scholarly journals The impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the diagnosis of thyroid nodules

Gland Surgery ◽  
2019 ◽  
Vol 8 (S2) ◽  
pp. S86-S97 ◽  
Author(s):  
Marc Pusztaszeri ◽  
Massimo Bongiovanni
Keyword(s):  
Thyroid Nodules ◽  
Thyroid Neoplasm ◽  
Non Invasive ◽  
The Impact ◽  
Nuclear Features

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): impact on the reclassification of thyroid nodules

2018 ◽  
Vol 25 (4) ◽  
pp. R247-R258 ◽  
Author(s):  
Isabel Amendoeira ◽  
Tiago Maia ◽  
Manuel Sobrinho-Simões
Keyword(s):  
Thyroid Neoplasm ◽  
Molecular Testing ◽  
Predictive Values ◽  
Non Invasive ◽  
Molecular Tests ◽  
Endocrine Organs ◽  
The Impact ◽  
Nuclear Features

The 2017 edition of the WHO book on Classification of Tumours of Endocrine Organs includes a new section entitled ‘Other encapsulated follicular-patterned thyroid tumours’, in which the newly created NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is identified and described in detail. Despite deleting the word ‘carcinoma’ from its name, NIFTP is not a benign tumor either and is best regarded as a neoplasm with ‘very low malignant potential’. The main goal of the introduction of NIFTP category is to prevent overdiagnosis and overtreatment. Sampling constraints, especially when dealing with heterogeneous and/or large nodules, and difficulties in the invasiveness evaluation, are the major weaknesses of the histological characterization of NIFTP. At the cytological level, NIFTP can be separated from classic papillary carcinoma (cPTC) but not from encapsulated, invasive follicular variant PTC. The impact of NIFTP individualization for cytopathology is the drop of rates of malignancy for each Bethesda category in general and for indeterminate categories in particular. The biggest impact will be seen in institutions with a high frequency of FVPTC. The introduction of NIFTP has changed the utility of predictive values of molecular tests because RAS mutations and PAX8-PPARg rearrangements are frequently detected in NIFTP. This turns less promising the application of mutation detection panels as indicators of malignancy and will probably contribute to switch to a rule-out approach of molecular testing. Selection for surgery will go on being determined by a combined detection of clinical, cytological and ultrasound suspicious features.

scholarly journals Risk of Malignancy in Thyroid Nodules Using the American College of Radiology Thyroid Imaging Reporting and Data System in the NIFTP Era

2018 ◽  
Vol 50 (10) ◽  
pp. 735-737 ◽  
Author(s):  
Pedro Rosario ◽  
Alexandre da Silva ◽  
Maurício Nunes ◽  
Michelle Borges
Keyword(s):  
Thyroid Nodules ◽  
Data System ◽  
Thyroid Neoplasm ◽  
Malignant Tumours ◽  
Thyroid Imaging ◽  
Risk Of Malignancy ◽  
Nuclear Features

AbstractRecently, the American College of Radiology (ACR) proposed a Thyroid Imaging Reporting and Data System (TI-RADS) for thyroid nodules based on ultrasonographic features. It is important to validate this classification in different centres. The present study evaluated the risk of malignancy in solid nodules>1 cm using ACR TI-RADS. The risk of malignancy was defined including noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and after its exclusion from malignant tumours. For the present study, the original images were revised, and each nodule was assigned to one of the TI-RADS levels proposed for solid nodules: TR3, TR4, or TR5. This risk of malignancy was significantly different for the three levels: 1.7%, 11.2%, and 60.6% for TR3, TR4, and TR5, respectively, when NIFTP was included, and 0.6%, 7.9%, and 60.2% for TR3, TR4, and TR5, respectively, when NIFTP was excluded from malignant tumours. The nodules corresponding to NIFTP were classified according to ACR as TR3 in 28.5% of cases, TR4 in 67.8%, and TR5 in only 3.5%. The nodules corresponding to cancer were classified according to ACR as TR3 in only 2.3% of cases, TR4 in 27%, and TR5 in 70.5%. In conclusion, this study shows the validity of the ACR TI-RADS for solid thyroid nodules, even after the exclusion of NIFTP from malignant tumours.

Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)

2018 ◽  
Vol 29 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Kyle C. Strickland ◽  
Markus Eszlinger ◽  
Ralf Paschke ◽  
Trevor E. Angell ◽  
Erik K. Alexander ◽  
...  
Keyword(s):  
Thyroid Neoplasm ◽  
Molecular Testing ◽  
Cytologic Diagnosis ◽  
Non Invasive ◽  
Nuclear Features

scholarly journals Comprehensive analysis for diagnosis of preoperative non-invasive follicular thyroid neoplasm with papillary-like nuclear features

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0218046 ◽  
Author(s):  
Hye Seung Lee ◽  
Jae-Wook Lee ◽  
Ji Hyun Park ◽  
Wan-Seop Kim ◽  
Hye Seung Han ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Thyroid Neoplasm ◽  
Non Invasive ◽  
Nuclear Features

The Morphologic Analysis of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features(NIFTP) on FNAC: Our Institutional Experience

2016 ◽  
Vol 5 (5) ◽  
pp. S84-S85
Author(s):  
Esther Rossi ◽  
Tommaso Bizzarro ◽  
Maurizio Martini ◽  
Celestino Lombardi ◽  
Alfredo Pontecorvi ◽  
...  
Keyword(s):  
Thyroid Neoplasm ◽  
Non Invasive ◽  
Institutional Experience ◽  
Morphologic Analysis ◽  
Nuclear Features
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