Lung function gain in preterm infants with and without bronchopulmonary dysplasia

2016 ◽  
Vol 51 (9) ◽  
pp. 936-942 ◽  
Author(s):  
Manuel Sanchez-Solis ◽  
Virginia Perez-Fernandez ◽  
Vicente Bosch-Gimenez ◽  
Juan J. Quesada ◽  
Luis Garcia-Marcos
Keyword(s):  
Lung Function ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

ErbB4 deletion leads to changes in lung function and structure similar to bronchopulmonary dysplasia

2008 ◽  
Vol 294 (3) ◽  
pp. L516-L522 ◽  
Author(s):  
Erkhembulgan Purevdorj ◽  
Katja Zscheppang ◽  
Heinz G. Hoymann ◽  
Armin Braun ◽  
Dietlinde von Mayersbach ◽  
...  
Keyword(s):  
Animal Model ◽  
Growth Factor ◽  
Lung Function ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Cardiac Defects ◽  
Surfactant Synthesis ◽  
Old Adult

Neuregulin is an important growth factor in fetal surfactant synthesis, and downregulation of its receptor, ErbB4, impairs fetal surfactant synthesis. We hypothesized that pulmonary ErbB4 deletion will affect the developing lung leading to an abnormal postnatal lung function. ErbB4-deleted lungs of 11- to 14-wk-old adult HER4heart mice, rescued from their lethal cardiac defects, were studied for the effect on lung function, alveolarization, and the surfactant system. ErbB4 deletion impairs lung function and structure in HER4heart mice resulting in a hyperreactive airway system and alveolar simplification, as seen in preterm infants with bronchopulmonary dysplasia. It also leads to a downregulation of surfactant protein D expression and an underlying chronic inflammation in these lungs. Our findings suggest that this animal model could be used to further study the pathogenesis of bronchopulmonary dysplasia and might help design protective interventions.

scholarly journals Relationship between bronchopulmonary dysplasia, long-term lung function, and vitamin D level at birth in preterm infants

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Tiantian Lu ◽  
Bin Liang ◽  
Yanping Jia ◽  
Jiangyun Cai ◽  
Danhong Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

Fluid status in the first 10 days of life and death/bronchopulmonary dysplasia among preterm infants

2021 ◽  
Author(s):  
Safiya Soullane ◽  
Sharina Patel ◽  
Martine Claveau ◽  
Laila Wazneh ◽  
Guilherme Sant’Anna ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Life And Death ◽  
Fluid Status

scholarly journals Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial

2021 ◽  
Author(s):  
So Yoon Ahn ◽  
Yun Sil Chang ◽  
Myung Hee Lee ◽  
Se In Sung ◽  
Byong Sop Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Randomized Controlled

Characterization of lung ultrasound imaging in preterm infants with bronchopulmonary dysplasia

2021 ◽  
pp. 1-13
Author(s):  
Ying-Hua Sun ◽  
Lin Yuan ◽  
Yang Du ◽  
Jian-Guo Zhou ◽  
Sam Bill Lin ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Neonatal Intensive Care ◽  
Lung Ultrasound ◽  
Imaging Method ◽  
Chronic Lung Diseases ◽  
Pleural Line ◽  
Ultrasound Features

BACKGROUND: Lung ultrasound (LUS) is a bedside technique that can be used on diagnosis and follow-up of neonatal respiratory diseases. However, there are rare reports on the ultrasound features of bronchopulmonary dysplasia (BPD) which is one of the most common chronic lung diseases in preterm infants. OBJECTIVE: To describe the ultrasound features of different BPD levels, and to investigate the value of ultrasound in evaluating moderate-to-severe BPD. METHODS: In this prospective cohort study, newborns of less than 37 weeks’ gestational age in neonatal intensive care unit (NICU) were included. The LUS characteristics including pleural line, alveolar-interstitial syndrome (AIS), retrodiaphragmatic hyperechogenicity and diaphragmatic morphology were observed and recorded. The reliability of LUS in evaluating moderate and severe BPD were compared and calculated. RESULTS: A total of 108 infants were enrolled in our study: 39, 24, 29, 16 infants had non, mild, moderate and severe BPD. The median(IQR) pleura thickness in the moderate-to-severe BPD group was 1.7(1.6–1.85) mm, which was thicker than that in the none-to-mild BPD infants (P <  0.001), meanwhile the proportions of rough pleural lines, diffuse AIS, retrodiaphragmatic hyperechogenicity, small cysts above the diaphragm and rough diaphragm in the moderate-to-severe BPD group were also higher than those in none-to-mild BPD group (86.7% vs 36.5, 57.8% vs 7.9%, 37.8% vs 0, 33.3% vs 0, P <  0.001). In evaluating moderate-to-severe BPD, rough pleura had 91.1% (95% confidence interval [CI]: 0.793–0.965) in sensitivity, 91.3% (95% CI: 0.797–0.966) in negative predictive value (NPV), and 66.7% (95% CI: 0.544–0.771) in specificity. Small cysts had 100% (95% CI: 0.941-1) in specificity, 100% (95% CI: 0.816-1) in PPV, and 37.8% in sensitivity (95% CI: 0.251–0.524). Rough diaphragm had 100% (95% CI: 0.943-1) in sensitivity, 100% (95% CI: 0.796-1) in PPV and 33.3% (95% CI: 0.211–0.478) in specificity. CONCLUSIONS: Depending on its unique advantages such as convenient, no radiation and repeatable, LUS is a valuable imaging method in assessing the severity of BPD, especially in moderate and severe BPD.

Higher Altitude and Risk of Bronchopulmonary Dysplasia among Preterm Infants

2012 ◽  
Vol 30 (07) ◽  
pp. 601-606 ◽  
Author(s):  
Shoo Lee ◽  
Xiang Ye ◽  
Nalini Singhal ◽  
Sarah De La Rue ◽  
Abhay Lodha ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia
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