Human leukocyte antigen-DQA1*0501 allele and its association with pathogenesis of type 1 diabetes mellitus among Iraqi children

Gene Reports ◽  
2019 ◽  
Vol 17 ◽  
pp. 100517
Author(s):  
Amir Fadhil Al-Tu'ma ◽  
Zuhair Mohammed Ali Jeddoa ◽  
Hedef Dhafir El-Yassin ◽  
Dhafer A.F. Al-Koofee
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals A Case of Fulminant Type 1 Diabetes Mellitus with Human Leukocyte Antigen DR4-DQ4

2012 ◽  
Vol 27 (4) ◽  
pp. 314
Author(s):  
Ye-Ri So ◽  
Ja-Won Koo ◽  
Young-Hak Cho ◽  
You-Cheol Hwang ◽  
Kyu-Jeung Ahn ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Fulminant Type 1 Diabetes ◽  
Leukocyte Antigen ◽  
Fulminant Type

Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan

2018 ◽  
Vol 19 (4) ◽  
pp. 699-706
Author(s):  
Yi-Ching Tung ◽  
Cathy S-J Fann ◽  
Chien-Ching Chang ◽  
Chen-Chung Chu ◽  
Wei-Shiung Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Type 1 Diabetes Mellitus ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients

2005 ◽  
Vol 12 (1) ◽  
pp. 213-217 ◽  
Author(s):  
Ayesha A. Motala ◽  
Marc Busson ◽  
Einas M. Al-Harbi ◽  
Manal A. A. Khuzam ◽  
Emtiaz M. D. Al-Omari ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Leukocyte Antigen ◽  
Insulin Dependent

ABSTRACT Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6 ± 8.2 years; mean duration of diabetes, 7.7 ± 7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 of 89 for controls, P < 0.001) and 89 healthy subjects was done by PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562, P = 0.019) and DRB1*070101 (0.2151 versus 0.0843, P < 0.001) were positively associated, while DRB1*110101 (0.0698 versus 0.1461, P = 0.014) and DRB1*160101 (0.0640 versus 0.1236, P = 0.038) were negatively associated with type 2 diabetes. DRB1*040101-DQB1*0302 (0.069 versus 0.0007; P = 0.004), DRB1*070101-DQB1*0201 (0.178 versus 0.0761, P = 0.007), DRB1*070101-DQB1*050101 (0.125 versus 0.0310, P = 0.002), and DRB1*150101-DQB1*060101 (0.0756 versus 0.0281, P = 0.008) were more prevalent among patients, while DRB1*160101-DQB1*050101 (0.0702 versus 0.0349, P = 0.05) was more prevalent among controls, conferring disease susceptibility or protection, respectively. In Bahrainis with type 2 diabetes, there is a significant association with select HLA class II genotypes, which were distinct from those in type 1 diabetes.

scholarly journals Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Mohamed Jahromi ◽  
Ebaa Al-Ozairi
Keyword(s):  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Incidence Rate ◽  
Disease Onset ◽  
Human Leukocyte ◽  
Arab Countries ◽  
World Health ◽  
Leukocyte Antigen ◽  
Prospective Longitudinal

The incidence rate of type 1 diabetes in Kuwait had been increasing exponentially and has doubled in children≤14 years old within almost two decades. Therefore, there is a dire need for a careful systematic familial cohort study. Several immunogenetic factors affect the pathogenesis of the disease. The human leukocyte antigen (HLA) accounts for the major genetic susceptibility to the disease. The triggering agents initiate disease onset by type 1 destruction of pancreatic β-cells. Both HLA and anti-islet antibodies can be used to characterize, predict susceptibility to the disease, innovate, or delay the β-cell destruction. Evidence from prospective longitudinal studies suggested that the underlying disease process represents a continuum that begins before the symptoms are clinically evident. Autoimmunity of the functional pancreatic β-cells results in symptomatic type 1 diabetes and lifelong insulin dependence. The autoantibodies against glutamic acid decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA), and zinc transporter-8 (ZnT-8A) comprise the most reliable biomarkers for type 1 diabetes in both children and adults. Although Kuwait is the second among the top 10 countries with a high incidence rate of type 1 diabetes, there have been no proper diagnostic and prediction tools as per the World Health Organization. The Kuwaiti Type 1 Diabetes Study (KADS) was initiated to understand the disease pathogenesis as well as the HLA and anti-islet autoantibody profile of type 1 diabetes in Kuwait. Understanding the disease sequela in a homogenous gene pool and highly consanguineous population of Kuwaitis could help solve the challenges and pathogenesis, as well as hasten the prevention, of type 1 diabetes.

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