scholarly journals siRNA-loaded poly(histidine-arginine)6-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis

2017 ◽  
Vol Volume 12 ◽  
pp. 3221-3234 ◽  
Author(s):  
Ping Sun ◽  
Wei Huang ◽  
Lin Kang ◽  
Mingji Jin ◽  
Bo Fan ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Tumor Metastasis ◽  
Endosomal Escape ◽  
Modified Chitosan ◽  
Chitosan Nanoparticle ◽  
Cell Penetrating

scholarly journals Breaking in and busting out: cell-penetrating peptides and the endosomal escape problem

2017 ◽  
Vol 8 (3-4) ◽  
pp. 131-141 ◽  
Author(s):  
Julia C. LeCher ◽  
Scott J. Nowak ◽  
Jonathan L. McMurry
Keyword(s):  
Cell Penetrating Peptides ◽  
Endosomal Escape ◽  
Great Promise ◽  
Delivery Methods ◽  
Oligomeric Proteins ◽  
Cell Penetrating ◽  
History Of ◽  
A Cell ◽  
Escape Problem ◽  
Primary Focus

AbstractCell-penetrating peptides (CPPs) have long held great promise for the manipulation of living cells for therapeutic and research purposes. They allow a wide array of biomolecules from large, oligomeric proteins to nucleic acids and small molecules to rapidly and efficiently traverse cytoplasmic membranes. With few exceptions, if a molecule can be associated with a CPP, it can be delivered into a cell. However, a growing realization in the field is that CPP-cargo fusions largely remain trapped in endosomes and are eventually targeted for degradation or recycling rather than released into the cytoplasm or trafficked to a desired subcellular destination. This ‘endosomal escape problem’ has confounded efforts to develop CPP-based delivery methods for drugs, enzymes, plasmids, etc. This review provides a brief history of CPP research and discusses current issues in the field with a primary focus on the endosomal escape problem, for which several promising potential solutions have been developed. Are we on the verge of developing technologies to deliver therapeutics such as siRNA, CRISPR/Cas complexes and others that are currently failing because of an inability to get into cells, or are we just chasing after another promising but unworkable technology? We make the case for optimism.

20. ß2-Adrenergic agonist treatment inhibits 4T1 breast tumor metastasis to the lung

2014 ◽  
Vol 40 ◽  
pp. e6
Author(s):  
K.S. Madden ◽  
R.P. Dawes ◽  
D.K. Byun ◽  
E.B. Brown
Keyword(s):  
Breast Tumor ◽  
Tumor Metastasis ◽  
Adrenergic Agonist

Decoding the Entry of Two Novel Cell-Penetrating Peptides in HeLa Cells:  Lipid Raft-Mediated Endocytosis and Endosomal Escape†

Biochemistry ◽  
2005 ◽  
Vol 44 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Christina Foerg ◽  
Urs Ziegler ◽  
Jimena Fernandez-Carneado ◽  
Ernest Giralt ◽  
Robert Rennert ◽  
...  
Keyword(s):  
Lipid Raft ◽  
Hela Cells ◽  
Cell Penetrating Peptides ◽  
Endosomal Escape ◽  
Cell Penetrating

Cell-penetrating peptide TAT modified chitosan for siRNA delivery

2013 ◽  
Vol 172 (1) ◽  
pp. e100-e101 ◽  
Author(s):  
Feifei Yang ◽  
Yunfei Li ◽  
Wei Huang ◽  
Wei Chen ◽  
Mingji Jin ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Cell Penetrating Peptide ◽  
Modified Chitosan ◽  
Cell Penetrating
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