Role of ampa receptor endocytosis in synaptic plasticity

2001 ◽  
Vol 2 (5) ◽  
pp. 315-324 ◽  
Author(s):  
Reed C. Carroll ◽  
Eric C. Beattie ◽  
Mark von Zastrow ◽  
Robert C. Malenka
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Receptor Endocytosis

scholarly journals The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity

Neuron ◽  
2007 ◽  
Vol 54 (6) ◽  
pp. 859-871 ◽  
Author(s):  
John T.R. Isaac ◽  
Michael C. Ashby ◽  
Chris J. McBain
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Receptor Function

scholarly journals Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity

2016 ◽  
Vol 291 (34) ◽  
pp. 17602-17615 ◽  
Author(s):  
Andrea R. Di Sebastiano ◽  
Sandra Fahim ◽  
Henry A. Dunn ◽  
Cornelia Walther ◽  
Fabiola M. Ribeiro ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Endocytosis ◽  
Metabotropic Glutamate ◽  
Group I

scholarly journals Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation

2020 ◽  
Author(s):  
Luís F. Ribeiro ◽  
Tatiana Catarino ◽  
Mário Carvalho ◽  
Sandra D. Santos ◽  
Luísa Cortes ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Physiological Role ◽  
Long Term Potentiation ◽  
Receptor Activity ◽  
Constitutive Activity ◽  
Ghrelin Receptor

AbstractThe ability of animals to store and retrieve food caches in the wild requires the integration of biological signals of hunger, satiety and memory. The role of ghrelin in regulating feeding and memory makes ghrelin receptors an important target to shape the required cellular and molecular responses. We investigated the effects of the high ligand-independent activity of the ghrelin receptor on the physiology of excitatory synapses. Blocking this type of activity produced a decrease in the synaptic content of AMPA receptors in hippocampal neurons and a reduction in GluA1 phosphorylation at Ser845. Impaired constitutive activity from the ghrelin receptor increased surface diffusion of AMPA receptors and impaired AMPA receptor synaptic delivery mediated by chemical long-term potentiation. These observations support a role for the constitutive activity of the ghrelin receptor in regulating AMPA receptor trafficking under basal conditions and synaptic plasticity. Accordingly, we found that blocking the ghrelin receptor constitutive activity impairs spatial and recognition memory.Impact statementThis work uncovers a role for the constitutive activity of the ghrelin receptor in memory, and in the regulation of the synaptic levels of AMPA receptors, their mobility and synaptic plasticity. Underscoring the importance of deciphering the physiological role of constitutive ghrelin receptor activity, ghrelin receptor inverse agonism is now being considered as a therapy to treat alcohol use disorder.

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