Next Generation Ceramic Sand Screens as Open Hole Completion Solution in High Rate Erosive and Corrosive Well Environment at Dvalin HPHT Field, Offshore Norway

2020 ◽  
Author(s):  
Robert Ritschel ◽  
Jens Storhaug ◽  
Bjorn Olav Dahle ◽  
Frank Meschke ◽  
Peter Barth ◽  
...  
Keyword(s):  
High Rate ◽  
Next Generation ◽  
Open Hole

scholarly journals INNV-17. NEXT GENERATION SEQUENCING IMPACTS OUTCOMES IN RECURRENT PRIMARY GLIOBLASTOMA: A SINGLE-CENTER RETROSPECTIVE ANALYSIS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii120-ii120
Author(s):  
Daniel Zeitouni ◽  
Michael Catalino ◽  
Jordan Wise ◽  
Kathryn Pietrosimone ◽  
Sean McCabe ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Cox Model ◽  
Objective Response ◽  
Complete Response ◽  
High Rate ◽  
Next Generation ◽  
Disease Response ◽  
Primary Glioblastoma ◽  
Generation Sequencing ◽  
Recurrent Gbm

Abstract BACKGROUND GBM is driven by various genomic alterations. Next generation sequencing (NGS) may reveal targetable alterations. The goal of this study was to describe how NGS can inform targeted therapy (TT) selection. METHODS The medical records of patients (pts) with GBM from 2017–2019 were reviewed. Pts with actionable mutations were included in the analysis. At first progression (PD1), two cohorts of pts were defined: cohort A received TT, while cohort B received physician’s choice chemotherapy (PCC). Regression analyses were used to determine OS and PFS between cohorts. A stratified cox model was utilized to assess the effect of TT, where KPS level (low vs high) was utilized as a stratification factor. A heat map was generated describing the landscape of mutations. Disease response in cohort A was graded per RANO criteria. RESULTS There were 38 GBM pts with actionable alterations. Cohort A had 15 (39%) pts and cohort B had 23 (61%) pts. Of the 26 common alterations, 11 (42%) were deemed actionable. Pts with higher KPS were more likely to receive TT. Pts with a KPS ≥ 70 had a longer PFS while on TT. Although not well powered, pts in cohort A had a longer median OS relative to cohort B (HR 0.37 CI 0.10–1.38). The objective response rate (ORR) was 93%, with afatinib and cabozantinib resulting in complete response, one pt had progressive disease while on TT. CONCLUSION NGS for recurrent GBM yields a high rate of actionable alterations. Pts that go on TT are often younger and with higher KPS. This likely plays into their improved survival; however, it is notable that the high ORR reflects the value of NGS in deciding on TT to match alterations that are likely to respond. In conclusion, patient selection and availability of NGS impacts outcomes in recurrent GBM.

Built-in electrical field enhanced ionic transport kinetics in T−Nb2O5@MoO2 heterostructure

2021 ◽  
Author(s):  
Huihuang Huang ◽  
Guangyu Zhao ◽  
Xin Sun ◽  
Xianbo Yu ◽  
Chao Liu ◽  
...  
Keyword(s):  
Ionic Transport ◽  
Rechargeable Batteries ◽  
Transport Kinetics ◽  
High Rate ◽  
Rate Performance ◽  
Next Generation ◽  
Electrical Field ◽  
Further Development ◽  
High Rate Performance

Mg2+/Li+ hybrid ion battery (MLIB) is regarded as an engaging candidate of next generation rechargeable batteries. However, realizing superior high-rate performance is still an unremitting challenge for further development of...

scholarly journals Clinical Application of Next Generation Sequencing in Recurrent Glioblastoma

2021 ◽  
Author(s):  
Daniel Zeitouni ◽  
Michael Catalino ◽  
Jordan Wise ◽  
Sean McCabe ◽  
Kathryn Pietrosimone ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Disease Control ◽  
Objective Response ◽  
Recurrent Glioblastoma ◽  
High Rate ◽  
Next Generation ◽  
Genomic Alterations ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Recurrent Gbm

BACKGROUND: Glioblastoma (GBM) is driven by various genomic alterations. Next generation sequencing (NGS) could yield targetable alterations that may impact outcomes. The goal of this study was to describe how NGS can inform targeted therapy (TT) in this patient population. METHODS: The medical records of patients (pts) with a diagnosis of GBM from 2017-2019 were reviewed. Records of patients with recurrent GBM and genomic alterations were evaluated. Objective response rates and disease control rates were deter-mined. RESULTS: A total of 87 pts with GBM underwent NGS. Forty percent (n = 35) were considered to have actionable alterations. Of the 35, 40% (n=14) pts had their treatment changed due to an alteration. The objective response rate (ORR) of this population was 43%. The disease control rate (DCR) was 100%. The absolute mean decrease in contrast enhancing disease was 50.7% (95% CI 34.8 – 66.6). CONCLUSION: NGS for GBM, particularly in the recurrent setting, yields a high rate of actionable alterations. We observed a high ORR and DCR, reflecting the value of NGS in deciding on TT to match alterations that are likely to respond. In conclusion, patient selection and availability of NGS may impact outcomes in select pts with recurrent GBM.

Next Generation High-Rate Telemetry

2018 ◽  
Vol 36 (2) ◽  
pp. 327-337 ◽  
Author(s):  
Alessandro Ugolini ◽  
Guido Montorsi ◽  
Giulio Colavolpe
Keyword(s):  
High Rate ◽  
Next Generation

Unique 15kpsi Multistage Fracturing Liner System Delivers Solution to Overcome Tight Formation Challenges

2021 ◽  
Author(s):  
Beau R Wright ◽  
Parvez Khan
Keyword(s):  
High Pressure ◽  
High Rate ◽  
Axial Loads ◽  
Wellbore Instability ◽  
Liner System ◽  
Open Hole ◽  
Important Challenge ◽  
Bottom Hole Assembly ◽  
And Function ◽  
Tight Formation

Abstract Open hole Multistage Fracturing (MSF) systems have been deployed for treating open hole formations with multiple, high rate hydraulic fracturing stages while gaining efficiency during pumping operations unlike traditional plug-and-perf operations. One important challenge within the industry was availability of an open hole packer system that can overcome tough wellbore conditions during deployment and function as designed during the high rate high pressure stimulation operations. This paper will discuss the successful planning and deployment of one such system. For successful deployment of any open hole fracturing completion, one must first consider the environment that the system will be deployed into. Lateral length, open hole size, parent casing size and tubing stresses during fracturing and production all inclusively influence the need for a robust and reliable system. Other several important considerations to be deployed as a liner is the compatibility of the completion tools with the Liner deployment system, the robustness of being deployed into challenging open hole conditions where capability of high circulating rates and rotation become mandatory to get the bottom hole assembly (BHA) to its final setting depth. Last but not least, in order to achieve successful stimulation, each component of the system after overcoming all the deployment obstacles should function as designed withstanding treating differentials as high as 15kpsi, while simultaneously accommodating induced axial loads caused by these high-pressure treatments. The development and testing of individual components of the system was done keeping in mind wellbore instability and obstacles the completion will have to overcome during deployment. The field execution was planned with close collaboration with the operator and other key services that were involved for drilling the well. Real-time monitoring of the well allowed for simultaneous swift implementation of changes required on tool activation pressures, identification of hazards and mitigation plan to overcome challenges in order to execute the job successfully. It is worth mentioning that the successful deployment of this system represents the first use of additive manufacturing in high pressure, hydraulic set open hole packers. This technology allowed overcoming the barriers of challenges associated with deploying open hole completion in tight challenging formations that would otherwise have limited deployment capabilities.

15K Multistage Fracturing Completion System Addresses Operational Challenges, Improves Production Performance and Cost Savings in Openhole Environments

2021 ◽  
Author(s):  
Rasim Serdar Rodoplu ◽  
Adegbenga O. Sobowale ◽  
Jon E. Hanson ◽  
Beau R. Wright
Keyword(s):  
New Technology ◽  
Cost Savings ◽  
Cost Effective ◽  
Production Performance ◽  
High Rate ◽  
Field Development ◽  
Additional Equipment ◽  
Effective Manner ◽  
Open Hole ◽  
The Right

Abstract Multistage fracturing (MSF) ball drop completion systems have been utilized around the globe for effectively treating formations completed as open hole and cemented. Multiple, high-rate hydraulic fracturing stages are pumped through these completions while gaining efficiency during pumping operations. A challenge within the industry was developing systems that are capable of higher pressures (greater than 10k psi) while still being able to be deployed in challenging openhole environments with minimum equipment and intervention requirements. This paper will discuss the planning, deployment and fracturing execution operations of an improved version of one of these systems. To be able to effectively utilize any MSF completion system; formation properties, deployment environment, lateral length, openhole size, liner size, and tubing movements during fracturing should be thoroughly analyzed and equally considered. To create a reliable system, another important consideration is how the system will be deployed; a long string to surface, or will it be deployed as part of a liner hanger system? In the case of the latter, it should be compatible with the liner hanger system by accommodating multiple balls to set and release the hanger system and actuate the openhole packers. In tight formation environments, where treating pressure differentials reaches as high as 15,000 psi during fracturing operations, openhole packers that are capable of holding these pressures in challenging openhole conditions are needed. Not only the packers but also the remaining completion system components need to be capable of withstanding, including burst, collapse, and ball-to-ball seat differential while simultaneously accommodating the pressure with cooling and ballooning induced tubing movement caused by these high pressure treatments. Improving such a robust design with innovative solutions, such as dissolvable frac balls that can handle 15,000 psi differential, optimizes the overall process. The completion design, deployment, and subsequent fracturing operations on a well showcases how effective consideration of components operates as a system can create a reliable MSF system. It also demonstrates how close collaboration between reservoir management, production engineering, completion experts, and vendor results in a coordination of efforts that eliminates operational hazards, thus ensuring smooth operations. The successful deployment of an openhole MSF completion system that can handle 15,000 psi with dissolving frac balls and eliminating openhole anchors helped pave the way to deal with tighter formations in an efficient and cost-effective manner. With the help of this new technology, the well planners were able to address operational challenges that would have otherwise required additional equipment or would have limited deployment capabilities. The engineering approach and design to develop this completion system and utilization in the right candidate confirmed the benefit of the novel completion for field development options.

A bottom-up synthetic hierarchical buffer structure of copper silicon nanowire hybrids as ultra-stable and high-rate lithium-ion battery anodes

2018 ◽  
Vol 6 (17) ◽  
pp. 7877-7886 ◽  
Author(s):  
Hucheng Song ◽  
Sheng Wang ◽  
Xiaoying Song ◽  
Huafeng Yang ◽  
Gaohui Du ◽  
...  
Keyword(s):  
Lithium Ion Batteries ◽  
Lithium Ion Battery ◽  
Anode Material ◽  
Silicon Nanowire ◽  
Lithium Ion ◽  
High Energy ◽  
High Rate ◽  
Next Generation ◽  
Bottom Up ◽  
Buffer Structure

Silicon (Si) is a promising anode material for next-generation high-energy lithium-ion batteries (LIBs).

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