scholarly journals Nephrotic syndrome and duplication of the inferior vena cava: a series of unfortunate events

Author(s):  
Katarzyna Klejna ◽  
Tomasz Hryszko ◽  
Radosław Zawadzki ◽  
Beata Naumnik
1965 ◽  
Vol 41 (472) ◽  
pp. 88-93 ◽  
Author(s):  
T. J. Bayley ◽  
D. Heath ◽  
J. Hardwicke ◽  
A. G. W. Whitfield

2021 ◽  
Author(s):  
Hanan El-Halaby ◽  
Ashraf Bakr ◽  
Mohamed El-Assmy ◽  
Hussein Abdelaziz Abdalla ◽  
Marwa Salem ◽  
...  

Abstract Evaluating the volume status in children with Idiopathic nephrotic syndrome (INS) is mandatory to guide treatment and avoid unnecessary possibly hazardous albumin use. This study aimed to evaluate and compare the available tools used for volume status assessment and differentiating type of edema in children with INS. Sixty children with active INS were included and subdivided into hypovolemic and non-hypovolemic groups based on fractional excretion of sodium (FeNa%) and clinical assessment. All patients were studied for Inferior vena cava collapsibility index (IVCCI), plasma atrial natriuretic peptide (ANP) concentration and Body composition monitor (BCM). Forty-four patients (77.3%) had non-hypovolemic and 16 (26.7%) had hypovolemic states. Plasma ANP levels didn’t differ between hypovolemic and non-hypovolemic subgroups. IVCCI was higher in hypovolemic group (p<0.001) with sensitivity 87.5% and specificity 81.8% for hypovolemia detection while BCM-over hydration (BCM-OH) values were higher in non-hypovolemic group (p=0.04) with sensitivity= 68.2% and specificity =75% for detection of hypervolemia. FeNa% showed negative significant correlation with IVCCI (r= -0.578, p <0.001) and positive significant correlation with BCM-OH (r= 0.33, p=0.018), while FeNa% showed non-significant correlation to plasma ANP concentration (p=0.25). Conclusion: Non-hypovolemic edema is more frequent in edematous INS children than hypovolemic states. IVCCI is a reliable non-invasive bedside tool for evaluating volume status in INS children and is superior to BCM while plasma ANP levels can’t discriminate type of edema in INS.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Mohamed Osman Omar Jeele ◽  
Rukia Omar Barei Addow ◽  
Mohamed Farah Yusuf Mohamud

AbstractNephrotic syndrome (NS) was first described in 1827 as the presence of proteinuria of ≥ 3.5 g/24 h, hypoalbuminemia < 3.0 g/dl, peripheral edema, hyperlipidemia, lipiduria, and increased thrombotic risk. Nephrotic syndrome has an incidence of three cases per 100,000 each year in adults. Nephrotic syndrome also has serious complications due to hypercoagulable state in both various venous and arteries which could lead thromboembolic events. The pathophysiology of hypercoagulability in the nephrotic syndrome is due to an imbalance of prothrombotic and antithrombotic factors, as well as impaired thrombolytic activities.Here, we will present a 19-year-old woman who presented to the emergency department complaining of chest pain and shortness of breath for 3 days. The patient was quickly diagnosed with pulmonary embolism and inferior vena cava thrombosis as a complication of nephrotic syndrome, allowing prompt initiation of anticoagulant therapy. After 2 weeks of admission, the patient’s condition resolved, her laboratory results returned to almost normal and the patient was discharged with oral prednisolone, coumadin, atorvastatin, and ramipril. We aim to determine which is the likely cause of pulmonary embolism in patients with nephrotic syndrome.


2020 ◽  
Author(s):  
Mohamed Osman Jeele ◽  
Mohamed Farah Yusuf Mohamud ◽  
Rukia Omar Barre Addow

Abstract Nephrotic syndrome (NS); the first described in 1827 as the presence of proteinuria of ≥ 3.5 g/24 hours, albuminemia < 3.0 g, peripheral edema, hyperlipidemia, lipiduria, and increased thrombotic risk which has an incidence of three new cases per 100 000 each year in adults. Nephrotic syndrome had complicated by the induction of a hypercoagulable state with both various venous and arterial thromboembolic events. The pathophysiology of hypercoagulability in the nephrotic syndrome is imbalances of prothrombotic and antithrombotic factors, as well as impaired thrombolytic activity occurs. Here we present, a 19 years old female came to the emergency department with a complaint of chest pain and shortness of breath for three days. The patient quickly diagnosed pulmonary embolism and inferior vena cava thrombosis as a complication of nephrotic syndrome, allowing prompt initiation of anticoagulant therapy. After two weeks of admission, the patient's resolved dramatically, and his laboratory results returned to almost normal, and the patient discharged with Oral Prednisolone, Coumadin, Atorvastatin, and Ramipril. We aim to determine which is the likely cause of pulmonary embolism in patients with the nephrotic syndrome.


2001 ◽  
Vol 16 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Osman Dönmez ◽  
Sevgi Mir ◽  
Ruhi Özyürek ◽  
Alphan Cura ◽  
Caner Kabasakal

1995 ◽  
Vol 9 (4) ◽  
pp. 237-241 ◽  
Author(s):  
Lee-shing Chu ◽  
Cheng-pei Chang ◽  
Ren-shyan Liu ◽  
Sinclair Wynchank ◽  
Ming-huei Sheu ◽  
...  

2019 ◽  
Vol 6 (3) ◽  
pp. 1298
Author(s):  
Deepesh Gupta ◽  
Kusum Devpura ◽  
Kamlesh Kumar Agrawal

Background: There is triad of hypoalbuminemia, edema, and hyperlipidemia in nephrotic syndrome patients. Management of nephrotic syndrome includes general measures like fluid restriction, emergency albumin transfusions and diuretics that provide symptomatic relief till steroids act. These measures require an assessment of body fluid volume to avoid circulatory failure which is very difficult in these patients because of edema. The objective of the study was to measure and compare the Inferior Vena Cava (IVC) Index and Inferior Vena Cava Collapsibility (IVCC) Index by ultrasound as a measure of body fluid volume status in children with nephrotic syndrome.Methods: The present observational study was conducted in all children of age more than 1 year up to 18 year. There were two groups; group 1 was nephrotic syndrome patients-Initial episode or in relapse and group 2 (Control) was age and sex-matched non-nephrotic children. IVC index and IVCC index were measured and compared in both the groups.Results: Mean value of minimum diameter of IVC during inspiration in cases was 5.91±1.60 mm as compared to 4.53±0.94 mm in controls which was significantly higher in case group {P ˂0.0001}. Mean value of IVC index in cases was 0.88±0.20 cm/m2 as compared to 0.93±0.19 cm/m2 in controls which was non-significant. Mean value of IVCC index in cases (35.61±13.68) was significantly less as compared to controls (52.23±2.01) {P ˂0.0001}.Conclusions: The present study concluded that IVCC index is better indicator of body fluid volume status in nephrotic patients as compare to IVC index.


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