scholarly journals Epicardial Adipose Tissue and Metabolic Syndrome in Hypertensive Patients With Normal Body Weight and Waist Circumference

2011 ◽  
Vol 24 (11) ◽  
pp. 1245-1249 ◽  
Author(s):  
S. D. Pierdomenico ◽  
A. M. Pierdomenico ◽  
M. Neri ◽  
F. Cuccurullo
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Adipose Tissue ◽  
Waist Circumference ◽  
Epicardial Adipose Tissue ◽  
Hypertensive Patients ◽  
Normal Body ◽  
Normal Body Weight

Monocyte-associated chemokine expression in cells from subcutaneous adipose tissue isolated from operation material in patients during abdominoplasty

2017 ◽  
pp. 70-78
Author(s):  
А.Е. Копасов ◽  
С.Н. Блохин ◽  
С.Г. Морозов
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Aesthetic Surgery ◽  
Normal Body ◽  
Chemokine Expression ◽  
Normal Body Weight ◽  
Functional Features ◽  
Subcutaneous Adipose ◽  
The Relationship

Цель работы - изучение взаимосвязи между уровнем хемокинов и интенсивностью воспалительного процесса в подкожно-жировой ткани (ПЖТ) у лиц с ожирением и нормальной массой тела. Задача работы - определение уровня экспрессии хемокинов, сопряженных с моноцитами/макрофагами, и их рецепторов в клетках ПЖТ, выделенных при проведении абдоминопластики. Пациенты. В период с 2013 по 2017 гг. в Клинике пластической и эстетической хирургии проведены операции абдоминопластики у 262 женщин, биологический материал которых использован в работе. Методы. Состав тела и процент жировой массы определяли методом биоимпедансного анализа. Из образцов ПЖТ из операционного материала выделяли клетки, окрашивали их меченными флуоресцеинами антителами к хемокинам и анализировали на проточном цитометре FACSCalibur по программе SimulSet. Статистический анализ проводили по программе ANOVA. Результаты. Показано, что наличие ожирения оказывает влияние на клеточный состав ПЖТ. Экспрессия хемокинов семейства CC, а также рецепторов хемокинов CCR1, CCR2 и CCR5 в ПЖТ у пациентов с ожирением достоверно выше, чем у пациентов с нормальной массой тела. Заключение. Различия в экспрессии хемокинов на клетках ПЖТ у пациентов с ожирением или с нормальной массой тела отражают функциональные особенности ПЖТ и могут оказывать влияние на развитие осложнений после проведения операции абдоминопластики. AIM: we study the relationship between chemokines and intensity of the inflammatory process in the subcutaneous adipose tissue (SAT) in individuals with obesity and normal body weight. Objective: we determined the expression levels of chemokines associated with monocyte/macrophages, as well as their receptors on the cells of SAT, that were obtained during abdominoplasty. Patients. In this work we have used the biological material of 262 women to whom has been performed an abdominoplasty in the Clinic of plastic and aesthetic surgery from 2013 to 2017 years. Methods. Body composition and the weight of body fat were determined by bioimpedance analysis. SATs have been obtained during abdominoplasty surgery. SAT cells were isolated followed by the staining with fluoresceine labeled antibodies which fluorescence was analyzed using a flow cytometer FACSCalibur according to the program SimulSet. Statistical analysis was carried out using ANOVA. Results. It has been shown that the progressing obesity may affect the SAT cellular composition. The expression of chemokines from CC family and its receptors (CCR1, CCR2 and CCR5) on cells from SAT were significantly higher in patients with obesity compared to the normal body weight patients. Conclusions. Differences in the chemokine expression on SAT cells between patients with obesity and with normal body weight may reflect the functional features of SAT itself and can modify the complication developments after abdominoplasty.

The criteria of the identification of metabolic obesity among people with normal body weight and their use in everyday practice

2018 ◽  
Vol 87 (1) ◽  
pp. 34-39
Author(s):  
Katarzyna Pastusiak ◽  
Juliusz Przysławski
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Weight ◽  
Historical Perspective ◽  
Normal Body Mass Index ◽  
Health Issues ◽  
Normal Body ◽  
The Metabolic Syndrome ◽  
Normal Body Weight ◽  
Clinic Practice

Obesity and the metabolic syndrome caused by it constitute one of the biggest health issues of the 21st century. However, a problem of “a concealed form of obesity” — metabolic obesity with a normal body weight, which manifests clinically through the occurrence of metabolism disorders related to obesity among people with a normal body mass index — was pointed out in the 1980s. This affliction entails similar health consequences and causes many more problems in diagnosis and early treatment because a lack of obesity does not make doctors search for the traits of metabolic syndrome among seemingly healthy patients. The aim of this study is to present a proposition of diagnostic criteria for this disease in the historical perspective and to consider the possibilities of their use in everyday clinic practice.

scholarly journals SAT-612 Features of the Severity of Cardiovascular Remodeling and Metabolic Disorders in Hypertensive Patients with Obesity in the Presence of Two Unfavorable Genotypes of the ADIPOQ and IRS-1 Genes

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anna Shalimova ◽  
Valentyna Psarova ◽  
Nataliia Kyrychenko ◽  
Maryna Kochuieva
Keyword(s):  
Body Weight ◽  
Metabolic Disorders ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Healthy Individuals ◽  
Simultaneous Presence ◽  
Hypertensive Patients ◽  
Cardiovascular Remodeling ◽  
Normal Body ◽  
Normal Body Weight

Abstract The results of a number of studies have shown that in arterial hypertension (AH), G/T and T/T genotypes of the adiponectin gene (ADIPOQ) and Gly/Arg and Arg/Arg genotypes of the insulin receptor substrate 1 gene (IRS-1) are associated with a greater severity of metabolic disorders and hemodynamic parameters compared with G/G and Gly/Gly genotypes of these genes. The aim of the study: to evaluate the severity of cardiovascular remodeling and metabolic disorders in hypertensive obese patients in the simultaneous presence of two unfavorable genotypes of the ADIPOQ and IRS-1 genes. Methods: We examined 300 AH patients: 200 patients with AH and obesity, 50 patients with AH and normal body weight, 50 patients with AH and overweight, 40 patients with AH, obesity and type 2 diabetes mellitus (DM2), 30 healthy individuals. The polymorphisms of the ADIPOQ and IRS-1 was assessed by molecular genetic method. Results: It was found that in all groups of hypertensive patients, regardless of body weight and the presence of DM2, the simultaneous presence of two unfavorable genotypes of the ADIPOQ and IRS-1 genes occurred significantly more often than in healthy individuals: in 41% of AH patients with obesity, 30% of AH patients with normal weight, 40% of AH with overweight, 57.5% of AH with obesity and DM2 vs. 13.3% of healthy individuals. In hypertensive patients, in the presence of overweight and obesity, the frequency of combination of the two unfavorable genotypes of these genes was significantly higher than in AH patients with normal body weight. Conducting comparative evaluation of AH patients with obesity depending on the presence of two unfavorable genotypes or two protective genotypes of the ADIPOQ and IRS-1 genes showed that carriers of the combination of the G/T + T/T genotype of the ADIPOQ and the Gly/Arg + Arg/Arg genotype of the IRS-1 had a higher body mass index, more pronounced insulin resistance, cardiovascular remodeling, adipokine imbalance, impaired carbohydrate and lipid metabolism. Conclusions: In AH patients, the frequency of the simultaneous presence of two unfavorable polymorphisms of ADIPOQ and IRS-1 genes was higher than in healthy individuals. In AH patients with overweight and obesity, the frequency of combination of the two unfavorable genotypes of the ADIPOQ and IRS-1 genes was significantly higher than in normal body weight. The presence of a combination of two unfavorable genotypes of the ADIPOQ and IRS-1 genes in patients with AH and obesity was associated with a greater severity of cardiovascular remodeling and metabolic disorders compared with the combination of two protective genotypes of these genes.

scholarly journals Prevalence of overweight and obesity in professional soldiers of the Czech army over a 11-year period

2016 ◽  
Vol 73 (5) ◽  
pp. 422-428 ◽  
Author(s):  
Jana Fajfrová ◽  
Vladimír Pavlík ◽  
Jan Psutka ◽  
Michaela Husarová ◽  
Pavla Krutisová ◽  
...  
Keyword(s):  
Body Weight ◽  
Waist Circumference ◽  
Biochemical Parameters ◽  
Armed Forces ◽  
Communicable Diseases ◽  
Overweight And Obesity ◽  
Anthropometric Parameters ◽  
Non Communicable Diseases ◽  
Normal Body ◽  
Normal Body Weight

Background/Aim. Obesity is currently considered to be the most frequent metabolic disease worldwide, not only in developed but also in developing countries. The aim of this work was to describe the development of health status in soldiers of the Armed Forces of the Czech Republic (ACR) and to emphasize the markers of non-communicable diseases. Our study describes the anthropometric and biochemical parameters of a large group of Czech Army professional soldiers. Data were obtained over a period of 11 years. Methods. During the monitored period, from 1999 to 2009, military physicians carried out on the average 6,360 examinations on professional soldiers per year and monitored their health and nutritional status with the aim of preventing the risk factors of non-communicable diseases. These examinations are compulsory for all professional soldiers at the age of 25, 30, 33, and 36 years. From the age of 39, these examinations are carried out every year till the end of their career. Besides taking personal histories and carrying out standard physical examinations, blood was taken for biochemical examination. The following anthropometric parameters were monitored: body constitution using body mass index (BMI) and waist circumference. Our study describes only part of the data concerning anthropometric and biochemical parameters of professional soldiers which were obtained over a period of 11 years. Results. Average BMI values in men were in the overweight range (26.5-27 kg/m2). Average values of waist circumference, however, ranged from 91.9 cm to 93.4 cm. Between the first and the last year of monitoring a statistically significant decrease in these values ranging from 93.4 ? 9.8 cm to 92.7 ? 9.5 cm (p < 0.001) was observed. All monitored anthropometric parameters in female professional soldiers were within normal limits. During the monitored period the proportion of overweight men gradually increased from 52% to 57.1% (p < 0.001). There were no statistically significant changes in the prevalence of obesity in men (12-15%). Average glycaemia levels were within normal range in both men and women. A statistically significant decrease in these levels, however, was observed in men (from 5.1 ? 0.9 mmol/L to 4.8 ? 0.7 mmol/L (p < 0.001) and in women (from 4.9 ? 0.6 mmol/L to 4.6 ? 0.6 mmol/L (p < 0.001). Concerning the lipid profile in men, a significant decrease in average values of total cholesterol, triglycerides and LDL cholesterol was observed; from 5.5 ? 1.1 mmol/L to 5.1 ? 1.0 mmol/L (p < 0.001), from 2.0 ? 1.6 mmol/L to 1.6 ? 1.2 mmol/L (p < 0.001) and from 3.4 ? 1.1 mmol/L to 3.2 ? 0.9 mmol/L (p < 0.001), respectively. Conclusion. During the monitored period only one-third of military professionals had normal body weight. More favorable situation was in female professional soldiers, two-thirds of them had normal body weight during the monitored period. Additionally, the increase in the number of individuals with BMI values in the overweight range was observed. Although the number of overweight soldiers was overestimated as a result of the inclusion of individuals with increased body weight due to well-developed musculature, the number of overweight and obese soldiers is still high.

scholarly journals Epicardial adipose tissue as a marker of visceral obesity and its association with metabolic parameters and remodeling of the left chambers of the heart in young people with abdominal obesity

2019 ◽  
Vol 91 (9) ◽  
pp. 68-76
Author(s):  
N V Blinova ◽  
M O Azimova ◽  
Y V Zhernakova ◽  
E A Zheleznova ◽  
E B Yarovaya ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Waist Circumference ◽  
Abdominal Obesity ◽  
Epicardial Adipose Tissue ◽  
Left Ventricular ◽  
The Body ◽  
Metabolic Parameters ◽  
Lv Mass

Aim: to study the correlation of epicardial adipose tissue (EAT) with metabolic parameters, 24-hours profile of blood pressure (BP) and left ventricular remodeling, with the volume of intraabdominal adipose tissue (IAAT), measured by multislice computed tomography (MSCT) in patients with abdominal obesity and metabolic syndrome. Materials and methods: the study included 80 participants with abdominal obesity (waist circumference > 80 cm in women and >94 cm in men) and without cardiovascular diseases and diabetes. Within this study the following examinations were performed: waist circumference and the body mass index measurement, blood sampling and measurements of lipid levels, uric acid, fasting glucose, insulin, HOMA index, 24-hour ambulatory blood pressure monitoring. Left ventricular (LV) mass index, relative wall thickness, LV mass/height index were estimated from echocardiographic data. EAT volume and IAAT was measured by MSCT. All patients was devided in two groups for analysis: 1 (n=28) - patients with isolated abdominal obesity, without metabolic syndrome, age was 37.5±6.43 years; 2 (n=52) - patients with metabolic syndrome, age - 38.8±5.88 years. The control group 0 included healthy individuals (n=13) without obesity, age was 30.5±5.97 years. Results. A positive correlation was found between the volume of EAT with the level of insulin in the blood (r=0.2937, p

scholarly journals Klotho, fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity – and their associations with metabolic parameters.

2020 ◽  
Author(s):  
Anna Socha-Banasiak ◽  
Arkadiusz Michalak ◽  
Krzysztof Pacześ ◽  
Zuzanna Gaj ◽  
Wojciech Fendler ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Serum Concentrations ◽  
Normal Body ◽  
Normal Body Weight

Abstract Background: Fibroblast growth factor 19 (FGF19), Fibroblast growth factor 21 (FGF21) and Klotho are regulators of energy homeostasis. However, in the paediatric population the relationship between obesity, metabolic disorders and mentioned factors has not been clearly investigated. We analysed serum concentrations of FGF19, FGF21 and Klotho in children and adolescents with normal body weight as well as in overweight and obese subjects – and their associations with components of metabolic syndrome and insulin resistance (IR).Methods: The cross-sectional study conducted in the group of hospitalised children and adolescents. Laboratory investigation included serum ELISA tests for FGF19, FGF21, Klotho as well as lipid profile and oral glucose tolerance test for calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. The clinical analysis included blood pressure measurement, body fat percentage estimation and assessing the prevalence of metabolic syndrome (MS) and its components. Results: The study was conducted on 174 children/adolescents aged 6-17 years divided into the following groups: with normal body weight (N=48), with obesity (N=92) and overweight subjects (N=34). Klotho levels were significantly higher in the group of subjects with obesity [median 168.6 pg/ml]) than those with overweight [131.3 pg/ml] and normal body weight [116.6 pg/ml] (p=0.0334). Median serum FGF21 level was elevated in the group of patients with MS in comparison to other subjects [136.2 pg/ml vs 82.6 pg/ml, p=0.0285]. Increased Klotho concentrations were noted in patients affected by IR compared with subjects with normal insulin sensitivity [185.3 pg/ml vs 132.6 pg/ml, p=0.0282]. Multivariable model for HOMA-IR showed FGF19 as an independent predictor for IR after adjusting for the pubertal stage and BMI Z-score.Conclusions: Klotho levels were associated with body weight status in children and adolescents. Moreover, Klotho, FGF19 and FGF21 concentrations correlated with IR status and traits of MS.

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