scholarly journals Genetic factors underlying basal cell carcinoma risk: a narrative review

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Sitong Ju ◽  
Wanlin Fan ◽  
Alexander C. Rokohl ◽  
Yongwei Guo ◽  
Vinodh Kakkassery ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Genetic Factors ◽  
Narrative Review ◽  
Carcinoma Risk

Abstract A50: Impact of indoor tanning and MC1R genotype on basal cell carcinoma risk in young people

2015 ◽  
Author(s):  
Annette M. Molinaro ◽  
Leah M. Ferrucci ◽  
Brenda Cartmel ◽  
Erikka Loftfield ◽  
David J. Leffell ◽  
...  
Keyword(s):  
Young People ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Indoor Tanning ◽  
Carcinoma Risk

scholarly journals Basal Cell Carcinoma Risk and TP53 Arg72Pro Polymorphism: An Algerian Population Study

2018 ◽  
Vol 11 (4) ◽  
Author(s):  
Rym Abderrahmane ◽  
Khedidja Benseddik ◽  
Lotfi Louhibi ◽  
Fatima Zohra Moghtit ◽  
Amina Boubekeur ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Population Study ◽  
Basal Cell ◽  
Tp53 Arg72pro ◽  
Algerian Population ◽  
Tp53 Arg72pro Polymorphism ◽  
Carcinoma Risk

Genetic factors determining cutaneous basal cell carcinoma phenotype

2001 ◽  
Vol 36 (5) ◽  
pp. 559-563 ◽  
Author(s):  
Sudarshan Ramachandran ◽  
Anthony A. Fryer ◽  
Richard C. Strange
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Genetic Factors

scholarly journals Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
A. Bauer ◽  
◽  
E. Haufe ◽  
L. Heinrich ◽  
A. Seidler ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Population Based ◽  
Uv Exposure ◽  
Tumor Localization ◽  
Histological Subtype ◽  
Risk Estimates ◽  
Solar Uv ◽  
Carcinoma Risk

Abstract Background A two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed to high solar UV radiation compared to controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the risk estimates. Objectives To evaluate the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure. Methods Six hundred forty-three participants suffering from incident basal cell carcinoma in commonly sun-exposed anatomic sites (capillitium, face, lip, neck, dorsum of the hands, forearms outside, décolleté) of a population-based, case-control, multicenter study performed from 2013 to 2015 in Germany were matched to controls without skin cancer. Multivariate logistic regression analysis was conducted stratified for histological subtype, phototype 1/2 and 3/4. Dose-response curves adjusted for age, age2, sex, phototype and non-occupational UV exposure were calculated. Results Participants with high versus no (OR 2.08; 95% CI 1.24–3.50; p = 0.006) or versus moderate (OR 2.05; 95% CI 1.15–3.65; p = 0.015) occupational UV exposure showed a more than two-fold significantly increased risk to develop BCC in commonly UV-exposed body sites. Multivariate regression analysis did not show an influence of phototype or histological subtype on risk estimates. The restriction of the analysis to BCC cases in commonly sun-exposed body sites did not influence the risk estimates. The occupational UV dosage leading to a 2-fold increased basal cell carcinoma risk was 6126 standard erythema doses. Conclusion The risk to develop basal cell carcinoma in highly occupationally UV-exposed skin was doubled consistently, independent of histological subtype, tumor localization and Fitzpatrick phototype.

scholarly journals Basal cell carcinoma – risk factors and therapeutic strategy

Medic ro ◽  
2021 ◽  
Vol 1 (139) ◽  
pp. 14
Author(s):  
Raluca Maria Moraru ◽  
Dan Mihail Stana ◽  
Corina Popoviciu ◽  
Liviu Moraru
Keyword(s):  
Risk Factors ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Therapeutic Strategy ◽  
Carcinoma Risk

scholarly journals Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Mark P. Little ◽  
Martha S. Linet ◽  
Michael G. Kimlin ◽  
Terrence Lee ◽  
Zaria Tatalovich ◽  
...  
Keyword(s):  
Relative Risk ◽  
Basal Cell Carcinoma ◽  
Ultraviolet Radiation ◽  
Radiation Exposure ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Exposure Response ◽  
Ultraviolet Radiation Exposure ◽  
Carcinoma Risk ◽  
Daily Total

Abstract Background Basal cell carcinoma of the skin (BCC) is the most common cancer in populations of European ancestry. Although consistently linked with basal cell carcinoma of the skin in case-control studies, few prospective cohort studies have evaluated the shape of the exposure-response of basal cell carcinoma associated with cumulative radiant solar ultraviolet exposure (UVR). Methods We followed 63,912 white cancer-free US radiologic technologists from entry (1983–1998) to exit (2003–2005) with known ultraviolet irradiance at up to 5 residential locations. Using generalized-additive and relative risk models we analyzed the exposure-response of basal cell carcinomas associated with ambient cumulative ultraviolet radiant exposure using ground-based National Solar Radiation database Average Daily Total Global data and satellite-based National Aeronautics and Space Administration Total Ozone Mapping Spectrometer data. Results There were 2151 technologists with an incident primary basal cell carcinoma. Risk of basal cell carcinoma rose with increasing cumulative ultraviolet radiation exposure using both measures, such that 1 MJ cm− 2 increased basal cell carcinoma risk by 8.48 (95% CI 5.22, 11.09, p < 0.001) and by 10.15 (95% CI 6.67, 13.10, p < 0.001) per 10,000 persons per year using the Average Daily Total Global and Total Ozone Mapping Spectrometer ultraviolet data, respectively; relative risk was likewise elevated. There was some evidence of upward curvature in the cumulative ultraviolet exposure response using both exposure measures with a greater increase in risk of basal cell carcinoma at higher levels of ultraviolet radiation exposure, but less evidence for curvature in relative risk. There are indications of substantial variation of relative risk with time after exposure and age at exposure, so that risk is highest for the period 10–14 years after ultraviolet radiation exposure and for those exposed under the age of 25. Conclusions We observed increases in risk of basal cell carcinoma and a similar exposure-response for ground-based and satellite ultraviolet radiation measures. Our observations suggest that interventions should concentrate on persons with higher levels of ultraviolet radiation exposure.

scholarly journals Indoor Tanning and the MC1R Genotype: Risk Prediction for Basal Cell Carcinoma Risk in Young People

2015 ◽  
Vol 181 (11) ◽  
pp. 908-916 ◽  
Author(s):  
A. M. Molinaro ◽  
L. M. Ferrucci ◽  
B. Cartmel ◽  
E. Loftfield ◽  
D. J. Leffell ◽  
...  
Keyword(s):  
Young People ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Risk Prediction ◽  
Basal Cell ◽  
Indoor Tanning ◽  
Carcinoma Risk
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