scholarly journals cmstatr: An R Package for Statistical Analysis of Composite Material Data

2020 ◽  
Vol 5 (51) ◽  
pp. 2265
Author(s):  
Stefan Kloppenborg
Keyword(s):  
Composite Material ◽  
Statistical Analysis ◽  
R Package ◽  
Material Data

scholarly journals AlpsNMR: an R package for signal processing of fully untargeted NMR-based metabolomics

2020 ◽  
Vol 36 (9) ◽  
pp. 2943-2945 ◽  
Author(s):  
Francisco Madrid-Gambin ◽  
Sergio Oller-Moreno ◽  
Luis Fernandez ◽  
Simona Bartova ◽  
Maria Pilar Giner ◽  
...  
Keyword(s):  
Signal Processing ◽  
Statistical Analysis ◽  
Processing System ◽  
R Package ◽  
Supplementary Information ◽  
Test Case ◽  
Previous Knowledge ◽  
Spectral Processing ◽  
Computational Tools ◽  
User Friendly

Abstract Summary Nuclear magnetic resonance (NMR)-based metabolomics is widely used to obtain metabolic fingerprints of biological systems. While targeted workflows require previous knowledge of metabolites, prior to statistical analysis, untargeted approaches remain a challenge. Computational tools dealing with fully untargeted NMR-based metabolomics are still scarce or not user-friendly. Therefore, we developed AlpsNMR (Automated spectraL Processing System for NMR), an R package that provides automated and efficient signal processing for untargeted NMR metabolomics. AlpsNMR includes spectra loading, metadata handling, automated outlier detection, spectra alignment and peak-picking, integration and normalization. The resulting output can be used for further statistical analysis. AlpsNMR proved effective in detecting metabolite changes in a test case. The tool allows less experienced users to easily implement this workflow from spectra to a ready-to-use dataset in their routines. Availability and implementation The AlpsNMR R package and tutorial is freely available to download from http://github.com/sipss/AlpsNMR under the MIT license. Supplementary information Supplementary data are available at Bioinformatics online.

An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay

2020 ◽  
Author(s):  
Marne C Hagemeijer ◽  
Annelotte M Vonk ◽  
Nikhil T Awatade ◽  
Iris A L Silva ◽  
Christian Tischer ◽  
...  
Keyword(s):  
Content Analysis ◽  
Statistical Analysis ◽  
Open Source ◽  
R Package ◽  
Supplementary Information ◽  
Image Quantification ◽  
Quantification Method ◽  
Analysis Workflow ◽  
High Content Analysis ◽  
Microscopy Images

Abstract Motivation The forskolin-induced swelling (FIS) assay has become the preferential assay to predict the efficacy of approved and investigational CFTR-modulating drugs for individuals with cystic fibrosis (CF). Currently, no standardized quantification method of FIS data exists thereby hampering inter-laboratory reproducibility. Results We developed a complete open-source workflow for standardized high-content analysis of CFTR function measurements in intestinal organoids using raw microscopy images as input. The workflow includes tools for (i) file and metadata handling; (ii) image quantification and (iii) statistical analysis. Our workflow reproduced results generated by published proprietary analysis protocols and enables standardized CFTR function measurements in CF organoids. Availability All workflow components are open-source and freely available: the htmrenamer R package for file handling https://github.com/hmbotelho/htmrenamer; CellProfiler and ImageJ analysis scripts/pipelines https://github.com/hmbotelho/FIS_image_analysis; the Organoid Analyst application for statistical analysis https://github.com/hmbotelho/organoid_analyst; detailed usage instructions and a demonstration dataset https://github.com/hmbotelho/FIS_analysis. Distributed under GPL v3.0. Supplementary information Supplementary information and a stepwise guide for software installation and data analysis for training purposes are available at Bioinformatics online.

scholarly journals MiDAS—Meaningful Immunogenetic Data at Scale

2021 ◽  
Vol 17 (7) ◽  
pp. e1009131
Author(s):  
Maciej Migdal ◽  
Dan Fu Ruan ◽  
William F. Forrest ◽  
Amir Horowitz ◽  
Christian Hammer
Keyword(s):  
Statistical Analysis ◽  
Input Data ◽  
Association Studies ◽  
Allelic Diversity ◽  
R Package ◽  
Evolutionary Divergence ◽  
Statistical Association ◽  
Measurement Scales ◽  
Efficient Utilization ◽  
Disease Biology

Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. However, association studies involving immunogenetic loci most commonly involve simple analyses of classical HLA allelic diversity, resulting in limitations regarding the interpretability and reproducibility of results. We here present MiDAS, a comprehensive R package for immunogenetic data transformation and statistical analysis. MiDAS recodes input data in the form of HLA alleles and KIR types into biologically meaningful variables, allowing HLA amino acid fine mapping, analyses of HLA evolutionary divergence as well as experimentally validated HLA-KIR interactions. Further, MiDAS enables comprehensive statistical association analysis workflows with phenotypes of diverse measurement scales. MiDAS thus closes the gap between the inference of immunogenetic variation and its efficient utilization to make relevant discoveries related to immune and disease biology. It is freely available under a MIT license.

scholarly journals drawProteins: a Bioconductor/R package for reproducible and programmatic generation of protein schematics

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1105 ◽  
Author(s):  
Paul Brennan
Keyword(s):  
Statistical Analysis ◽  
R Package ◽  
Data Frame ◽  
P Protein ◽  
Uniprot Database ◽  
Uniprot Accession ◽  
Additional Protein ◽  
Knowledge Communication

Protein schematics are valuable for research, teaching and knowledge communication. However, the tools used to automate the process are challenging. The purpose of the drawProteins package is to enable the generation of schematics of proteins in an automated fashion that can integrate with the Bioconductor/R suite of tools for bioinformatics and statistical analysis. Using UniProt accession numbers, the package uses the UniProt API to get the features of the protein from the UniProt database. The features are assembled into a data frame and visualized using adaptations of the ggplot2 package. Visualizations can be customised in many ways including adding additional protein features information from other data frames, altering colors and protein names and adding extra layers using other ggplot2 functions. This can be completed within a script that makes the workflow reproducible and sharable.

scholarly journals A study on the sandwich-style notched tensile specimens for different materials through a simulation analysis

2018 ◽  
Vol 7 (3.3) ◽  
pp. 324
Author(s):  
Jung Ho Lee ◽  
Jae Ung Cho
Keyword(s):  
Tensile Strength ◽  
Stainless Steel ◽  
Composite Material ◽  
Statistical Analysis ◽  
Composite Materials ◽  
3D Modeling ◽  
Simulation Analysis ◽  
Maximum Load ◽  
Design Software ◽  
Strength And Durability

Background/Objectives: This study designed a model that used the sandwich-style notched tensile specimens of the same specifications by applying to the properties of CFRP, stainless steel, and aluminum, and performed a test simulation.Methods/Statistical analysis: The study used CATIA design software to perform the 3D modeling of the sandwich-style notched tensile specimens with the properties of CFRP, a composite material, and stainless steel and aluminum, both ordinary metals, and then, performed a tensile test simulation.Findings: By designing the sandwich-style notched tensile specimens of the same specifications and performing a test simulation, we were able to verify the tensile strength and durability of the specimens for the different materials. This study result showed that unlike the specimens for the ordinary metals, those specimens with the properties of the composite material of CFRP first showed maximum load instead of breaking immediately due to the fibers in CFRP, before they resisted displacement in response to the alternately increasing and decreasing load until it fractured. To be specific, we saw that the CFRP specimens had the more excellent tensile strength and durability.Improvements/Applications: The data obtained from the studies will serve as the basic data for studies on the composite materials like CFRP and other various materials.  

scholarly journals The skipper butterflies (Lepidoptera: Hesperiidae) of the Reserva Ecológica Leonelo Oviedo, San José, Costa Rica

2019 ◽  
Vol 67 (2SUPL) ◽  
pp. S228-S248
Author(s):  
Luis-Ricardo Murillo-Hiller ◽  
Oscar-Antonio Segura-Bermúdez ◽  
Juan-Diego Barquero ◽  
Federico Bolaños
Keyword(s):  
Cluster Analysis ◽  
Statistical Analysis ◽  
Costa Rica ◽  
Hierarchical Cluster ◽  
R Package ◽  
Minimum Variance ◽  
Shannon Index ◽  
Wet Season ◽  
Identification Guide ◽  
Different Seasons

Hesperiidae is one of the most diverse families of butterflies in Costa Rica, with approximately 486 species. Even so, there are few butterfly lists where this group has been included. In this paper, we present information on seasonality, abundance and natural history features of this family for the Leonelo Oviedo Ecological Reserve (RELO), a 2 ha forest embedded in an urban matrix. Over the course of two years, a monthly sampling was carried out on a 270 m trail across the Reserve from 08:00 to 12:00, collecting all the individuals located within 5 m on each side of the trail. To better represent the richness, individuals were also randomly collected for more than ten years, but the butterflies collected in this way were not included in the statistical analysis. Photographs were taken of all the species in order to provide an identification guide. For the cryptic species, drawings and dissections of the genitalia were made. For the community indexes we used Microsoft Excel and the Shannon index with base two logarithm. For the summary of the monthly data analysis were done according to dry and wet season. For a comparison of richness and abundance we did a g-test to evaluate if there are differences between seasons; however, with the use of the R package vegan a hierarchical cluster analysis was done using the Jaccard index with Wards minimum variance agglomerative method. With R package pvclust the uncertainty of the clusters based on a bootstrap with 10 000 iterations. 423 individuals of 49 species were included in the statistical analysis, from a total of 435 individuals of 58 species. A tendency to greater richness and abundance of skippers was found during the dry season. Through the cluster analysis, it was possible to determine that in relation to the diversity of skippers, both wet seasons are grouped significantly (P = 0.05). The dry seasons are also grouped significantly (P = 0.05). The reserve has connectivity with other green areas via a stream. During the wet season, plant growth increases connectivity, which could lead to the entry of new individuals of different species that are not permanent residents of RELO and establish small populations, increasing the richness and abundance of species. This added to the variation in the occurrence of some species of butterflies in response to seasonal variations and differences in the availability of resources in different seasons explains the grouping of species between seasons.

scholarly journals TRAPR: R Package for Statistical Analysis and Visualization of RNA-Seq Data

2017 ◽  
Vol 15 (1) ◽  
pp. 51 ◽  
Author(s):  
Jae Hyun Lim ◽  
Soo Youn Lee ◽  
Ju Han Kim
Keyword(s):  
Statistical Analysis ◽  
R Package ◽  
Rna Seq
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