scholarly journals miR-486 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells

2018 ◽  
Vol 6 (11) ◽  
pp. 209-209 ◽  
Author(s):  
Jin Li ◽  
Qiulian Zhou ◽  
Yajun Liang ◽  
Wen Pan ◽  
Yihua Bei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
A549 Cells ◽  
Alveolar Epithelial ◽  
Induced Apoptosis ◽  
And Oxidative Stress

SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells

2018 ◽  
Vol 496 (4) ◽  
pp. 1291-1295 ◽  
Author(s):  
Jin Li ◽  
Qiulian Zhou ◽  
Tingting Yang ◽  
Yongqin Li ◽  
Yuhui Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Alveolar Epithelial ◽  
Induced Apoptosis ◽  
And Oxidative Stress

scholarly journals Evaluation of the Cytotoxicity and Oxidative Stress Response of CeO2-RGO Nanocomposites in Human Lung Epithelial A549 Cells

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1709 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M. A. Majeed Khan ◽  
ZabnAllah M. Alaizeri ◽  
Hisham A. Alhadlaq
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Human Lung ◽  
Reactive Oxygen Species Generation ◽  
A549 Cells ◽  
Oxidative Stress Response ◽  
Ceo2 Nanoparticles ◽  
Widespread Application ◽  
Lung Epithelial ◽  
And Oxidative Stress

Graphene-based nanocomposites have attracted enormous interest in nanomedicine and environmental remediation, owing to their unique characteristics. The increased production and widespread application of these nanocomposites might raise concern about their adverse health effects. In this study, for the first time, we examine the cytotoxicity and oxidative stress response of a relatively new nanocomposite of cerium oxide-reduced graphene oxide (CeO2-RGO) in human lung epithelial (A549) cells. CeO2-RGO nanocomposites and RGO were prepared by a simple hydrothermal method and characterized by relevant analytical techniques. Cytotoxicity data have shown that RGO significantly induces toxicity in A549 cells, evident by cell viability reduction, membrane damage, cell cycle arrest, and mitochondrial membrane potential loss. However, CeO2-RGO nanocomposites did not cause statistically significant toxicity as compared to a control. We further observed that RGO significantly induces reactive oxygen species generation and reduces glutathione levels. However, CeO2-RGO nanocomposites did not induce oxidative stress in A549 cells. Interestingly, we observed that CeO2 nanoparticles (NPs) alone significantly increase glutathione (GSH) levels in A549 cells as compared to a control. The GSH replenishing potential of CeO2 nanoparticles could be one of the possible reasons for the biocompatible nature of CeO2-RGO nanocomposites. Our data warrant further and more advanced research to explore the biocompatibility/safety mechanisms of CeO2-RGO nanocomposites in different cell lines and animal models.

Oxidative stress induced apoptosis of human lung carcinoma (A549) cells by a novel copper nanorod formulation

2011 ◽  
Vol 49 (11) ◽  
pp. 2990-2996 ◽  
Author(s):  
Menaka C. Thounaojam ◽  
Ravirajsinh N. Jadeja ◽  
Mayur Valodkar ◽  
Padamanabhi S. Nagar ◽  
Ranjitsinh V. Devkar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Carcinoma ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Carcinoma ◽  
Induced Apoptosis

A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference

2010 ◽  
Vol 24 (1) ◽  
pp. 310-318 ◽  
Author(s):  
William E. Wixted ◽  
Chris Kitson ◽  
Jayne C. Colebrook ◽  
Emma J. Roberts ◽  
Steven M. Fox ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rna Interference ◽  
Epithelial Cells ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Novel Targets ◽  
Induced Apoptosis ◽  
Human Lung Epithelial Cells
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