The criteria of the identification of metabolic obesity among people with normal body weight and their use in everyday practice

2018 ◽  
Vol 87 (1) ◽  
pp. 34-39
Author(s):  
Katarzyna Pastusiak ◽  
Juliusz Przysławski
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Weight ◽  
Historical Perspective ◽  
Normal Body Mass Index ◽  
Health Issues ◽  
Normal Body ◽  
The Metabolic Syndrome ◽  
Normal Body Weight ◽  
Clinic Practice

Obesity and the metabolic syndrome caused by it constitute one of the biggest health issues of the 21st century. However, a problem of “a concealed form of obesity” — metabolic obesity with a normal body weight, which manifests clinically through the occurrence of metabolism disorders related to obesity among people with a normal body mass index — was pointed out in the 1980s. This affliction entails similar health consequences and causes many more problems in diagnosis and early treatment because a lack of obesity does not make doctors search for the traits of metabolic syndrome among seemingly healthy patients. The aim of this study is to present a proposition of diagnostic criteria for this disease in the historical perspective and to consider the possibilities of their use in everyday clinic practice.

scholarly journals TRAUMATIC DISEASE PECULIARITIES COURSE, ITS DIAGNOSTICS AND TREATMENT AT POLYTRAUMA IN SUFFER OBESE PATIENTS

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Obese Patients ◽  
Prognostic Features ◽  
Normal Body ◽  
Significant Difference ◽  
Normal Body Weight

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.

Effects of TNF-α antagonist infliximab on fructose-induced metabolic syndrome in rats

2020 ◽  
pp. 096032712096996
Author(s):  
Yasmine A Abdelhamid ◽  
Mohammed F Elyamany ◽  
Muhammad Y Al-Shorbagy ◽  
Osama A Badary
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Adult Population ◽  
Health Issues ◽  
Serum Triglycerides ◽  
Fructose Intake ◽  
The Metabolic Syndrome ◽  
High Fructose ◽  
Affect Body Weight ◽  
Tnf Α

Public health issues have been raised regarding fructose toxicity and its serious metabolic disorders. Deleterious effects of high fructose intake on insulin sensitivity, body weight, lipid homeostasis have been identified. The new millennium has witnessed the emergence of a modern epidemic, the metabolic syndrome (MS), in approximately 25% of the world’s adult population. The current study aimed to investigate the effect of the TNF-α antagonist infliximab on fructose-induced MS in rats. Rats were administered fructose (10%) in drinking water for 12 weeks to induce the experimental MS model. infliximab (5 mg/kg) was injected once weekly intraperitoneally starting on the 13th week for 4 weeks. Increase in body weight, blood glucose level, serum triglycerides (TGs), adiponectin level and blood pressure were present in MS rats. They also prompted increases in serum of leptin, TNF-α, and malondialdehyde (MDA) levels. Treatment with infliximab did not affect body weight, hyperglycemia or hypertension, but decreased serum TGs and increased serum HDL-c levels. Infliximab also decreased adiponectin levels. Surprisingly, infliximab increased MDA above its value in the MS group. These results reflect the fact that infliximab affects the manifestations of MS in rats. Though infliximab reduced TGs, increased HDL-c levels, reversed adiponectin resistance occurred by fructose, the drug failed to combat MS-mediated hyperglycemia, hypertension, and elevated MDA above the insult.

scholarly journals Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

2020 ◽  
Author(s):  
Anna Socha-Banasiak ◽  
Arkadiusz Michalak ◽  
Krzysztof Pacześ ◽  
Zuzanna Gaj ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Serum Concentrations ◽  
Normal Body ◽  
Normal Body Weight

Abstract Background: Fibroblast growth factor 19 (FGF19), Fibroblast growth factor 21 (FGF21) and Klotho are regulators of energy homeostasis. However, in the paediatric population the relationship between obesity, metabolic disorders and mentioned factors has not been clearly investigated. We analysed serum concentrations of FGF19, FGF21 and Klotho in children and adolescents with normal body weight as well as in overweight and obese subjects – and their associations with components of metabolic syndrome and insulin resistance (IR).Methods: The cross-sectional study conducted in the group of hospitalised children and adolescents. Laboratory investigation included serum ELISA tests for FGF19, FGF21, Klotho as well as lipid profile and oral glucose tolerance test for calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The clinical analysis included blood pressure measurement, body fat percentage estimation and assessing the prevalence of metabolic syndrome (MS) and its components. Results: The study was conducted on 174 children/adolescents aged 6-17 years divided into the following groups: with normal body weight (N=48), with obesity (N=92) and overweight subjects (N=34). Klotho levels were significantly higher in the group of subjects with obesity [median 168.6 pg/ml]) than those with overweight [131.3 pg/ml] and normal body weight [116.6 pg/ml] (p=0.0334). Median serum FGF21 level was elevated in the group of patients with MS in comparison to other subjects [136.2 pg/ml vs 82.6 pg/ml, p=0.0285]. Increased Klotho concentrations were noted in patients affected by IR compared with subjects with normal insulin sensitivity [185.3 pg/ml vs 132.6 pg/ml, p=0.0282]. Multivariable model for HOMA-IR showed FGF19 as an independent predictor for IR after adjusting for the pubertal stage and BMI Z-score.Conclusions: Klotho levels were associated with body weight status in children and adolescents. Moreover, Klotho, FGF19 and FGF21 concentrations correlated with IR status and traits of MS.

IS A NORMAL BODY MASS INDEX PROTECTIVE IN WOMEN WITH METABOLIC SYNDROME AND SUSPECTED MYOCARDIAL ISCHEMIA?

2020 ◽  
Vol 75 (11) ◽  
pp. 2043
Author(s):  
Odayme Quesada ◽  
Janet Wei ◽  
Nissi Suppogu ◽  
Galen Cook-Wiens ◽  
Marie Lauzon ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Myocardial Ischemia ◽  
Body Mass ◽  
Normal Body Mass Index ◽  
Normal Body

scholarly journals Normal body mass index (BMI) can rule out metabolic syndrome

Medicine ◽  
2019 ◽  
Vol 98 (9) ◽  
pp. e14712 ◽  
Author(s):  
Ofer Kobo ◽  
Ronit Leiba ◽  
Ophir Avizohar ◽  
Amir Karban
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Normal Body Mass Index ◽  
Normal Body ◽  
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