scholarly journals Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

2020 ◽  
Vol 4 ◽  
pp. 2-2
Author(s):  
Yike Huang ◽  
Ting Wang ◽  
María Elizabeth Urbina López ◽  
Minoru Hirano ◽  
Anwarul Hasan ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Drug Screening ◽  
Human Ipsc

scholarly journals Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening

2017 ◽  
Vol 35 (1) ◽  
pp. 77-94 ◽  
Author(s):  
Alec S.T. Smith ◽  
Jesse Macadangdang ◽  
Winnie Leung ◽  
Michael A. Laflamme ◽  
Deok-Ho Kim
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Disease Modeling ◽  
Human Ipsc

scholarly journals Author Correction: Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hendrik Lapp ◽  
Tobias Bruegmann ◽  
Daniela Malan ◽  
Stephanie Friedrichs ◽  
Carsten Kilgus ◽  
...  
Keyword(s):  
Drug Screening ◽  
Frequency Dependent ◽  
Optogenetic Stimulation ◽  
Human Ipsc ◽  
Stimulation Of

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A microfluidic gradient device for drug screening with human iPSC-derived motoneurons

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 3081-3089 ◽  
Author(s):  
Sung Joon Mo ◽  
Ju-Hyun Lee ◽  
Hyeon Gi Kye ◽  
Jong Min Lee ◽  
Eun-Joong Kim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Drug Screening ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Screening System ◽  
Induced Pluripotent ◽  
Gradient Device ◽  
Human Ipsc

We developed a microfluidic gradient device to utilize as a drug screening system with human induced pluripotent stem cell (hiPSC)-derived motoneurons.

scholarly journals Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hendrik Lapp ◽  
Tobias Bruegmann ◽  
Daniela Malan ◽  
Stephanie Friedrichs ◽  
Carsten Kilgus ◽  
...  
Keyword(s):  
Drug Screening ◽  
Frequency Dependent ◽  
Optogenetic Stimulation ◽  
Human Ipsc ◽  
Stimulation Of

scholarly journals Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Anurag Mathur ◽  
Peter Loskill ◽  
Kaifeng Shao ◽  
Nathaniel Huebsch ◽  
SoonGweon Hong ◽  
...  
Keyword(s):  
Drug Screening ◽  
Human Ipsc

scholarly journals A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jong-Chan Park ◽  
So-Yeong Jang ◽  
Dongjoon Lee ◽  
Jeongha Lee ◽  
Uiryong Kang ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Screening ◽  
Pathological Features ◽  
Screening Platform ◽  
Approved Drugs ◽  
Effective Drugs ◽  
Human Ipsc ◽  
Fda Approved Drugs

AbstractDeveloping effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, we report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of AD with human iPSC-derived cerebral organoids (iCOs), including CRISPR-Cas9-edited isogenic lines. We use 1300 organoids from 11 participants to build a high-content screening (HCS) system and test blood–brain barrier-permeable FDA-approved drugs. Our study provides a strategy for precision medicine through the convergence of mathematical modeling and a miniature pathological brain model using iCOs.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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