Biologic Augmentation of Rotator Cuff Tendon-Healing with Use of a Mixture of Osteoinductive Growth Factors*

2007 ◽  
Vol 89 (11) ◽  
pp. 2485-2497 ◽  
Author(s):  
Scott A. Rodeo ◽  
Hollis G. Potter ◽  
Sumito Kawamura ◽  
A. Simon Turner ◽  
Hyon Jeong Kim ◽  
...  
Keyword(s):  
Growth Factors ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Rotator Cuff Tendon

Biologic Augmentation of Rotator Cuff Tendon-Healing with Use of a Mixture of Osteoinductive Growth Factors*

2007 ◽  
Vol 89 (11) ◽  
pp. 2485-2497 ◽  
Author(s):  
Scott A. Rodeo ◽  
Hollis G. Potter ◽  
Sumito Kawamura ◽  
A. Simon Turner ◽  
Hyon Jeong Kim ◽  
...  
Keyword(s):  
Growth Factors ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Rotator Cuff Tendon

Tenocytes of chronic rotator cuff tendon tears can be stimulated by platelet-released growth factors

2013 ◽  
Vol 22 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Sven Hoppe ◽  
Mauro Alini ◽  
Lorin M. Benneker ◽  
Stefan Milz ◽  
Pascal Boileau ◽  
...  
Keyword(s):  
Growth Factors ◽  
Rotator Cuff ◽  
Rotator Cuff Tendon ◽  
Tendon Tears

scholarly journals Therapeutic potential of exosomes in rotator cuff tendon healing

2019 ◽  
Vol 37 (5) ◽  
pp. 759-767 ◽  
Author(s):  
Denton E. Connor ◽  
Jordan A. Paulus ◽  
Parinaz Jila Dabestani ◽  
Finosh K. Thankam ◽  
Matthew F. Dilisio ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Therapeutic Potential ◽  
Tendon Healing ◽  
Rotator Cuff Tendon

scholarly journals In vitro effects of alendronate on fibroblasts of the human rotator cuff tendon

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Chang-Meen Sung ◽  
Ra Jeong Kim ◽  
Young-Sool Hah ◽  
Ji-Yong Gwark ◽  
Hyung Bin Park
Keyword(s):  
Wound Healing ◽  
Rotator Cuff ◽  
Cell Viability ◽  
Caspase 3 ◽  
Tendon Healing ◽  
Cellular Migration ◽  
Mineral Density ◽  
Rotator Cuff Tendon ◽  
Human Rotator Cuff

Abstract Background Bone mineral density of the humeral head is an independent determining factor for postoperative rotator cuff tendon healing. Bisphosphonates, which are commonly used to treat osteoporosis, have raised concerns regarding their relationships to osteonecrosis of the jaw and to atypical fracture of the femur. In view of the prevalence of rotator cuff tear in osteoporotic elderly people, it is important to determine whether bisphosphonates affect rotator cuff tendon healing. However, no studies have investigated bisphosphonates’ cytotoxicity to human rotator cuff tendon fibroblasts (HRFs) or bisphosphonates’ effects on rotator cuff tendon healing. The purpose of this study was to evaluate the cytotoxicity of alendronate (Ald), a bisphosphonate, and its effects on HRF wound healing. Methods HRFs were obtained from human supraspinatus tendons, using primary cell cultures. The experimental groups were control, 0.1 μM Ald, 1 μM Ald, 10 μM Ald, and 100 μM Ald. Alendronate exposure was for 48 h, except during a cell viability analysis with durations from 1 day to 6 days. The experimental groups were evaluated for cell viability, cell cycle and cell proliferation, type of cell death, caspase activity, and wound-healing ability. Results The following findings regarding the 100 μM Ald group contrasted with those for all the other experimental groups: a significantly lower rate of live cells (p < 0.01), a higher rate of subG1 population, a lower rate of Ki-67 positive cells, higher rates of apoptosis and necrosis, a higher number of cells with DNA fragmentation, higher caspase-3/7 activity (p < 0.001), and a higher number of caspase-3 positive staining cells. In scratch-wound healing analyses of all the experimental groups, all the wounds healed within 48 h, except in the 100 μM Ald group (p < 0.001). Conclusions Low concentrations of alendronate appear to have little effect on HRF viability, proliferation, migration, and wound healing. However, high concentrations are significantly cytotoxic, impairing cellular proliferation, cellular migration, and wound healing in vitro.

Tissue engineering and rotator cuff tendon healing

2007 ◽  
Vol 16 (5) ◽  
pp. S204-S207 ◽  
Author(s):  
Joshua S. Dines ◽  
Daniel A. Grande ◽  
David M. Dines
Keyword(s):  
Tissue Engineering ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Rotator Cuff Tendon

scholarly journals The Effect of Purified Multi-potent Human Bone-marrow Derived Mesenchymal Stem Cells on Rotator Cuff Tendon Healing in an Athymic Rat

2016 ◽  
Vol 4 (7_suppl4) ◽  
pp. 2325967116S0014
Author(s):  
Ryan Degen ◽  
Andrew Carbone ◽  
Camilia Carballo ◽  
Jianchun Zong ◽  
Tony Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Rotator Cuff Tendon

scholarly journals Effect of highly purified capsaicin on articular cartilage and rotator cuff tendon healing: An in vivo rabbit study

2015 ◽  
Vol 33 (12) ◽  
pp. 1854-1860
Author(s):  
Nicole A. Friel ◽  
Allison G. McNickle ◽  
Michael J. DeFranco ◽  
FanChia Wang ◽  
Elizabeth F. Shewman ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Rotator Cuff Tendon
Sign in / Sign up

Export Citation Format

Share Document