Next Generation High-Rate Telemetry

2018 ◽  
Vol 36 (2) ◽  
pp. 327-337 ◽  
Author(s):  
Alessandro Ugolini ◽  
Guido Montorsi ◽  
Giulio Colavolpe
Keyword(s):  
High Rate ◽  
Next Generation

scholarly journals INNV-17. NEXT GENERATION SEQUENCING IMPACTS OUTCOMES IN RECURRENT PRIMARY GLIOBLASTOMA: A SINGLE-CENTER RETROSPECTIVE ANALYSIS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii120-ii120
Author(s):  
Daniel Zeitouni ◽  
Michael Catalino ◽  
Jordan Wise ◽  
Kathryn Pietrosimone ◽  
Sean McCabe ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Cox Model ◽  
Objective Response ◽  
Complete Response ◽  
High Rate ◽  
Next Generation ◽  
Disease Response ◽  
Primary Glioblastoma ◽  
Generation Sequencing ◽  
Recurrent Gbm

Abstract BACKGROUND GBM is driven by various genomic alterations. Next generation sequencing (NGS) may reveal targetable alterations. The goal of this study was to describe how NGS can inform targeted therapy (TT) selection. METHODS The medical records of patients (pts) with GBM from 2017–2019 were reviewed. Pts with actionable mutations were included in the analysis. At first progression (PD1), two cohorts of pts were defined: cohort A received TT, while cohort B received physician’s choice chemotherapy (PCC). Regression analyses were used to determine OS and PFS between cohorts. A stratified cox model was utilized to assess the effect of TT, where KPS level (low vs high) was utilized as a stratification factor. A heat map was generated describing the landscape of mutations. Disease response in cohort A was graded per RANO criteria. RESULTS There were 38 GBM pts with actionable alterations. Cohort A had 15 (39%) pts and cohort B had 23 (61%) pts. Of the 26 common alterations, 11 (42%) were deemed actionable. Pts with higher KPS were more likely to receive TT. Pts with a KPS ≥ 70 had a longer PFS while on TT. Although not well powered, pts in cohort A had a longer median OS relative to cohort B (HR 0.37 CI 0.10–1.38). The objective response rate (ORR) was 93%, with afatinib and cabozantinib resulting in complete response, one pt had progressive disease while on TT. CONCLUSION NGS for recurrent GBM yields a high rate of actionable alterations. Pts that go on TT are often younger and with higher KPS. This likely plays into their improved survival; however, it is notable that the high ORR reflects the value of NGS in deciding on TT to match alterations that are likely to respond. In conclusion, patient selection and availability of NGS impacts outcomes in recurrent GBM.

Built-in electrical field enhanced ionic transport kinetics in T−Nb2O5@MoO2 heterostructure

2021 ◽  
Author(s):  
Huihuang Huang ◽  
Guangyu Zhao ◽  
Xin Sun ◽  
Xianbo Yu ◽  
Chao Liu ◽  
...  
Keyword(s):  
Ionic Transport ◽  
Rechargeable Batteries ◽  
Transport Kinetics ◽  
High Rate ◽  
Rate Performance ◽  
Next Generation ◽  
Electrical Field ◽  
Further Development ◽  
High Rate Performance

Mg2+/Li+ hybrid ion battery (MLIB) is regarded as an engaging candidate of next generation rechargeable batteries. However, realizing superior high-rate performance is still an unremitting challenge for further development of...

scholarly journals Clinical Application of Next Generation Sequencing in Recurrent Glioblastoma

2021 ◽  
Author(s):  
Daniel Zeitouni ◽  
Michael Catalino ◽  
Jordan Wise ◽  
Sean McCabe ◽  
Kathryn Pietrosimone ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Disease Control ◽  
Objective Response ◽  
Recurrent Glioblastoma ◽  
High Rate ◽  
Next Generation ◽  
Genomic Alterations ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Recurrent Gbm

BACKGROUND: Glioblastoma (GBM) is driven by various genomic alterations. Next generation sequencing (NGS) could yield targetable alterations that may impact outcomes. The goal of this study was to describe how NGS can inform targeted therapy (TT) in this patient population. METHODS: The medical records of patients (pts) with a diagnosis of GBM from 2017-2019 were reviewed. Records of patients with recurrent GBM and genomic alterations were evaluated. Objective response rates and disease control rates were deter-mined. RESULTS: A total of 87 pts with GBM underwent NGS. Forty percent (n = 35) were considered to have actionable alterations. Of the 35, 40% (n=14) pts had their treatment changed due to an alteration. The objective response rate (ORR) of this population was 43%. The disease control rate (DCR) was 100%. The absolute mean decrease in contrast enhancing disease was 50.7% (95% CI 34.8 – 66.6). CONCLUSION: NGS for GBM, particularly in the recurrent setting, yields a high rate of actionable alterations. We observed a high ORR and DCR, reflecting the value of NGS in deciding on TT to match alterations that are likely to respond. In conclusion, patient selection and availability of NGS may impact outcomes in select pts with recurrent GBM.

Next Generation Ceramic Sand Screens as Open Hole Completion Solution in High Rate Erosive and Corrosive Well Environment at Dvalin HPHT Field, Offshore Norway

2020 ◽  
Author(s):  
Robert Ritschel ◽  
Jens Storhaug ◽  
Bjorn Olav Dahle ◽  
Frank Meschke ◽  
Peter Barth ◽  
...  
Keyword(s):  
High Rate ◽  
Next Generation ◽  
Open Hole

A bottom-up synthetic hierarchical buffer structure of copper silicon nanowire hybrids as ultra-stable and high-rate lithium-ion battery anodes

2018 ◽  
Vol 6 (17) ◽  
pp. 7877-7886 ◽  
Author(s):  
Hucheng Song ◽  
Sheng Wang ◽  
Xiaoying Song ◽  
Huafeng Yang ◽  
Gaohui Du ◽  
...  
Keyword(s):  
Lithium Ion Batteries ◽  
Lithium Ion Battery ◽  
Anode Material ◽  
Silicon Nanowire ◽  
Lithium Ion ◽  
High Energy ◽  
High Rate ◽  
Next Generation ◽  
Bottom Up ◽  
Buffer Structure

Silicon (Si) is a promising anode material for next-generation high-energy lithium-ion batteries (LIBs).

scholarly journals Preimplantation Genetic Testing of Aneuploidy by Next Generation Sequencing: Association of Maternal Age and Chromosomal Abnormalities of Blastocyst

2019 ◽  
Vol 7 (24) ◽  
pp. 4427-4431 ◽  
Author(s):  
Tien-Truong Dang ◽  
Thi Mui Phung ◽  
Hoang Le ◽  
Thi-Bich-Van Nguyen ◽  
Thi Sim Nguyen ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Next Generation Sequencing ◽  
Maternal Age ◽  
Chromosomal Abnormalities ◽  
Abnormal Chromosome ◽  
High Rate ◽  
Next Generation ◽  
Chromosome 11 ◽  
Preimplantation Genetic Testing ◽  
Generation Sequencing

BACKGROUND: Aneuploidy is a major cause of miscarriages and implantation failure. Preimplantation genetic testing for aneuploidy (PGT-A) by Next Generation Sequencing (NGS) is able to detect of the numeral and structural chromosomal abnormalities of embryos in vitro fertilization (IVF). AIM: This study was aimed to assess the relationship between maternal age and chromosomal abnormalities NGS technology. METHODS: 603 human trophectoderm (TE) biopsied samples were tested by Veriseq kit of Illumina. The relation of marternal age and chromosomal abnormality of blastocyst embryo was evaluated. RESULTS: Among the 603 TE samples, 247 samples (42.73%) presented as chromosomal abnormalities. The abnormalities occurred to almost chromosomes, and the most popular aneuploidy observed is 22. Aneuploidy rate from 0.87% in chromosome 11 to 6.06% in chromosome 22. The rate of abnormal chromosome increased dramatically in group of mother's ages over 37 (54.17%) comparing to group of mother's ages less than 37 (38.05%) (p < 0.000). The Abnormal chromosome and maternal age has a positive correlation with r = 0.4783 (p<0.0001). CONCLUSION: These results showed high rate abnormal chromosome and correlated with advanced maternal age of blastocyst embryos.

Exploring the next generation socialisation to entrepreneurship in family businesses: insights from the Moroccan community

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Widad Ibouder ◽  
Alain Jean-Claude Fayolle ◽  
Abdenbi Louitri
Keyword(s):  
Single Case ◽  
Study Data ◽  
Family Businesses ◽  
High Rate ◽  
Next Generation ◽  
Content Type ◽  
Entrepreneurial Spirit ◽  
Exploratory Approach ◽  
Set Up ◽  
Rate Of Failure

Purpose In Morocco, due to the high rate of failure in generational transfers, many family businesses are threatened with disappearance. This paper aims to focus on entrepreneurship and seeks to understand how the family business maintains its entrepreneurial orientation through the family’s entrepreneurial socialisation of the next generation, which aims to prepare them for the role of family entrepreneur. The study aims both to describe the socialisation process and to understand the context necessary to place the young community in an entrepreneurial dynamic. Design/methodology/approach Using an exploratory approach, this paper favours the single case study; data were collected from five participants from both generations, then this study matches the interviews from the founding generation with those from the next generation; in addition to a triad at the employee level. Findings The analysis shows that the early participation alongside the founding generation in entrepreneurial processes, initiates a sense of entrepreneurship in the next generation and the confidence gradually builds up through the achievements of the latter; which, in turn, increases the possibility to set up innovative projects by giving the necessary autonomy to carry them out. Practical implications The document underlines the importance of establishing a culture of transmission to promote entrepreneurship amongst the young community to engage it in exploring and seeking new opportunities for development and innovation. Originality/value Studying the transmission of the entrepreneurial spirit through the prism of socialisation provides an understanding of the context necessary to place the next generation in an entrepreneurial dynamic.

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