scholarly journals TEK BEYİN METASTAZLI HASTALARDA TÜM BEYİN VE SİMÜLTANE ENTEGRE BOOST RADYOTERAPİSİ / WHOLE BRAIN RADIOTHERAPY (WBRT) WITH SIMULTANEOUS INTEGRATED BOOST (SIB) IN PATIENTS WITH SINGLE BRAIN METASTASIS

2016 ◽  
Vol 38 (0) ◽  
Author(s):  
Alaattin Özen ◽  
Melek Akçay ◽  
Suzan Şanlısoy ◽  
Evrim Metcalfe ◽  
Durmuş Etiz
Keyword(s):  
Brain Metastasis ◽  
Whole Brain Radiotherapy ◽  
Simultaneous Integrated Boost ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis ◽  
Integrated Boost

A new option in brain-metastases: Hippocampal-sparing whole-brain radiotherapy with simultaneous integrated boost VMAT-IGRT.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13589-e13589
Author(s):  
Alicia Marin ◽  
Margarita Martin ◽  
Emma Gonzalez ◽  
Lisselott Torres ◽  
David Hernandez ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Whole Brain Radiotherapy ◽  
Progression Free Survival ◽  
Simultaneous Integrated Boost ◽  
Rank Test ◽  
Whole Brain ◽  
Free Survival ◽  
Brain Radiotherapy ◽  
Integrated Boost ◽  
Hippocampal Sparing

e13589 Background: We report our experience with volumetric modulated arc therapy (VMAT-IGRT) use to plan and deliver whole brain radiotherapy whit a simultaneous integrated boost in patients with brain metastases, using hippocampal sparing. Methods: In this retrospective study 57 patients with brain metastases were treated with radiotherapy VMAT-IGRT were administered in 12 daily fractions of 2.7Gy for a total of 32.4Gy (EBD 40Gy) to whole-brain and simultaneous integrated boost to brain metastases, multiple targets, in 12 fractions to 3.4Gy for a total dose of 40.8Gy (EBD 60Gy). The primary endpoint was intracranial progression-free survival (PFS) and secondary endpoints were preserves neurocognitive function and overall survival (OS). Survival rates were determined by Kaplan-Meier method. Differences between survival curves were analyzed by the log-rank test. Results: From January 2015 to December 2018, 57 patients were enrolled. The median follow-up time was 7 months. PFS6, PFS12 and PFS18 were 91.3%, 70.8% and 70.8% respectively. mOS, OS6, OS12 and OS18 were 10 months (95% IC 4.2-15.7 months), 67.2%, 48.6% and 35.3% respectively. Response rates were as follows: 29RC (50.9%), 21RP (36.8%), 7SD (12.3%) and 0PD (0%). Long progression-free survival patients: PFS > 12, 15 and 18 months for initial diagnosis 70%, 70% and 70% respectively. Conclusions: Whole-brain radiotherapy with simultaneous integrated boost to brain-metastases: VMAT-IGRT is safe and promising and possibly produces survival and tolerance benefits. Sparing the hippocampus during cranial irradiation poses important technical challenges with respect to contouring and treatment planning.

scholarly journals OC-0348: Tumor bed radiosurgery vs. whole brain radiotherapy after surgery of single brain metastasis

2016 ◽  
Vol 119 ◽  
pp. S160
Author(s):  
L. Kepka ◽  
D. Tyc-Szczepaniak ◽  
K. Bujko ◽  
M. Olszyna-Serementa ◽  
W. Michalski ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Tumor Bed ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis
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