scholarly journals Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Anurag Mathur ◽  
Peter Loskill ◽  
Kaifeng Shao ◽  
Nathaniel Huebsch ◽  
SoonGweon Hong ◽  
...  
Keyword(s):  
Drug Screening ◽  
Human Ipsc

scholarly journals Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

2020 ◽  
Vol 4 ◽  
pp. 2-2
Author(s):  
Yike Huang ◽  
Ting Wang ◽  
María Elizabeth Urbina López ◽  
Minoru Hirano ◽  
Anwarul Hasan ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Drug Screening ◽  
Human Ipsc

scholarly journals Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening

2017 ◽  
Vol 35 (1) ◽  
pp. 77-94 ◽  
Author(s):  
Alec S.T. Smith ◽  
Jesse Macadangdang ◽  
Winnie Leung ◽  
Michael A. Laflamme ◽  
Deok-Ho Kim
Keyword(s):  
Tissue Engineering ◽  
Drug Screening ◽  
Disease Modeling ◽  
Human Ipsc

scholarly journals Author Correction: Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hendrik Lapp ◽  
Tobias Bruegmann ◽  
Daniela Malan ◽  
Stephanie Friedrichs ◽  
Carsten Kilgus ◽  
...  
Keyword(s):  
Drug Screening ◽  
Frequency Dependent ◽  
Optogenetic Stimulation ◽  
Human Ipsc ◽  
Stimulation Of

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A microfluidic gradient device for drug screening with human iPSC-derived motoneurons

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 3081-3089 ◽  
Author(s):  
Sung Joon Mo ◽  
Ju-Hyun Lee ◽  
Hyeon Gi Kye ◽  
Jong Min Lee ◽  
Eun-Joong Kim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Drug Screening ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Screening System ◽  
Induced Pluripotent ◽  
Gradient Device ◽  
Human Ipsc

We developed a microfluidic gradient device to utilize as a drug screening system with human induced pluripotent stem cell (hiPSC)-derived motoneurons.

scholarly journals Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hendrik Lapp ◽  
Tobias Bruegmann ◽  
Daniela Malan ◽  
Stephanie Friedrichs ◽  
Carsten Kilgus ◽  
...  
Keyword(s):  
Drug Screening ◽  
Frequency Dependent ◽  
Optogenetic Stimulation ◽  
Human Ipsc ◽  
Stimulation Of

scholarly journals A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jong-Chan Park ◽  
So-Yeong Jang ◽  
Dongjoon Lee ◽  
Jeongha Lee ◽  
Uiryong Kang ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Screening ◽  
Pathological Features ◽  
Screening Platform ◽  
Approved Drugs ◽  
Effective Drugs ◽  
Human Ipsc ◽  
Fda Approved Drugs

AbstractDeveloping effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, we report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of AD with human iPSC-derived cerebral organoids (iCOs), including CRISPR-Cas9-edited isogenic lines. We use 1300 organoids from 11 participants to build a high-content screening (HCS) system and test blood–brain barrier-permeable FDA-approved drugs. Our study provides a strategy for precision medicine through the convergence of mathematical modeling and a miniature pathological brain model using iCOs.

Sign in / Sign up

Export Citation Format

Share Document