scholarly journals Non-invasive tools for detection of liver disease in children and adolescents with cystic fibrosis

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Antonella Tosco ◽  
Angela Sepe ◽  
Alice Castaldo ◽  
Andrea Catzola ◽  
Chiara Cimbalo ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Children And Adolescents ◽  
Non Invasive

scholarly journals Nutritional Status of Children and Adolescents With Cystic Fibrosis Liver Disease (CFLD)

2011 ◽  
Vol 140 (5) ◽  
pp. S-863
Author(s):  
Alexandra Vasilescu ◽  
Peter Mogayzel ◽  
Kathryn A. Carson ◽  
Kathleen B. Schwarz
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Nutritional Status ◽  
Children And Adolescents ◽  
Nutritional Status Of Children

scholarly journals Non-Invasive Evaluation of Cystic Fibrosis Related Liver Disease in Adults with ARFI, Transient Elastography and Different Fibrosis Scores

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e42139 ◽  
Author(s):  
Thomas Karlas ◽  
Marie Neuschulz ◽  
Annett Oltmanns ◽  
Andrea Güttler ◽  
David Petroff ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Transient Elastography ◽  
Non Invasive ◽  
Related Liver Disease ◽  
Invasive Evaluation

scholarly journals Non-invasive Diagnostic Tests in Cystic Fibrosis-Related Liver Disease: A Diagnostic Test Accuracy Network Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ágnes Rita Martonosi ◽  
Alexandra Soós ◽  
Zoltán Rumbus ◽  
Péter Hegyi ◽  
Vera Izsák ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Diagnostic Test ◽  
Diagnostic Performance ◽  
Transient Elastography ◽  
Meta Analysis ◽  
Test Accuracy ◽  
Non Invasive ◽  
Related Liver Disease ◽  
New Criteria

Background and Aims: Cystic fibrosis-related liver disease (CFLD) is one of the leading causes of morbidity and mortality in cystic fibrosis (CF). Several non-invasive diagnostic methods have been proposed as screening tools for CFLD. Our aim was to rank all available non-invasive modalities for diagnostic performance.Methods: A systematic search was performed in five medical databases to find studies which reported on any single or composite non-invasive diagnostic test (as an index test) compared to the Debray, the EuroCare or the Colombo criteria (as a reference standard). Ranking was carried out with a Bayesian diagnostic test accuracy network meta-analysis based on superiority indices, calculated for pooled sensitivity (Se) and specificity (Sp) with a 95% confidence interval (CI). The study was registered under CRD42020155846 in PROSPERO.Results: Fifteen studies with 15 index tests and a combination of them were included. The New criteria proposed by Koh et al. – which represent a composite diagnostic definition for CFLD including liver biochemistry, ultrasonography, transient elastography and fibrosis markers—had the best performance for detecting CFLD (Se:94%[CI:58–100], Sp:72%[CI:52–84]); while transient elastography (Se:65%[CI:56–74], Sp:88%[CI:84–91]) and a combination of it with a tissue inhibitor of metalloproteinase-4 measurement (Se:78%[CI:30–100], Sp:64%[CI:18–95%]) proved to be the second and third best options, respectively. In the imaging techniques subgroup, transient elastography (Se:66%[CI:57–72], Sp:88%[CI:85–91%]), acoustic radiation force impulse in the right lobe (Se:54%[CI:33–74], Sp:88%[CI:66–96]) and that in the left lobe (Se:55%[CI:23–81], Sp:82%[CI:50–95]) were ranked the highest. Comparing biochemical markers/fibrosis indices, the measurement of the Forns index (Se:72%[CI:25–99], Sp:63%[CI:16–94]), the aspartate aminotransferase-to-platelet ratio (Se:55%[CI:41–68], Sp:83%[CI:66–89]) and alkaline phosphatase (Se:63%[CI:18–93], Sp:64%[CI:19–95]) were ranked the highest.Conclusion: The New criteria show the best diagnostic performance. In clinical practice, transient elastography seems to be a simple, cheap and non-invasive tool, outperforming imaging, biochemical and fibrosis tests for detecting CFLD. Further studies are needed to validate our findings.

scholarly journals EPS3.8 Non-invasive liver tests in cystic fibrosis-related liver disease (CFLD)

2017 ◽  
Vol 16 ◽  
pp. S43
Author(s):  
F. Frost ◽  
G.H. Jones ◽  
M.J. Ledson ◽  
D. Nazareth ◽  
M.J. Walshaw ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Non Invasive ◽  
Related Liver Disease ◽  
Liver Tests

A longitudinal assessment of non-invasive biomarkers to diagnose and predict cystic fibrosis-associated liver disease

2020 ◽  
Vol 19 (4) ◽  
pp. 546-552 ◽  
Author(s):  
Wikrom Karnsakul ◽  
Paul Wasuwanich ◽  
Thammasin Ingviya ◽  
Alexandra Vasilescu ◽  
Kathryn A. Carson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Longitudinal Assessment ◽  
Non Invasive

scholarly journals Non-invasive predictors of esophageous varices in children and adolescents with chronic liver disease or extrahepatic portal venous obstruction

2012 ◽  
Vol 88 (4) ◽  
pp. 341-6 ◽  
Author(s):  
Roberta V. Alcantara ◽  
Roberto M. Yamada ◽  
Adriana M. A. De Tommaso ◽  
Maria Angela Bellomo-Brandão ◽  
Gabriel Hessel
Keyword(s):  
Liver Disease ◽  
Children And Adolescents ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Venous Obstruction ◽  
Non Invasive ◽  
Extrahepatic Portal Venous Obstruction

TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease

2012 ◽  
Vol 44 (9) ◽  
pp. 780-787 ◽  
Author(s):  
Timo Rath ◽  
Katrin Menendez Menendez ◽  
Marion Kügler ◽  
Lisa Hage ◽  
Christian Wenzel ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Transient Elastography ◽  
Non Invasive
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