scholarly journals Characteristics of the intestinal microbiota and metabolism in infants with extrauterine growth restriction

2021 ◽  
Vol 10 (5) ◽  
pp. 1259-1270
Author(s):  
Sainan Fan ◽  
Kun Zhang ◽  
Anping Lv ◽  
Yanan Ma ◽  
Xiaohui Fang ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Growth Restriction ◽  
Extrauterine Growth Restriction

scholarly journals Characteristics of the Intestinal Microbiota and Metabolism in Infants with Extrauterine Growth Restriction

2020 ◽  
Author(s):  
Sainan Fan ◽  
Kun Zhang ◽  
Anping Lv ◽  
Yanan Ma ◽  
Xiaohui Fang ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Intestinal Microbiota ◽  
Neonatal Intensive Care ◽  
Bacterial Species ◽  
Postnatal Growth ◽  
Growth Restriction ◽  
Microbial Species ◽  
Metagenome Sequencing ◽  
Extrauterine Growth Restriction

Abstract Objective Infants with extrauterine growth restriction (EUGR) experience significant postnatal growth restriction in the first week after birth, which indicates a failure of energy absorption. This study aimed to determine the different intestinal microbial species and metabolites between infants with EUGR and those without EUGR. Methods A total of 73 infants hospitalized in a neonatal intensive care unit were enrolled and divided into the EUGR group (n = 50) and the non-EUGR group (n = 23). Fecal samples were collected during hospitalization. Bacterial species and their relative abundance were identified with metagenome sequencing. The metabolites in the feces and blood were identified with an LC-MS–based non-targeted metabolome. Results The intestinal microbiota of the EUGR group contained less Bacteroides vulgatus, Dorea unclassified, Lachnospiraceae bacterium 1_1_57FAA, and Roseburia unclassified compared to that of the non-EUGR group. More importantly, the intestinal microbiota of the EUGR group contained Streptococcus mitis_oralis_pneumoniae, while that of the non-EUGR group did not. Furthermore, KEGG prediction and a correlation analysis identified that the majority of different microbial species higher in the non-EUGR group were related to metabolism. The results of the non-targeted metabolome revealed that several metabolites in the feces and blood were much higher in either group, some of which were related to the different microbial species. Conclusions This study identified several different intestinal microbial species and metabolites in the patients feces and blood, which may provide evidence to identify the biomarkers of infants with EUGR.

scholarly journals Extrauterine growth restriction among neonates with a birthweight less than 1500 grams

2018 ◽  
Vol 89 (6) ◽  
pp. 325-332 ◽  
Author(s):  
Alejandro Avila-Alvarez ◽  
Alfonso Solar Boga ◽  
Carmen Bermúdez-Hormigo ◽  
Jesús Fuentes Carballal
Keyword(s):  
Growth Restriction ◽  
Extrauterine Growth Restriction

Quality Initiative to Reduce Extrauterine Growth Restriction in Very Low Birth Weight Infants

2022 ◽  
Author(s):  
Ramasubbareddy Dhanireddy ◽  
Patricia A. Scott ◽  
Brenda Barker ◽  
Theresa A. Scott
Keyword(s):  
Birth Weight ◽  
Primary Outcome ◽  
Very Low Birth Weight ◽  
Caloric Intake ◽  
Growth Restriction ◽  
Quality Improvement Initiative ◽  
Low Birth Weight Infants ◽  
Process Measures ◽  
Extrauterine Growth Restriction ◽  
Parenteral Protein

BACKGROUND: We report a statewide quality improvement initiative aimed to decrease the incidence of extrauterine growth restriction among very low birth weight infants cared for in Tennessee NICUs. METHODS: The cohort consisted of infants born appropriate for gestational age between May 2016 and December 2018 from 9 NICUs across Tennessee. The infants were 23 to 32 weeks gestation and 500 to 1499 g birth weight. The process measures were the hours of life (HOL) when parenteral protein and intravenous lipid emulsion were initiated, the number of days to first enteral feeding, and attainment of full enteral caloric intake (110–130 kcal/kg per day). The primary outcome was extrauterine growth restriction, defined as weight <10th percentile for weight at 36 weeks postmenstrual age. Statistical process control charts and the Shewhart control rules were used to find special cause variation. RESULTS: Although special cause variation was not indicated in the primary outcome measure, it was indicated for the reduction in specific process measures: HOL when parenteral protein was initiated, HOL when intravenous lipid emulsion was initiated, and the number of days to attainment of full enteral caloric intake (among the hospitals considered regional perinatal centers). CONCLUSIONS: A statewide quality improvement initiative led to earlier initiation of parenteral and enteral nutrition and improved awareness of the importance of postnatal nutrition.

Extrauterine growth restriction was associated with short stature and thinness in very low birthweight infants at around six years of age

2018 ◽  
Vol 108 (1) ◽  
pp. 112-117 ◽  
Author(s):  
Toshimitsu Takayanagi ◽  
Akinori Shichijo ◽  
Masakazu Egashira ◽  
Tomoko Egashira ◽  
Tomoko Mizukami
Keyword(s):  
Short Stature ◽  
Low Birthweight ◽  
Growth Restriction ◽  
Very Low Birthweight ◽  
Very Low Birthweight Infants ◽  
Extrauterine Growth Restriction

scholarly journals Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children

2020 ◽  
Vol 8 ◽  
Author(s):  
Maria D. Ordóñez-Díaz ◽  
Juan L. Pérez-Navero ◽  
Katherine Flores-Rojas ◽  
Josune Olza-Meneses ◽  
Maria C. Muñoz-Villanueva ◽  
...  
Keyword(s):  
Growth Restriction ◽  
Low Grade ◽  
Prepubertal Children ◽  
Extrauterine Growth Restriction

“Extrauterine growth restriction” and “postnatal growth failure” are misnomers for preterm infants

2020 ◽  
Vol 40 (5) ◽  
pp. 704-714 ◽  
Author(s):  
Tanis R. Fenton ◽  
Barbara Cormack ◽  
Dena Goldberg ◽  
Roseann Nasser ◽  
Belal Alshaikh ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Growth Failure ◽  
Postnatal Growth ◽  
Growth Restriction ◽  
Extrauterine Growth Restriction ◽  
Postnatal Growth Failure

scholarly journals Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1224 ◽  
Author(s):  
Chiara Peila ◽  
Elena Spada ◽  
Francesca Giuliani ◽  
Giulia Maiocco ◽  
Melissa Raia ◽  
...  
Keyword(s):  
Very Low Birth Weight ◽  
Growth Restriction ◽  
Preterm Neonates ◽  
Low Birth Weight Infants ◽  
Term Outcome ◽  
Cross Sectional ◽  
Long Term Outcome ◽  
Nutritional Interventions ◽  
Definition Of ◽  
Extrauterine Growth Restriction

Extrauterine Growth Restriction (EUGR) refers to inadequate growth during hospitalization. Current definitions for EUGR are varied and can be classified as cross-sectional (weight at a given t-time <10th centile) or longitudinal (weight loss between birth and a given t-time >1SD). Different t-times are also considered in literature, such as 36 weeks of gestational age (GA) or age at discharge. The aim of this study is to investigate whether EUGR could predict the auxological outcome at 24–30 months, and to evaluate the agreement between cross-sectional and longitudinal definitions. In total, 1589 infants with GA <30 weeks or birthweight ≤ 1500 g and without major congenital anomalies were included in this study. Cross-sectional and longitudinal EUGR were calculated at 36 and 40 weeks of GA, at discharge, and at 28 days. The concordance between the two definitions was estimated by Kappa coefficient. At 24–30 months, 803 infants were measured again. The agreement between the two definitions of EUGR was low. Both EUGR and not-EUGR groups were at lower centiles for weight, but at higher centiles for head circumference at 24–30 months than at birth. Longitudinal EUGR was associated with a poorer growth outcome for weight and height circumference than cross-sectional EUGR. No differences were observed for length. An agreed definition of EUGR is highly desirable in clinical practice to assess medical and nutritional interventions in preterm neonates. Based on the results of this study, we recommend the use of the longitudinal evaluation, that proved to better predict the auxological long-term outcome with respect to the cross-sectional one.

Extrauterine Growth Restriction in Low Birth Weight Infants

2019 ◽  
Vol 38 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Kari Bonnar ◽  
Debbie Fraser
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
Growth Failure ◽  
Postnatal Growth ◽  
Growth Restriction ◽  
Low Birth Weight Infants ◽  
Extrauterine Growth Restriction ◽  
Postnatal Growth Failure

Extrauterine growth restriction (EUGR) affects a significant number of very low birth weight (VLBW) infants and has the potential to impact neurodevelopmental outcome as well as other aspects of long-term health. More aggressive nutritional approaches have reduced the incidence of postnatal growth failure but many questions remain about the expected rate of growth for very preterm infants, the best ways to measure growth velocity, and the optimal approaches to supporting growth. This article examines some of the outstanding issues regarding postnatal growth failure and summarizes current practice recommendations.

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