Metaplastic Breast Cancer: Molecular Typing and Identification of Potential Targeted Therapies at a Single Institution

2017 ◽  
Vol 17 (1) ◽  
pp. e1-e10 ◽  
Author(s):  
Jessica Edenfield ◽  
Christine Schammel ◽  
Justin Collins ◽  
David Schammel ◽  
W. Jeff Edenfield
Keyword(s):  
Breast Cancer ◽  
Targeted Therapies ◽  
Molecular Typing ◽  
Single Institution ◽  
Metaplastic Breast Cancer

AB195. 194. Clinicopathological features and management of metaplastic breast cancer: a single institution experience

2018 ◽  
Vol 2 ◽  
pp. AB195-AB195
Author(s):  
Niamh Siobhan Buckley ◽  
Syer Ree Tee ◽  
Anne O’Doherty ◽  
Cecilly Quinn ◽  
Jane Rothwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinicopathological Features ◽  
Single Institution ◽  
Metaplastic Breast Cancer

Metaplastic breast cancer: A single-institution experience.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12575-e12575
Author(s):  
Aumilto Augusto Silva ◽  
Rudinei Diogo Marques Linck ◽  
Julianne Maria da Silva Lima ◽  
Adriana Reis Brandao Matutino ◽  
Saulo Brito Silva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Institution ◽  
Metaplastic Breast Cancer

Metaplastic breast cancer: an old histotype but a current therapeutic problem

2021 ◽  
Vol 17 (8) ◽  
pp. 955-963
Author(s):  
Gennaro Gadaleta-Caldarola ◽  
Rosanna Nenna ◽  
Laura Lanotte ◽  
Antonio Doronzo ◽  
Arianna Gadaleta-Caldarola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapies ◽  
Triple Negative ◽  
Tumor Infiltrating Lymphocytes ◽  
Molecular Signature ◽  
Molecular Heterogeneity ◽  
Tumor Type ◽  
Metaplastic Breast Cancer ◽  
Molecular Features ◽  
Therapeutic Problem

Metaplastic breast cancer (MPBC) is a rare and aggressive tumor type in great need of satisfactory therapies. Although most cases of MPBC are ‘triple negative’, they are nonetheless related to worse outcomes compared with other triple-negative invasive tumors. MPBC presents high levels of genetic and molecular heterogeneity, suggesting that novel targeted therapies can be exploited. Overexpression of PD-L1 and high levels of tumor-infiltrating lymphocytes have also been observed in these tumors, suggesting a role for immunotherapy. We present an updated literature revision on clinical, histopathological and molecular features of MPBC and their significance to prognosis and therapy options. We discuss emerging efforts to improve and personalize prognostic and therapeutic approaches, exploiting the molecular signature of MPBC with targeted therapies and immunotherapies.

scholarly journals Assessment of outcomes and novel immune biomarkers in metaplastic breast cancer: a single institution retrospective study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Evan Morgan ◽  
Anupama Suresh ◽  
Akaansha Ganju ◽  
Daniel G. Stover ◽  
Robert Wesolowski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Single Institution ◽  
Metaplastic Breast Cancer ◽  
Immune Biomarkers

Clinicopathological and Imaging Features Predictive of Clinical Outcome in Metaplastic Breast Cancer

2020 ◽  
Vol 16 (6) ◽  
pp. 729-738
Author(s):  
Ga Young Yoon ◽  
Joo Hee Cha ◽  
Hak Hee Kim ◽  
Hee Jung Shin ◽  
Eun Young Chae ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Clinical Outcomes ◽  
Tumor Size ◽  
Multivariable Analysis ◽  
Disease Free Survival ◽  
Imaging Features ◽  
Peritumoral Edema ◽  
Imaging Findings ◽  
Metaplastic Breast Cancer

Background: Metaplastic breast cancer (MC) is a rare disease, thus it is difficult to study its clinical outcomes. Objective: To investigate whether any clinicopathological or imaging features were associated with clinical outcome in MC. Methods: We retrospectively evaluated the clinicopathological and imaging findings, and the clinical outcomes of seventy-two pathologically confirmed MCs. We then compared these parameters between triple-negative (TNMC) and non-TNMCs (NTNMC). Results: Oval or round shape, and not-circumscribed margin were the most common findings on mammography, ultrasound (US), and magnetic resonance imaging (MRI). It was mostly a mass without calcification on mammography, and revealed complex or hypoechoic echotexture, and posterior acoustic enhancement on US, and rim enhancement, wash-out kinetics, peritumoral edema, and intratumoral necrosis on MRI. Of all 72, 64 were TNMCs, and eight were NTNMCs. Clinicopathological and imaging findings were similar between the two groups, except that MRI showed peritumoral edema more frequently in TNMCs than NTNMCs (p=0.045). There were 21 recurrences and 13 deaths. Multivariable analysis showed that larger tumor size and co-existing DCIS were significantly predictive of Disease free survival (DFS), and larger tumor size and neoadjuvant chemotherapy were significantly predictive of overall survival (OS). Conclusion: MC showed characteristic imaging findings, and some variables associated with survival outcome may help to predict prognosis.

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