents recent updates on nano-theranostics for simultaneous diagnosis and treatment of BCs. We assume that review on this advancing field will be beneficial to the development of ROS-based nanotheranostics for BC.

20. ß2-Adrenergic agonist treatment inhibits 4T1 breast tumor metastasis to the lung

2014 ◽  
Vol 40 ◽  
pp. e6
Author(s):  
K.S. Madden ◽  
R.P. Dawes ◽  
D.K. Byun ◽  
E.B. Brown
Keyword(s):  
Breast Tumor ◽  
Tumor Metastasis ◽  
Adrenergic Agonist

Gene therapy of tumor metastasis by non-viral vector

2008 ◽  
Vol 32 (3) ◽  
pp. S31-S31
Author(s):  
Zheng Li ◽  
Juan Juan Xiang ◽  
Zhi Guo He ◽  
Xiao Ling Li ◽  
Xia Yu Li ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Tumor Metastasis ◽  
Viral Vector

Genomic Alterations Associated with Early Stages of Breast Tumor Metastasis

2008 ◽  
Vol 15 (7) ◽  
pp. 1989-1995 ◽  
Author(s):  
Rachel E. Ellsworth ◽  
Darrell L. Ellsworth ◽  
Heather L. Patney ◽  
Brenda Deyarmin ◽  
Jeffrey A. Hooke ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Tumor Metastasis ◽  
Genomic Alterations ◽  
Early Stages
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