Locally Delivered Bisphosphonate for Enhancement of Bone Formation and Implant Fixation

2009 ◽  
Vol 91 (Suppl 6) ◽  
pp. 23-31 ◽  
Author(s):  
J Dennis Bobyn ◽  
Kimberly McKenzie ◽  
Dorota Karabasz ◽  
Jan J Krygier ◽  
Michael Tanzer
Keyword(s):  
Bone Formation ◽  
Implant Fixation

Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

2014 ◽  
Vol 103 (4) ◽  
pp. 1357-1365 ◽  
Author(s):  
Ming Ding ◽  
Christina M. Andreasen ◽  
Mads L. Dencker ◽  
Anders E. Jensen ◽  
Naseem Theilgaard ◽  
...  
Keyword(s):  
Bone Formation ◽  
Small Cell ◽  
Cell Binding ◽  
Implant Fixation ◽  
Binding Peptide

scholarly journals Assessment of activated porous granules on implant fixation and early bone formation in sheep

2016 ◽  
Vol 5 ◽  
pp. 38-47 ◽  
Author(s):  
Ming Ding ◽  
Susan S. Henriksen ◽  
Naseem Theilgaard ◽  
Søren Overgaard
Keyword(s):  
Bone Formation ◽  
Implant Fixation ◽  
Early Bone Formation

The effect of enzymatically degradable IPN coatings on peri-implant bone formation and implant fixation

2007 ◽  
Vol 81A (3) ◽  
pp. 720-727 ◽  
Author(s):  
James E. Ho ◽  
Thomas A. Barber ◽  
Amarjit S. Virdi ◽  
Dale R. Sumner ◽  
Kevin E. Healy
Keyword(s):  
Bone Formation ◽  
Implant Fixation

scholarly journals Biological Effect of Single or Combined Pharmacological Therapy Using Alendronate and Simvastatin on Implant Osseointegration: An In Vivo Study in Healthy and Osteoporotic Rat Models

2020 ◽  
Vol 10 (12) ◽  
pp. 4298
Author(s):  
Amani M. Basudan ◽  
Marwa Y. Shaheen ◽  
Abdurahman A. Niazy ◽  
Jeroen J.J.P. van den Beucken ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Bone Formation ◽  
Biomechanical Testing ◽  
Pharmacological Therapy ◽  
Histological Evaluation ◽  
Osteoporotic Bone ◽  
Implant Fixation ◽  
Superior Effect ◽  
Female Wistar Rats ◽  
Bone To Implant Contact

To evaluate peri-implant bone formation following single or combined systemic administration of alendronate and simvastatin in healthy and osteoporotic rats, eighty female Wistar rats were ovariectomized (n = 40) or sham-operated (n = 40). At six weeks, implants were placed in femoral condyles. Then, ovariectomized (OVX) and sham-operated (SHAM) animals received daily subcutaneous alendronate (50 µg/kg), simvastatin (5 mg/kg), or both, for three weeks. Control animals received subcutaneous saline. Thereafter, specimens were retrieved for biomechanical testing, histological evaluation, and bone area (BA%) and bone-to-implant contact (BIC%). In healthy and osteoporotic rats, similar (p > 0.05) push-out values were observed for all groups. For BA% analysis, control rats showed similar results for OVX (9.2% ± 2.4%) and SHAM (11.1% ± 3.5%) animals. In contrast, single or combined drug therapy significantly increased BA% compared to controls in both healthy and osteoporotic conditions (p < 0.05). In osteoporotic conditions, alendronate alone showed a superior effect on BA% compared to simvastatin alone, or their combination. Systemic alendronate, simvastatin, or both showed a similar BIC% compared to controls (p > 0.05). The present study demonstrates that single or combined systemic alendronate and simvastatin increases bone formation around implants (i.e., distance osteogenesis) in healthy and osteoporotic bone conditions. However, these drugs showed no beneficial effect on direct bone-to-implant contact or implant fixation.

scholarly journals Periosteal Augmentation of Allograft Bone and its Effect on Implant Fixation - An Experimental Study on 12 Dogs§

2013 ◽  
Vol 7 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Jeppe Barckman ◽  
Jorgen Baas ◽  
Mette Sørensen ◽  
Joan E Bechtold ◽  
Kjeld Soballe
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Bone Repair ◽  
Fibrous Tissue ◽  
Titanium Implants ◽  
Allograft Bone ◽  
New Bone Formation ◽  
Implant Fixation ◽  
Implant Surface ◽  
Cambium Layer

Purpose: Periosteum provides essential cellular and biological components necessary for fracture healing and bone repair. We hypothesized that augmenting allograft bone by adding fragmented autologous periosteum would improve fixation of grafted implants. Methods: In each of twelve dogs, we implanted two unloaded cylindrical (10 mm x 6 mm) titanium implants into the distal femur. The implants were surrounded by a 2.5-mm gap into which morselized allograft bone with or without addition of fragmented autologous periosteum was impacted. After four weeks, the animals were euthanized and the implants were evaluated by histomorphometric analysis and mechanical push-out test. Results: Although less new bone was found on the implant surface and increased volume of fibrous tissue was present in the gap around the implant, no difference was found between treatment groups regarding the mechanical parameters. Increased new bone formation was observed in the immediate vicinity of the periosteum fragments within the bone graft. Conclusion: The method for periosteal augmentation used in this study did not alter the mechanical fixation although osseointegration was impaired. The observed activity of new bone formation at the boundary of the periosteum fragments may indicate maintained bone stimulating properties of the transplanted cambium layer. Augmenting the bone graft by smaller fragments of periosteum, isolated cambium layer tissue or cultured periosteal cells could be studied in the future.

scholarly journals Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Wei Zhou ◽  
Yu Liu ◽  
Jining Shen ◽  
Binqing Yu ◽  
Jiaxiang Bai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Formation ◽  
Bone Mass ◽  
Signaling Pathway ◽  
Implant Failure ◽  
Control Group ◽  
Protective Effects ◽  
Implant Fixation ◽  
Bone Mass Loss ◽  
Ovx Rats

Bone mass loss around prostheses is a major cause of implant failure, especially in postmenopausal osteoporosis patients. In osteoporosis, excess oxidative stress largely contributed abnormal bone remodeling. Melatonin, which is synthesized from the pineal gland, promotes osteoblast differentiation and bone formation and has effectively been used to combat oxidative stress. Thus, we determined if melatonin can inhibit oxidative stress to promote osteogenesis and improve bone mass around prostheses in osteoporosis. In this study, we observed that received melatonin at 50 mg/kg body weight significantly increased periprosthetic bone mass as well as implant fixation intensity in ovariectomized (OVX) rats. Meanwhile, it decreased the expression of oxidative stress markers (NAPDH oxidase 2 and cytochrome c) and enhanced expressing level of the formation markers of bones (alkaline phosphatase, osteocalcin, and osterix) around prostheses compared to that in the control group. Additionally, melatonin decreased hydrogen peroxide- (H2O2-) induced oxidative stress and restored the osteogenesis potential of MC3T3-E1 cells. Mechanistically, melatonin clearly increased mitochondrial sirtuin 3 (SIRT3) expression and decreased the ratio of acetylated superoxide dismutase 2 (AC-SOD2)/SOD2 compared to the H2O2 group. SIRT3 inhibition counteracted the protective effects of melatonin on oxidative stress and bone formation. Together, the results showed that melatonin ameliorated oxidative stress in mitochondrial via the SIRT3/SOD2 signaling pathway, thereby promoting osteogenesis, improving bone mass around the prostheses, and increasing initial stability. Thus, melatonin might be a suitable candidate to decrease the rate of implant failure and lengthen the lifespan of prostheses after total joint arthroplasty.

EFFECT OF ALENDRONATE-CONTAINING COATINGS ON OSTEOINTEGRATION INTO POROUS TANTALUM IN A CORTICAL BONE MODEL

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250007 ◽  
Author(s):  
KE DUAN ◽  
YOUXIN HU ◽  
KAREN LONG ◽  
ANDREW TOMS ◽  
HELEN M. BURT ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Drug Dose ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
New Bone Formation ◽  
Implant Fixation ◽  
Porous Tantalum ◽  
High Drug ◽  
Drug Coating

Hip replacement is extensively performed in hips with serious damages. The clinical outcomes of hip implants remain to be improved. Local delivery of bisphosphonates may improve implant fixation by positively affecting local bone modeling. In this study, two alendronate-containing coatings were prepared on porous tantalum by electrolytic deposition. Calcium phosphate coating was deposited and adsorbed with alendronate; the resulting coating had a low drug dose and slow release rate. Solid calcium alendronate coating was also deposited on tantalum; the resulting coating had high drug dose and faster release rate. The effects of the two coatings on new bone formation and implant fixation were studied in the rabbit tibial cortex. Four weeks after implantation, the implants with adsorbed alendronate showed the highest total new bone formation and mechanical fixation, whereas the implants with solid drug coating showed slightly lower fixation and total new bone formation than control bare implants. The improvement by the alendronate-adsorbed calcium phosphate coating provides potentials of enhancing early fixation of porous implants. The solid drug coating warranted further studies to exploit its high drug dose for inhibiting future osteolysis.

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