Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features

2017 ◽  
Vol 30 (6) ◽  
pp. 810-825 ◽  
Author(s):  
Uiju Cho ◽  
Ozgur Mete ◽  
Min-Hee Kim ◽  
Ja Seong Bae ◽  
Chan Kwon Jung
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Neoplasm ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Non Invasive ◽  
Node Metastasis ◽  
The Impact ◽  
Nuclear Features

Factors predictive of lymph node metastasis in the follicular variant of papillary thyroid carcinoma

2013 ◽  
Vol 100 (10) ◽  
pp. 1312-1317 ◽  
Author(s):  
C. Blanchard ◽  
C. Brient ◽  
C. Volteau ◽  
F. Sebag ◽  
M. Roy ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Node Metastasis

scholarly journals Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)

2021 ◽  
Vol 12 ◽  
pp. 204201882110005
Author(s):  
Eunju Jang ◽  
Kwangsoon Kim ◽  
Chan Kwon Jung ◽  
Ja Seong Bae ◽  
Jeong Soo Kim
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Preoperative Diagnosis ◽  
Clinicopathological Characteristics ◽  
Thyroid Neoplasm ◽  
Clinicopathological Parameters ◽  
Follicular Variant ◽  
Non Invasive ◽  
Node Metastasis ◽  
Pathology Reports

Background: Criteria for the preoperative diagnosis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) have not yet been confirmed. This study aimed to analyze differences in clinicopathological characteristics between follicular variant of papillary thyroid carcinoma (FVPTC) subtypes to determine which parameters are relevant in differentiating NIFTP from other variants. Methods: We retrospectively analyzed the records of 199 patients with a preoperative diagnosis of FVPTC who underwent thyroid surgery at Seoul St. Mary’s Hospital (Seoul, Korea) from 2011 to 2015. Clinicopathological features were analyzed retrospectively via a complete review of medical charts and pathology reports of patients. Results: The NIFTP and invasive encapsulated FVPTC (EFVPTC) groups showed relatively benign features, with a majority of the patients categorized as Bethesda category III (25.8% and 25.6%, respectively) or IV (34.8% and 30.2%, respectively), while the infiltrative FVPTC group showed more malignant features, with more patients categorized as category V (28.6%) or VI (47.6%) ( p < 0.001). BRAF V600E mutations were significantly less prevalent in the NIFTP group (0%) and invasive EFVPTC group (4.7%) compared with the infiltrative FVPTC group (34.9%) ( p < 0.001). Multivariate analysis showed that absence of BRAF V600E mutation (OR 20.311, p = 0.004) and lymph node metastasis (odds ratio 10.237, p = 0.004) were significantly associated with NIFTP. Conclusion: Although Bethesda category was a statistically significant factor in distinguishing FVPTC subtypes, it was not effective in conclusively distinguishing NIFTP and invasive EFVPTC. Absence of BRAF V600E mutation and lymph node metastasis are important features in distinguishing NIFTP from other subtypes.

Predictive Factors of Lymph Node Metastasis in Follicular Variant of Papillary Thyroid Carcinoma

2017 ◽  
Vol 24 (9) ◽  
pp. 2617-2623 ◽  
Author(s):  
Seo Ki Kim ◽  
Ah-Young Kwon ◽  
Kyorim Back ◽  
Inhye Park ◽  
Nayoon Hur ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Predictive Factors ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Node Metastasis
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