scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2016 ◽  
Vol 1 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Jennifer Felger ◽  
Donna Mister ◽  
Tian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Radiation Therapy ◽  
Prospective Study ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
A Prospective Study

Quality of life and patient satisfaction in breast cancer patients after immediate breast reconstruction: a prospective study

The Breast ◽  
2005 ◽  
Vol 14 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Elisabeth Edström Elder ◽  
Yvonne Brandberg ◽  
Tina Björklund ◽  
Richard Rylander ◽  
Jakob Lagergren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Patient Satisfaction ◽  
Breast Reconstruction ◽  
Prospective Study ◽  
Cancer Patients ◽  
Immediate Breast Reconstruction ◽  
Breast Cancer Patients ◽  
A Prospective Study

scholarly journals A prospective study of quality of life in breast cancer patients undergoing radiation therapy

2017 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Canhua Xiao ◽  
Andrew H. Miller ◽  
Mylin A. Torres
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Breast Cancer Patients ◽  
Sf 36 ◽  
A Prospective Study

Abstract Purpose: The purpose of this study was to examine the impact of radiation therapy on quality of life (QOL) of breast cancer patients during and until 1 year after radiation therapy treatment. Methods and materials: Thirty-nine breast cancer patients treated with breast-conserving surgery were enrolled in a prospective study before whole breast radiation therapy (50 Gy plus a 10-Gy boost). No patient received chemotherapy. Data were collected before, at week 6 of radiation therapy, and 6 weeks and 1 year after radiation therapy. The primary outcome variable was quality of life (QOL), measured by Medical Outcomes Study 36-Item Short Form Version 2 (SF-36). Risk factors potentially associated with total SF-36 scores and its physical and mental health component summary scores were also examined, including age, race, marital status, smoking history, menopausal status, endocrine treatment, cancer stage, sleep abnormalities (assessed by the Pittsburgh Sleep Quality Index), and perceived stress levels (assessed by the Perceived Stress Scale). Mixed effect modeling was used to observe QOL changes during and after radiation therapy. Results: Total SF-36 scores did not change significantly during and up to 1 year after radiation therapy compared with baseline measures. Nevertheless, increased body mass index (BMI) and increased perceived stress were predictive of reduced total SF-36 scores over time (P Z .0064, and P < .0001, respectively). In addition, increased BMI was predictive of reduced physical component summary scores of the SF-36 (P Z .0011), whereas increased perceived stress was predictive of worse mental component summary scores (P < .0001). Other proposed potential risk factors including skin toxicity from radiation therapy were not significant. Conclusions: Radiation therapy did not worsen QOL in breast cancer patients. However, preradiation therapy patient characteristics including BMI and perceived stress may be used to identify women who may experience decreased physical and mental function during and up to 1 year after radiation therapy. Copyright 2016 the Authors. Published by EJCS on behalf of Uptodate In Medicine LLC Health Sciences Publishing. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

A prospective study on behavioral symptoms’ impact to the quality of life in patients with early-stage cancer receiving radiotherapy.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 46-46
Author(s):  
Canhua Xiao ◽  
Jennifer Felger ◽  
Donna Mister ◽  
Tian Liu ◽  
Andrew H. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Prospective Study ◽  
Cancer Patients ◽  
Early Stage ◽  
Behavioral Symptoms ◽  
Breast Cancer Patients ◽  
A Prospective Study ◽  
Over Time

46 Background: Fatigue, sleep problems, and depression are the most common behavioral symptoms experienced by breast cancer patients. The purpose of this study was to examine these behavioral symptoms’ impact on quality of life (QOL) for early stage breast cancer patients receiving radiotherapy (RT). Methods: This was a prospective study of 46 patients receiving whole breast RT (50 Gy plus a 10 Gy boost) following lumpectomy. Data were collected at pre-RT, week 6 of RT, and 6-weeks post-RT. QOL was measured by Short Form-36, fatigue by Multidimensional Fatigue Inventory, sleep by Pittsburgh Sleep Quality Index, depression by Inventory for Depressive Symptomatology-Self-Rated, and stress by Perceived Stress Scale. No patients were treated with chemotherapy. Demographic/clinical variables, including age, race, marriage, smoking history, hormone treatment, and cancer stage, were collected at the time of enrollment. Mixed effect modeling was utilized to observe behavioral symptoms’ impact on QOL over time. Results: Fatigue and depression, along with stress, had significant impact on QOL after controlling for body mass index (BMI; the only one significant demographic/clinical variable; see Table). Patients with more fatigue, depression, or stress were more likely to have worse QOL during and post-RT. Patients having a higher BMI at baseline also reported worse QOL over time. Sleep was significantly correlated with QOL in univariate analyses, while this effect disappeared in multivariate models. Conclusions: Behavioral symptoms, in particular fatigue and depression, along with stress, have significant impact on the QOL of early breast cancer patients’ receiving RT. Future research on the underlying biological mechanisms will improve our understanding of these symptoms and their relationships, which will help to find potential targets for multiple related symptoms and, ultimately, improve patients’ QOL. [Table: see text]

Depression in women breast cancer patients receiving radiation therapy: A pilot study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12546-e12546
Author(s):  
Fang Chen ◽  
Hao Yu ◽  
Caining Zhao ◽  
Fan Zhang ◽  
Yaqing Nong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Risk Factors ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Menopausal Status ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
N Stage

e12546 Background: The purpose of this study is to study depression and its risk factors at baseline and explore the changes of depression status during the course of radiation therapy in breast patients. Methods: This is part of a prospective study of treatment toxicity and quality of life. Breast cancer patients, aged 18-year old and above requiring adjuvant radiation therapy were eligible. The primary endpoint depression was assessed by a self-addressed “depression” questionnaires according to NCI “PROMIS”. The Questionnaires were completed one day prior to, during and at the end of treatment. Patient, tumor and prior treatment factors were collected. Cancer specific symptoms were collected by treating physicians and graded according to NIH/NCI CTCAE v4.0. The variables of our interest included age, menopausal status, N-stage,pathology stage, immunohistochemisty, surgical approaches,margin,prior treatments and radiation models. Data are presented as mean (95% confidence interval) unless otherwise specified. Statistical significances were tested using generalized linear model, pearson correlation and t-text. Ps less than 0.05 were considered to be significant. Results: Between July 2019 and January 2020, a total of 185 patients enrolled and completed the PROMIS questionaires. Before RT commencement, 50/185 (27.0%) had some levels of depressive feeling including 40/185 (21.6%), 10/185 (5.4%), and 0/185 (0%) patients for “rarely” (score = 5-8), “sometimes” (score = 9-12), “often” (score = 13-16), and “always” (score 17-20), respectively. Interestingly, N stage and pathology staging group were significantly associated with the depression at baseline while age, menopausal status, immunohistochemistry, previous chemo cycles, chemo regimens and anti-Her2 taget therapy were not. At the end of RT, 51/149 (34.2%) patients had depression level changed, though the absolute lumped scores of depression did not change significantly (p = 0.437). Changes in depression during were significantly associated with menopausal status (p = 0.015) while grade 2 and above toxicities were not (p = 0.421). Conclusions: Depression feeling is not uncommon in breast patients receiving adjuvant radiation. Future study may identify patients with depression and associated risk factors so that proper intervention may be applied to improve long-term survival and quality of life in patients.

scholarly journals Erratum, Axilla Surgery Severely Affects Quality of Life: Results of a 5-year Prospective Study in Breast Cancer Patients

2003 ◽  
Vol 80 (2) ◽  
pp. 233-233 ◽  
Author(s):  
Jutta Engel ◽  
Jacqueline Kerr ◽  
Anne Schlesinger-Raab ◽  
Hansjörg Sauer ◽  
Dieter Hölzel
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Prospective Study ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Axilla Surgery
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