scholarly journals Inhibition of ERK or Akt ameliorates intimal hyperplasia via up-regulation of Cx37 and down-regulation of Cx43 in balloon injury rat model

2020 ◽  
Vol 10 (4) ◽  
pp. 658-666
Author(s):  
Lemen Pan ◽  
Haizhen Ni ◽  
Wenxu Jin ◽  
Xiang Su
Keyword(s):  
Rat Model ◽  
Intimal Hyperplasia ◽  
Balloon Injury ◽  
Down Regulation

scholarly journals Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury

Gene Therapy ◽  
2006 ◽  
Vol 14 (5) ◽  
pp. 396-404 ◽  
Author(s):  
R Cooney ◽  
S O Hynes ◽  
F Sharif ◽  
L Howard ◽  
T O'Brien
Keyword(s):  
Gene Delivery ◽  
Intimal Hyperplasia ◽  
Balloon Injury ◽  
Endothelial Regeneration ◽  
Nos Isoforms

Hippocampal DHCR24 down regulation in a rat model of streptozotocin-induced cognitive decline

2015 ◽  
Vol 587 ◽  
pp. 107-112 ◽  
Author(s):  
Soheila Hosseinzadeh ◽  
Maryam Zahmatkesh ◽  
Mansour Heidari ◽  
Gholam-Reza Hassanzadeh ◽  
Morteza Karimian ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Rat Model ◽  
Down Regulation

Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers

2016 ◽  
Vol 37 (9) ◽  
pp. 522-532 ◽  
Author(s):  
Shoji Kawauchi ◽  
Tsutomu Nakamura ◽  
Sayo Horibe ◽  
Toshihito Tanahashi ◽  
Shigeto Mizuno ◽  
...  
Keyword(s):  
Rat Model ◽  
Down Regulation ◽  
Small Intestinal ◽  
Intestinal Ulcers

scholarly journals Ovariectomy and augmentation of intimal hyperplasia after balloon injury of the rat carotid artery

2000 ◽  
Vol 82 ◽  
pp. 191
Author(s):  
Tomoko Ishibashi ◽  
Satoshi Obayashi ◽  
Takeshi Aso ◽  
Hiroshi Azuma
Keyword(s):  
Carotid Artery ◽  
Intimal Hyperplasia ◽  
Balloon Injury

Function and role of voltage-gated sodium channel NaV1.7 expressed in aortic smooth muscle cells

2009 ◽  
Vol 296 (1) ◽  
pp. H211-H219 ◽  
Author(s):  
Kentaro Meguro ◽  
Haruko Iida ◽  
Haruhito Takano ◽  
Toshihiro Morita ◽  
Masataka Sata ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Smooth Muscle Cells ◽  
Intimal Hyperplasia ◽  
Muscle Cells ◽  
Rt Pcr ◽  
Balloon Injury ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Voltage Gated

Voltage-gated Na+ channel currents ( INa) are expressed in several types of smooth muscle cells. The purpose of this study was to evaluate the expression of INa, its functional role, pathophysiology in cultured human (hASMCs) and rabbit aortic smooth muscle cells (rASMCs), and its association with vascular intimal hyperplasia. In whole cell voltage clamp, INa was observed at potential positive to −40 mV, was blocked by tetrodotoxin (TTX), and replacing extracellular Na+ with N-methyl-d-glucamine in cultured hASMCs. In contrast to native aorta, cultured hASMCs strongly expressed SCN9A encoding NaV1.7, as determined by quantitative RT-PCR. INa was abolished by the treatment with SCN9A small-interfering (si)RNA ( P < 0.01). TTX and SCN9A siRNA significantly inhibited cell migration ( P < 0.01, respectively) and horseradish peroxidase uptake ( P < 0.01, respectively). TTX also significantly reduced the secretion of matrix metalloproteinase-2 6 and 12 h after the treatment ( P < 0.01 and P < 0.05, respectively). However, neither TTX nor siRNA had any effect on cell proliferation. L-type Ca2+ channel current was recorded, and INa was not observed in freshly isolated rASMCs, whereas TTX-sensitive INa was recorded in cultured rASMCs. Quantitative RT-PCR and immunostaining for NaV1.7 revealed the prominent expression of SCN9A in cultured rASMCs and aorta 48 h after balloon injury but not in native aorta. In conclusion, these studies show that INa is expressed in cultured and diseased conditions but not in normal aorta. The NaV1.7 plays an important role in cell migration, endocytosis, and secretion. NaV1.7 is also expressed in aorta after balloon injury, suggesting a potential role for NaV1.7 in the progression of intimal hyperplasia.

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