Comparison of Clinical Outcomes of Surgery Followed by Local Brain Radiotherapy and Surgery Followed by Whole Brain Radiotherapy in Patients With Single Brain Metastasis: Single-Center Retrospective Analysis

2011 ◽  
Vol 81 (4) ◽  
pp. e475-e480 ◽  
Author(s):  
Kenji Hashimoto ◽  
Yoshitaka Narita ◽  
Yasuji Miyakita ◽  
Makoto Ohno ◽  
Minako Sumi ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Retrospective Analysis ◽  
Clinical Outcomes ◽  
Whole Brain Radiotherapy ◽  
Single Center ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis ◽  
Local Brain

Outcomes of Surgery followed by Local Brain Radiotherapy Compared with Surgery followed by Whole Brain Radiotherapy for Single Brain Metastasis

2017 ◽  
Vol 103 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Hiroshi Igaki ◽  
Ken Harada ◽  
Rei Umezawa ◽  
Yasuji Miyakita ◽  
Makoto Ohno ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Causes Of Death ◽  
Whole Brain Radiotherapy ◽  
Salvage Treatment ◽  
Survival Times ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis ◽  
Local Brain ◽  
Treatment Application

Purpose To determine the clinical efficacy of surgery followed by local brain radiotherapy (LBRT) for patients with a single brain metastasis, by comparing the results with those of postoperative whole brain radiotherapy (WBRT). Methods We performed a retrospective analysis to compare the survival rate, recurrence-free rates, and causes of death for single brain metastasis patients who underwent surgery followed by LBRT or WBRT in the 2010-2015 period. Results After their surgery, 22 and 32 patients were treated by LBRT and WBRT, respectively. The median survival times for these LBRT and WBRT groups were 18.3 months and 19.2 months, respectively (p = 0.356). The local recurrence-free rates were 81.2% at 1 year and 81.2% at 2 years after LBRT, and 63.8% at 1 year and 58.9% at 2 years after WBRT (p = 0.589). The distant brain recurrence-free rates were 42.5% at 1 year and 25.5% at 2 years after LBRT, and 69.8% at 1 year and 52.4% at 2 years after WBRT (p = 0.044). Distant brain recurrences were observed significantly more frequently in the LBRT group, but the rates of salvage treatment application and survival were not significantly different between the LBRT and WBRT groups. The probability of neurologic death was not significantly higher in the LBRT group compared with the WBRT group. Conclusions Surgery followed by LBRT for single brain metastasis is not inferior to postoperative WBRT, because survival and the necessity of salvage treatment after LBRT were equivalent to those after WBRT.

scholarly journals OC-0348: Tumor bed radiosurgery vs. whole brain radiotherapy after surgery of single brain metastasis

2016 ◽  
Vol 119 ◽  
pp. S160
Author(s):  
L. Kepka ◽  
D. Tyc-Szczepaniak ◽  
K. Bujko ◽  
M. Olszyna-Serementa ◽  
W. Michalski ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Tumor Bed ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis

scholarly journals Single brain metastasis: Radiosurgery alone compared with radiosurgery plus up-front whole-brain radiotherapy

Cancer ◽  
2011 ◽  
Vol 118 (11) ◽  
pp. 2980-2985 ◽  
Author(s):  
Dirk Rades ◽  
Dagmar Hornung ◽  
Theo Veninga ◽  
Steven E. Schild ◽  
Jan Gliemroth
Keyword(s):  
Brain Metastasis ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis

Stereotactic radiotherapy of the tumor bed compared to whole brain radiotherapy after surgery of single brain metastasis: Results from a randomized trial

2016 ◽  
Vol 121 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Lucyna Kępka ◽  
Dobromira Tyc-Szczepaniak ◽  
Krzysztof Bujko ◽  
Marta Olszyna-Serementa ◽  
Wojciech Michalski ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Randomized Trial ◽  
Stereotactic Radiotherapy ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Tumor Bed ◽  
Brain Radiotherapy ◽  
Single Brain Metastasis
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