AB195. 194. Clinicopathological features and management of metaplastic breast cancer: a single institution experience

2018 ◽  
Vol 2 ◽  
pp. AB195-AB195
Author(s):  
Niamh Siobhan Buckley ◽  
Syer Ree Tee ◽  
Anne O’Doherty ◽  
Cecilly Quinn ◽  
Jane Rothwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinicopathological Features ◽  
Single Institution ◽  
Metaplastic Breast Cancer

Metaplastic breast cancer: A single-institution experience.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12575-e12575
Author(s):  
Aumilto Augusto Silva ◽  
Rudinei Diogo Marques Linck ◽  
Julianne Maria da Silva Lima ◽  
Adriana Reis Brandao Matutino ◽  
Saulo Brito Silva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Institution ◽  
Metaplastic Breast Cancer

Survival outcomes of metaplastic breast carcinoma: An Indian tertiary care center data.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12579-e12579
Author(s):  
Lalnun Puii ◽  
Vinu Sarathy ◽  
Lalram Sangi ◽  
Beulah Elsa Thomas ◽  
Samuel Luke Koramati ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Triple Negative ◽  
Locally Advanced ◽  
Clinicopathological Features ◽  
Survival Outcomes ◽  
Metaplastic Breast Cancer ◽  
Her 2 ◽  
Clinical Records ◽  
Metaplastic Breast Carcinoma

e12579 Background: Metaplastic breast carcinoma is a rare histological subtype that has basal like characteristics and is reported to have a poorer prognosis than no specific type/ductal carcinoma (ductal/NST). We aimed to investigate clinicopathological features and outcome from a single institution based registry. Methods: Clinical records of breast cancer patients treated during 2012-2019 were screened and 31 cases of metaplastic breast carcinoma were found. Descriptive analysis was done for patients’ demographics and clinicopathological features. Kaplan Meier method was used to assess survival outcomes. Results: The incidence of metaplastic breast cancer was 0.5% (31/6180) in our study out of which the most common histopathological differentiation was squamous (45.16%). The second most common was sarcomatoid histology (32.25%), followed by chondroid (9.68%) and mixed histology (12.9%). The median age at diagnosis was 60 years ranging from 28 to 82 years. 64.15% of patients were post-menopausal. At presentation, three (9.67%) patients had metastatic disease while the rest were diagnosed with early (51.61%) and locally advanced cancers (38.72%). Triple negative cancers (ER/PR/Her2 negative) constituted the vast majority with 22 cases (80.6%) while hormone receptor positive (ER/PR positive, Her-2 negative) and Her-2 neu positive (ER/PR negative) made up the rest with three patients (9.67%) each group respectively. The median overall survival was found to be 39 months (95% CI 25.46 - 52.53). Conclusions: After a thorough search in PubMed and Google Scholar, we could not find a larger case series from India with clinical outcomes for metaplastic breast carcinoma. Our results suggest that metaplastic breast carcinoma is a heterogenous disease. Outcomes of metaplastic breast carcinoma are relatively worse when compared with literature for triple negative breast cancer and breast cancer in general. Further biological understanding may offer valuable insights for newer targets and therapeutic approaches to metaplastic breast cancer.

Metaplastic Breast Cancer: Molecular Typing and Identification of Potential Targeted Therapies at a Single Institution

2017 ◽  
Vol 17 (1) ◽  
pp. e1-e10 ◽  
Author(s):  
Jessica Edenfield ◽  
Christine Schammel ◽  
Justin Collins ◽  
David Schammel ◽  
W. Jeff Edenfield
Keyword(s):  
Breast Cancer ◽  
Targeted Therapies ◽  
Molecular Typing ◽  
Single Institution ◽  
Metaplastic Breast Cancer

scholarly journals Assessment of outcomes and novel immune biomarkers in metaplastic breast cancer: a single institution retrospective study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Evan Morgan ◽  
Anupama Suresh ◽  
Akaansha Ganju ◽  
Daniel G. Stover ◽  
Robert Wesolowski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Single Institution ◽  
Metaplastic Breast Cancer ◽  
Immune Biomarkers

Metaplastic breast cancer: clinicopathological features and its prognosis

2012 ◽  
Vol 65 (5) ◽  
pp. 441-446 ◽  
Author(s):  
Hyewon Lee ◽  
So-Youn Jung ◽  
Jae Yun Ro ◽  
Youngmee Kwon ◽  
Joo Hyuk Sohn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinicopathological Features ◽  
Metaplastic Breast Cancer

Clinicopathological and Imaging Features Predictive of Clinical Outcome in Metaplastic Breast Cancer

2020 ◽  
Vol 16 (6) ◽  
pp. 729-738
Author(s):  
Ga Young Yoon ◽  
Joo Hee Cha ◽  
Hak Hee Kim ◽  
Hee Jung Shin ◽  
Eun Young Chae ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Clinical Outcomes ◽  
Tumor Size ◽  
Multivariable Analysis ◽  
Disease Free Survival ◽  
Imaging Features ◽  
Peritumoral Edema ◽  
Imaging Findings ◽  
Metaplastic Breast Cancer

Background: Metaplastic breast cancer (MC) is a rare disease, thus it is difficult to study its clinical outcomes. Objective: To investigate whether any clinicopathological or imaging features were associated with clinical outcome in MC. Methods: We retrospectively evaluated the clinicopathological and imaging findings, and the clinical outcomes of seventy-two pathologically confirmed MCs. We then compared these parameters between triple-negative (TNMC) and non-TNMCs (NTNMC). Results: Oval or round shape, and not-circumscribed margin were the most common findings on mammography, ultrasound (US), and magnetic resonance imaging (MRI). It was mostly a mass without calcification on mammography, and revealed complex or hypoechoic echotexture, and posterior acoustic enhancement on US, and rim enhancement, wash-out kinetics, peritumoral edema, and intratumoral necrosis on MRI. Of all 72, 64 were TNMCs, and eight were NTNMCs. Clinicopathological and imaging findings were similar between the two groups, except that MRI showed peritumoral edema more frequently in TNMCs than NTNMCs (p=0.045). There were 21 recurrences and 13 deaths. Multivariable analysis showed that larger tumor size and co-existing DCIS were significantly predictive of Disease free survival (DFS), and larger tumor size and neoadjuvant chemotherapy were significantly predictive of overall survival (OS). Conclusion: MC showed characteristic imaging findings, and some variables associated with survival outcome may help to predict prognosis.

Sign in / Sign up

Export Citation Format

Share Document