scholarly journals A critical evaluation of quality of life in clinical trials of breast cancer patients treated with radiation therapy

2017 ◽  
Vol 6 (S2) ◽  
pp. S223-S232 ◽  
Author(s):  
Gustavo N. Marta ◽  
Fabio Y. Moraes ◽  
Elton T. T. Leite ◽  
Edward Chow ◽  
David Cella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Critical Evaluation ◽  
Breast Cancer Patients

scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2017 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Mylin A. Torres
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Breast Cancer Patients ◽  
Sf 36 ◽  
A Prospective Study

Abstract Purpose: The purpose of this study was to examine the impact of radiation therapy on quality of life (QOL) of breast cancer patients during and until 1 year after radiation therapy treatment. Methods and materials: Thirty-nine breast cancer patients treated with breast-conserving surgery were enrolled in a prospective study before whole breast radiation therapy (50 Gy plus a 10-Gy boost). No patient received chemotherapy. Data were collected before, at week 6 of radiation therapy, and 6 weeks and 1 year after radiation therapy. The primary outcome variable was quality of life (QOL), measured by Medical Outcomes Study 36-Item Short Form Version 2 (SF-36). Risk factors potentially associated with total SF-36 scores and its physical and mental health component summary scores were also examined, including age, race, marital status, smoking history, menopausal status, endocrine treatment, cancer stage, sleep abnormalities (assessed by the Pittsburgh Sleep Quality Index), and perceived stress levels (assessed by the Perceived Stress Scale). Mixed effect modeling was used to observe QOL changes during and after radiation therapy. Results: Total SF-36 scores did not change significantly during and up to 1 year after radiation therapy compared with baseline measures. Nevertheless, increased body mass index (BMI) and increased perceived stress were predictive of reduced total SF-36 scores over time (P Z .0064, and P < .0001, respectively). In addition, increased BMI was predictive of reduced physical component summary scores of the SF-36 (P Z .0011), whereas increased perceived stress was predictive of worse mental component summary scores (P < .0001). Other proposed potential risk factors including skin toxicity from radiation therapy were not significant. Conclusions: Radiation therapy did not worsen QOL in breast cancer patients. However, preradiation therapy patient characteristics including BMI and perceived stress may be used to identify women who may experience decreased physical and mental function during and up to 1 year after radiation therapy. Copyright 2016 the Authors. Published by EJCS on behalf of Uptodate In Medicine LLC Health Sciences Publishing. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

Depression in women breast cancer patients receiving radiation therapy: A pilot study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12546-e12546
Author(s):  
Fang Chen ◽  
Hao Yu ◽  
Caining Zhao ◽  
Fan Zhang ◽  
Yaqing Nong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Menopausal Status ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
N Stage

e12546 Background: The purpose of this study is to study depression and its risk factors at baseline and explore the changes of depression status during the course of radiation therapy in breast patients. Methods: This is part of a prospective study of treatment toxicity and quality of life. Breast cancer patients, aged 18-year old and above requiring adjuvant radiation therapy were eligible. The primary endpoint depression was assessed by a self-addressed “depression” questionnaires according to NCI “PROMIS”. The Questionnaires were completed one day prior to, during and at the end of treatment. Patient, tumor and prior treatment factors were collected. Cancer specific symptoms were collected by treating physicians and graded according to NIH/NCI CTCAE v4.0. The variables of our interest included age, menopausal status, N-stage,pathology stage, immunohistochemisty, surgical approaches,margin,prior treatments and radiation models. Data are presented as mean (95% confidence interval) unless otherwise specified. Statistical significances were tested using generalized linear model, pearson correlation and t-text. Ps less than 0.05 were considered to be significant. Results: Between July 2019 and January 2020, a total of 185 patients enrolled and completed the PROMIS questionaires. Before RT commencement, 50/185 (27.0%) had some levels of depressive feeling including 40/185 (21.6%), 10/185 (5.4%), and 0/185 (0%) patients for “rarely” (score = 5-8), “sometimes” (score = 9-12), “often” (score = 13-16), and “always” (score 17-20), respectively. Interestingly, N stage and pathology staging group were significantly associated with the depression at baseline while age, menopausal status, immunohistochemistry, previous chemo cycles, chemo regimens and anti-Her2 taget therapy were not. At the end of RT, 51/149 (34.2%) patients had depression level changed, though the absolute lumped scores of depression did not change significantly (p = 0.437). Changes in depression during were significantly associated with menopausal status (p = 0.015) while grade 2 and above toxicities were not (p = 0.421). Conclusions: Depression feeling is not uncommon in breast patients receiving adjuvant radiation. Future study may identify patients with depression and associated risk factors so that proper intervention may be applied to improve long-term survival and quality of life in patients.

“QUALITY OF LIFE ASSESSMENT AT VARIOUS STAGES OF TREATMENT OF BREAST CANCER PATIENTS IN INDIAN DEMOGRAPHICS”

2021 ◽  
pp. 66-68
Author(s):  
Shivakumari Devi ◽  
Uday Pratap Shahi ◽  
Purnima Awasthi ◽  
Ganeshkumar Patel
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Coming Out ◽  
Well Being ◽  
Demographic Characteristics ◽  
Sexual Life ◽  
Breast Cancer Patients

AIM: - The aim of this study is to assess the QOL in breast cancer patients during different stages, mastectomy surgery, chemotherapy, radiation therapy. To evaluate quality of life of females after mastectomy and factors affecting the same in various domain of life MATERIAL AND METHOD:-60 breast cancer patients (mastectomy=20, chemotherapy=20, radiotherapy=20) from May 2019 to Nov 2020. Translated version of a customized questionnaire based on the Royal College of surgeons, quality of life Instrument- Breast cancer patient version (QOL-BC), self-designed questionnaire. Questionnaire is used assess quality of life these patients. Prospective study after whole breast radiation therapy (50Gy plus a 10Gy boost). Patient data collected before beginning of cancer treatment, and at every stage of treatment surgery, chemo and radiation and 3 months after complete treatment. During the interview, we collected information on demographic characteristics, treatment method for breast cancer patient's mastectomy, chemotherapy, and radiotherapy social well-being and quality of life chemotherapy & radiotherapy patients. Statistical analysis performed for the demographic characteristics of social well-being quality of life of mastectomy, chemo therapy and radiotherapy status were summarized using frequency and percentage for categorical variables, means and standard deviation (SD) for continuous variables. Analysis of variance (ANOVA) was used to compare mean of the total QOL scores in three study groups. Data analyses was done using SPSS version 16.0 software. RESULT:- For mastectomy surgery body image, pain, activity daily living, treatment, the mean QOL score coming out to be above the 50 percent of total QOL score, psychological aspect almost 50 percent score and sexual life less than 50 percent score .QOL chemotherapy total score coming out almost 50 percent and radiotherapy less than 50 percent score. CONCLUSION: Adequate social support from family members, friends and neighbors, and higher scores of social well-beings, were associated with signicantly improved quality of life Breast cancer patients.

scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2016 ◽  
Vol 1 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Jennifer Felger ◽  
Donna Mister ◽  
Tian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Radiation Therapy ◽  
Prospective Study ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
A Prospective Study

scholarly journals Patient-reported cosmetic satisfaction and the long-term association with quality of life in irradiated breast cancer patients

2019 ◽  
Vol 179 (2) ◽  
pp. 479-489
Author(s):  
M. C. T. Batenburg ◽  
◽  
M. L. Gregorowitsch ◽  
W. Maarse ◽  
A. Witkamp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Radiation Therapy ◽  
Social Functioning ◽  
Cancer Patients ◽  
Cosmetic Outcome ◽  
Breast Cancer Patients ◽  
Patient Reported ◽  
The Difference

Abstract Purpose To evaluate patient-reported cosmetic satisfaction in women treated with radiation therapy for breast cancer and to determine the association between dissatisfaction and quality of life (QoL) and depression. Methods Within the prospective UMBRELLA breast cancer cohort, all patients ≥ 1 year after breast conserving treatment or mastectomy with immediate reconstruction were selected. Self-reported cosmetic satisfaction was measured on a 5-point Likert scale. QoL, social functioning, and emotional functioning were measured using EORTC QLQ-C30 and BR23 at 1, 2, and 3 years after inclusion. Mixed model analysis was performed to assess the difference in different domains of QoL between patients with good versus poor self-reported cosmetic satisfaction over time after adjustment for potential confounders. Depression scores were collected by means of the HADS-NL questionnaire. Chi-square test or Fisher's exact test was used to assess the difference in proportions of HADS score ≥ 8, indicating increased depression risk, between satisfied and dissatisfied patients. Results 808 patients were selected for analysis. Respectively one, two, and three years after surgery, 8% (63/808), 7% (45/626), and 8% (31/409) of patients were dissatisfied with their cosmetic outcome. Poor patient-reported cosmetic satisfaction was independently associated with impaired QoL, body image, and lower emotional and social functioning. Scores ≥ 8 on the HADS depression subscale were significantly more common in dissatisfied patients. Conclusions Dissatisfaction with cosmetic outcome was low after breast cancer surgery followed by radiation therapy during 3 years follow-up. Knowing the association between dissatisfaction with cosmetic outcome and QoL and depression could help to improve the preoperative counseling of breast cancer patients.

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