scholarly journals Relationship between bronchopulmonary dysplasia, long-term lung function, and vitamin D level at birth in preterm infants

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Tiantian Lu ◽  
Bin Liang ◽  
Yanping Jia ◽  
Jiangyun Cai ◽  
Danhong Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

scholarly journals Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial

Nutrients ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 1353 ◽  
Author(s):  
John Sluyter ◽  
Carlos Camargo ◽  
Debbie Waayer ◽  
Carlene Lawes ◽  
Les Toop ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Lung Function ◽  
Controlled Trial ◽  
High Dose ◽  
Randomized Controlled

scholarly journals Vitamin D and bronchopulmonary dysplasia in preterm infants

2016 ◽  
Vol 36 (10) ◽  
pp. 878-882 ◽  
Author(s):  
K E Joung ◽  
H H Burris ◽  
L J Van Marter ◽  
T F McElrath ◽  
Z Michael ◽  
...  
Keyword(s):  
Vitamin D ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

scholarly journals Long-term outcomes of bronchopulmonary dysplasia in preterm infants

2019 ◽  
pp. 43-52
Author(s):  
D.O. Dobryanskyy ◽  
◽  
A.O. Menshykova ◽  
O.P. Borysuk ◽  
◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Long Term Outcomes

scholarly journals Bronchopulmonary Dysplasia: Can We Agree on a Definition?

2018 ◽  
Vol 35 (06) ◽  
pp. 537-540 ◽  
Author(s):  
Deepak Jain ◽  
Eduardo Bancalari
Keyword(s):  
Respiratory Failure ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Nasal Cannula ◽  
Clinical Practices ◽  
Unique Challenge ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Respiratory Outcomes

AbstractThe advances in obstetric and neonatal care over the last half century have resulted in changes in pathophysiology and clinical presentation of bronchopulmonary dysplasia (BPD). In contrast to the original description of BPD by Northway et al as a severe lung injury in relatively mature preterm infants, the most common form of BPD currently is characterized by chronic respiratory insufficiency in extremely preterm infants. This evolution in the presentation of BPD, along with changes in respiratory support strategies such as increased use of nasal cannula oxygen, has presented a unique challenge to find a definition that describes the severity of lung damage and predict the long-term respiratory outcomes with some accuracy.The limitations of current definitions of BPD include inconsistent correlation with long-term respiratory outcomes, inability to classify infants dying from severe respiratory failure prior to 36 weeks' postmenstrual age, and potential inappropriate categorization of infants on nasal cannula oxygen or with extrapulmonary causes of respiratory failure. In the long term, the aim for a new definition of BPD is to develop a classification based on the pathophysiology and objective lung function evaluation providing a more accurate assessment for individual patients. Until then, a consensus definition that encompasses current clinical practices, provides reasonable prediction of later respiratory outcomes, and is relatively simple to use should be achieved.

Functional respiratory imaging provides novel insights into the long-term respiratory sequelae of bronchopulmonary dysplasia

2020 ◽  
pp. 2002110
Author(s):  
Kristien Vanhaverbeke ◽  
Monique Slaats ◽  
Mohammed Al-Nejar ◽  
Niek Everaars ◽  
Annemiek Snoeckx ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Lung Function ◽  
Bronchopulmonary Dysplasia ◽  
Functional Assessment ◽  
Airway Resistance ◽  
Ct Images ◽  
Air Trapping ◽  
Distal Airway ◽  
Conventional Ct

RationaleBronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Lung function and imaging are classically used to assess BPD. Functional Respiratory Imaging (FRI) combines a structural and functional assessment of the airways and their vasculature. We aimed to assess BPD with FRI and to correlate these findings with the clinical presentation.MethodsWe included 37 adolescents with a history of preterm birth (22 BPD cases and 15 preterm controls). The study protocol included a detailed history, lung function testing and CT (at TLC and FRC) with FRI. CT images were also assessed using the Aukland scoring system.ResultsBPD patients had lower FEV1/FVC (p=0.02) and impaired diffusion capacity (p=0.02).Aukland CT scores were not different between the two groups. FRI analysis showed higher lobar volumes in BPD patients at FRC (p<0.01) but not at TLC. Airway resistance was significantly higher in the BPD group, especially in the distal airways. Additionally, FRI showed more air trapping in BPD patients, in contrast to findings on conventional CT images.ConclusionThis study is the first to use FRI in research for BPD. FRI analysis showed higher lobar volumes in BPD patients, indicating air trapping and reduced inspiratory capacity. In contrast to Aukland CT scores, FRI showed more air trapping in the BPD group, suggesting that FRI might be a more sensitive detection method. Importantly, we also showed increased distal airway resistance in BPD patients. By combining structural and functional assessment, FRI may help to better understand the long-term sequelae of BPD.

Lung function gain in preterm infants with and without bronchopulmonary dysplasia

2016 ◽  
Vol 51 (9) ◽  
pp. 936-942 ◽  
Author(s):  
Manuel Sanchez-Solis ◽  
Virginia Perez-Fernandez ◽  
Vicente Bosch-Gimenez ◽  
Juan J. Quesada ◽  
Luis Garcia-Marcos
Keyword(s):  
Lung Function ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

scholarly journals Systematic review of the healthcare cost of bronchopulmonary dysplasia

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e045729
Author(s):  
Jhangir Humayun ◽  
Chatarina Löfqvist ◽  
David Ley ◽  
Ann Hellström ◽  
Hanna Gyllensten
Keyword(s):  
Systematic Review ◽  
Quality Assessment ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Gestational Age ◽  
First Year ◽  
Long Term Follow Up ◽  
First Year Of Life

ObjectivesTo determine the costs directly or indirectly related to bronchopulmonary dysplasia (BPD) in preterm infants. The secondary objective was to stratify the costs based on gestational age and/or birth weight.DesignSystematic literature review.SettingPubMed and Scopus were searched on 3 February 2020. Studies were selected based on eligibility criteria by two independent reviewers. Included studies were further searched to identify eligible references and citations.Two independent reviewers extracted data with a prespecified data extraction sheet, including items from a published checklist for quality assessment. The costs in the included studies are reported descriptively.Primary outcome measureCosts of BPD.ResultsThe 13 included studies reported the total costs or marginal costs of BPD. Most studies reported costs during birth hospitalisation (cost range: Int$21 392–Int$1 094 509 per child, equivalent to €19 103–€977 397, in 2019) and/or during the first year of life. One study reported costs during the first 2 years; two other studies reported costs later, during the preschool period and one study included a long-term follow-up. The highest mean costs were associated with infants born at extremely low gestational ages. The quality assessment indicated a low risk of bias in the reported findings of included studies.ConclusionsThis study was the first systematic review of costs associated with BPD. We confirmed previous reports of high costs and described the long-term follow-up necessary for preterm infants with BPD, particularly infants of very low gestational age. Moreover, we identified a need for studies that estimate costs outside hospitals and after the first year of life.PROSPERO registration numberCRD42020173234.

scholarly journals PS-206 Maternal/neonatal Vitamin D Deficiency May Be A Risk Factor For Development Of Bronchopulmonary Dysplasia In Preterm Infants

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A187.1-A187
Author(s):  
M Cetinkaya ◽  
A Demirhan ◽  
G Buyukkale ◽  
F Cekmez ◽  
T Erener-Ercan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia
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