scholarly journals The role of flow cytometry in celiac disease screening using human leukocyte antigen in adult patients with type 1 diabetes mellitus

2016 ◽  
Author(s):  
Miren Vicuña Arregui
Keyword(s):  
Diabetes Mellitus ◽  
Flow Cytometry ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals A Case of Fulminant Type 1 Diabetes Mellitus with Human Leukocyte Antigen DR4-DQ4

2012 ◽  
Vol 27 (4) ◽  
pp. 314
Author(s):  
Ye-Ri So ◽  
Ja-Won Koo ◽  
Young-Hak Cho ◽  
You-Cheol Hwang ◽  
Kyu-Jeung Ahn ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Fulminant Type 1 Diabetes ◽  
Leukocyte Antigen ◽  
Fulminant Type

Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan

2018 ◽  
Vol 19 (4) ◽  
pp. 699-706
Author(s):  
Yi-Ching Tung ◽  
Cathy S-J Fann ◽  
Chien-Ching Chang ◽  
Chen-Chung Chu ◽  
Wei-Shiung Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Leukocyte Antigen

Human leukocyte antigen-DQA1*0501 allele and its association with pathogenesis of type 1 diabetes mellitus among Iraqi children

Gene Reports ◽  
2019 ◽  
Vol 17 ◽  
pp. 100517
Author(s):  
Amir Fadhil Al-Tu'ma ◽  
Zuhair Mohammed Ali Jeddoa ◽  
Hedef Dhafir El-Yassin ◽  
Dhafer A.F. Al-Koofee
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals Juxtaposition of Coeliac Disease and Type 1 Diabetes; the Role of Shared Non-Human Leukocyte Antigen Loci

2018 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Iraj Shahramian ◽  
Hossein Shahdadi ◽  
Ali Bazi ◽  
Nosratollah Masinaeinejad ◽  
Mojtaba Delaramnasab
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Coeliac Disease ◽  
Adaptor Protein ◽  
Human Leukocyte ◽  
Substantial Impact ◽  
Leukocyte Antigen

Although extensive studies have been performed to explore the role of various alleles within the human leukocyte antigen (HLA) in susceptibility to coeliac disease (CD) and type 1 diabetes (T1D), less attention has been dedicated to the role of shred non-HLA loci. In present report, we have provided a review on the role of genetic variants in seven shared non-HLA loci in determination the risk of either CD or T1D. The literature search was done on the Web of Knowledge, PubMed, and Scopus databases using keywords of polymorphism, coeliac disease, and type 1 diabetes. The literature published within 2000-2017 were recruited. Seven discussed shared loci between CD and T1D were those resided within cytotoxic T-lymphocyte associated protein 4 (CTL4), regulator of G protein signaling (RGS1), SH2B adaptor protein (SH2B3), T cell activation Rho GTPase activating protein (TAGAP), interleukin 18 receptor accessory protein (IL18RAP), protein tyrosine phosphatase, non-receptor type (PTPN2), and C-C motif chemokine receptor (CCR5). Interaction between polymorphisms of these genes seems to exert a substantial impact on determination the risk of CD and T1D in context of each other. Polymorphisms residing in these loci can exert synergistic or opposing effects toward either protection or predisposition to CD and T1D. The majority of these polymorphisms affect the function of cytokine signaling or T cell activating pathways. The net outcome deems to be delineated by a complex interaction between these adaptor arms, as well as the modulatory effects of other components of immune system, in particular HLA alleles.

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