Oxidative stress induced apoptosis of human lung carcinoma (A549) cells by a novel copper nanorod formulation

2011 ◽  
Vol 49 (11) ◽  
pp. 2990-2996 ◽  
Author(s):  
Menaka C. Thounaojam ◽  
Ravirajsinh N. Jadeja ◽  
Mayur Valodkar ◽  
Padamanabhi S. Nagar ◽  
Ranjitsinh V. Devkar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Carcinoma ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Carcinoma ◽  
Induced Apoptosis

Lithium enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells

BioMetals ◽  
2013 ◽  
Vol 26 (2) ◽  
pp. 241-254 ◽  
Author(s):  
Yan Lan ◽  
Xiufeng Liu ◽  
Rong Zhang ◽  
Kai Wang ◽  
Yao Wang ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Carcinoma ◽  
Induced Apoptosis

scholarly journals Barium Titanate (BaTiO3) Nanoparticles Exert Cytotoxicity through Oxidative Stress in Human Lung Carcinoma (A549) Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2309
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M.A. Majeed Khan ◽  
Hisham A. Alhadlaq ◽  
Aws Alshamsan
Keyword(s):  
Oxidative Stress ◽  
Barium Titanate ◽  
Lung Carcinoma ◽  
Human Lung ◽  
A549 Cells ◽  
Lung Fibroblasts ◽  
Dependent Manner ◽  
Zno Nps ◽  
Human Lung Carcinoma ◽  
Batio3 Nanoparticles

Barium titanate (BaTiO3) nanoparticles (BT NPs) have shown exceptional characteristics such as high dielectric constant and suitable ferro-, piezo-, and pyro-electric properties. Thus, BT NPs have shown potential to be applied in various fields including electro-optical devices and biomedicine. However, very limited knowledge is available on the interaction of BT NPs with human cells. This work was planned to study the interaction of BT NPs with human lung carcinoma (A549) cells. Results showed that BT NPs decreased cell viability in a dose- and time-dependent manner. Depletion of mitochondrial membrane potential and induction of caspase-3 and -9 enzyme activity were also observed following BT NP exposure. BT NPs further induced oxidative stress indicated by induction of pro-oxidants (reactive oxygen species and hydrogen peroxide) and reduction of antioxidants (glutathione and several antioxidant enzymes). Moreover, BT NP-induced cytotoxicity and oxidative stress were effectively abrogated by N-acetyl-cysteine (an ROS scavenger), suggesting that BT NP-induced cytotoxicity was mediated through oxidative stress. Intriguingly, the underlying mechanism of cytotoxicity of BT NPs was similar to the mode of action of ZnO NPs. At the end, we found that BT NPs did not affect the non-cancerous human lung fibroblasts (IMR-90). Altogether, BT NPs selectively induced cytotoxicity in A549 cells via oxidative stress. This work warrants further research on selective cytotoxicity mechanisms of BT NPs in different types of cancer cells and their normal counterparts.

scholarly journals 5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhao-Hui Xie ◽  
Mei-Fang Quan ◽  
Fei Liu ◽  
Jian-Guo Cao ◽  
Jian-Song Zhang
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Carcinoma ◽  
Induced Apoptosis

Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production

2018 ◽  
Vol 392 (4) ◽  
pp. 427-436 ◽  
Author(s):  
Louis W. C. Chow ◽  
Ka-Shun Cheng ◽  
Fai Leong ◽  
Chi-Wai Cheung ◽  
Lian-Ru Shiao ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
A549 Cells ◽  
Atp Production ◽  
Human Lung Carcinoma
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