scholarly journals The potential role of exercise in chronic stress-related changes in AMPA receptor phenotype underlying synaptic plasticity

2017 ◽  
Vol 21 (4) ◽  
pp. 11-15
Author(s):  
Yea-Hyun Leem
Keyword(s):  
Synaptic Plasticity ◽  
Chronic Stress ◽  
Ampa Receptor ◽  
Potential Role ◽  
Receptor Phenotype

scholarly journals The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity

Neuron ◽  
2007 ◽  
Vol 54 (6) ◽  
pp. 859-871 ◽  
Author(s):  
John T.R. Isaac ◽  
Michael C. Ashby ◽  
Chris J. McBain
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Receptor Function

scholarly journals Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51

2014 ◽  
Vol 222 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Georgia Balsevich ◽  
Andres Uribe ◽  
Klaus V Wagner ◽  
Jakob Hartmann ◽  
Sara Santarelli ◽  
...  
Keyword(s):  
Chronic Stress ◽  
High Fat Diet ◽  
Metabolic Regulation ◽  
Potential Role ◽  
Body Weight Gain ◽  
Fk506 Binding Protein ◽  
Diet Induced Obesity ◽  
Chronic Social Defeat Stress ◽  
Novel Target

While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface remain elusive. The FK506-binding protein 51 (FKBP51, gene:Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric disorders and is a possible candidate for involvement in stress and metabolic regulation. The aims of the current study are to investigate the interaction between chronic stress and an obesogenic context and to additionally examine whether FKBP51 is involved in this interaction. For this purpose, male C57BL/6 mice were exposed to a high-fat diet for 8 weeks before being challenged with chronic social defeat stress. Herein, we demonstrate that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin. We show thatFkbp5expression is responsive to diet and stress in the hypothalamus and hippocampus respectively. Furthermore, under basal conditions, higher levels of hypothalamicFkbp5expression were related to increased body weight gain. Our data indicate thatFkbp5may represent a novel target in metabolic regulation.

scholarly journals Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress

2018 ◽  
Author(s):  
Ziyin Wu ◽  
Yingxue Fu ◽  
Yinfeng Yang ◽  
Chao Huang ◽  
Chunli Zheng ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Chronic Stress ◽  
Low Dose ◽  
Anxiety And Depression ◽  
Antidepressant Effects ◽  
Subsequent Activation

AbstractThe endogenous metabolite methylglyoxal (MGO) has recently emerged as a potential mediator of psychiatric disorders, such as anxiety and depression, but its precise mechanism of action remains poorly understood. Here, we find that MGO concentrations are decreased in the prefrontal cortex and hippocampus in rats subjected to chronic stress, and low-dose MGO treatment remarkedly enhances resilience to stress and alleviates depression-like symptoms. This effect is achieved by MGO’s promotion on the synaptic plasticity in prefrontal cortex and hippocampus. Both in vitro and in vivo experiments show that MGO provokes the dimerization and autophosphorylation of TrkB and the subsequent activation of downstream Akt/CREB signaling, which leads to a rapid and sustained expression of brain-derived neurotrophic factor (BDNF). We further demonstrate that MGO directly binds to the extracellular domain of TrkB, but not its intracellular domain. In addition, we also identify a natural product luteolin and its derivative lutD as potent inhibitors of Glyoxalase 1 and validate their antidepressant effects in chronic stress rat models. The antidepressant role of endogenous MGO provides a new basis for the understanding and therapeutic intervention design for stress-associated mental disorders.

scholarly journals Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation

2020 ◽  
Author(s):  
Luís F. Ribeiro ◽  
Tatiana Catarino ◽  
Mário Carvalho ◽  
Sandra D. Santos ◽  
Luísa Cortes ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Physiological Role ◽  
Long Term Potentiation ◽  
Receptor Activity ◽  
Constitutive Activity ◽  
Ghrelin Receptor

AbstractThe ability of animals to store and retrieve food caches in the wild requires the integration of biological signals of hunger, satiety and memory. The role of ghrelin in regulating feeding and memory makes ghrelin receptors an important target to shape the required cellular and molecular responses. We investigated the effects of the high ligand-independent activity of the ghrelin receptor on the physiology of excitatory synapses. Blocking this type of activity produced a decrease in the synaptic content of AMPA receptors in hippocampal neurons and a reduction in GluA1 phosphorylation at Ser845. Impaired constitutive activity from the ghrelin receptor increased surface diffusion of AMPA receptors and impaired AMPA receptor synaptic delivery mediated by chemical long-term potentiation. These observations support a role for the constitutive activity of the ghrelin receptor in regulating AMPA receptor trafficking under basal conditions and synaptic plasticity. Accordingly, we found that blocking the ghrelin receptor constitutive activity impairs spatial and recognition memory.Impact statementThis work uncovers a role for the constitutive activity of the ghrelin receptor in memory, and in the regulation of the synaptic levels of AMPA receptors, their mobility and synaptic plasticity. Underscoring the importance of deciphering the physiological role of constitutive ghrelin receptor activity, ghrelin receptor inverse agonism is now being considered as a therapy to treat alcohol use disorder.

scholarly journals The potential role of neuroinflammation and synaptic plasticity for neuropsychiatric symptoms

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Hellen Blum ◽  
Ludwig Lausser ◽  
Björn von Einem ◽  
Patrick Fissler ◽  
Iris‐Tatjana Kolassa ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Potential Role ◽  
Neuropsychiatric Symptoms

Role of ampa receptor endocytosis in synaptic plasticity

2001 ◽  
Vol 2 (5) ◽  
pp. 315-324 ◽  
Author(s):  
Reed C. Carroll ◽  
Eric C. Beattie ◽  
Mark von Zastrow ◽  
Robert C. Malenka
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Receptor Endocytosis
Sign in / Sign up

Export Citation Format

Share Document