scholarly journals Pharmacological and Medicinal Chemistry Aspects of Cannabis Compounds

2011 ◽  
Vol 6 (2) ◽  
pp. 16-18
Author(s):  
T. Cotelea
Keyword(s):  
Chemical Analysis ◽  
Functional Groups ◽  
Medicinal Chemistry ◽  
Spatial Arrangement ◽  
Pharmacological Action ◽  
Scientific Interest ◽  
General Overview

The current communication includes a general overview of the scientific interest and medicianl chemistry aspects of Cannabis compounds. It relates to metabolism, pharmacological action and phisico-chemical analysis of these compounds, as well as of some isomers differing in spatial arrangement of functional groups.

scholarly journals Metal Complexes of Oxadiazole Ligands: An Overview

2019 ◽  
Vol 20 (14) ◽  
pp. 3483 ◽  
Author(s):  
Giovanni Salassa ◽  
Alessio Terenzi
Keyword(s):  
Metal Complexes ◽  
Medicinal Chemistry ◽  
Heterocyclic Ring ◽  
Organic Ligands ◽  
Ring Systems ◽  
General Overview ◽  
Research Fields ◽  
Scientific Disciplines ◽  
Synthetic Approaches

Oxadizoles are heterocyclic ring systems that find application in different scientific disciplines, from medicinal chemistry to optoelectronics. Coordination with metals (especially the transition ones) proved to enhance the intrinsic characteristics of these organic ligands and many metal complexes of oxadiazoles showed attractive characteristics for different research fields. In this review, we provide a general overview on different metal complexes and polymers containing oxadiazole moieties, reporting the principal synthetic approaches adopted for their preparation and showing the variety of applications they found in the last 40 years.

scholarly journals Late stage C–H functionalization via chalcogen and pnictogen salts

2020 ◽  
Vol 11 (37) ◽  
pp. 10047-10060
Author(s):  
Christopher B. Kelly ◽  
Rosaura Padilla-Salinas
Keyword(s):  
Functional Groups ◽  
Late Stage ◽  
Potential Application ◽  
Medicinal Chemistry

Three unrelated cationic groups, which can replace C–H bonds late stage, have been identified as progenitors to various functional groups. This review discusses the chemistry of these salts and their potential application in medicinal chemistry.

scholarly journals Recent Advances in Indazole-Containing Derivatives: Synthesis and Biological Perspectives

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2783 ◽  
Author(s):  
Shu-Guang Zhang ◽  
Chao-Gen Liang ◽  
Wei-Hua Zhang
Keyword(s):  
Functional Groups ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Drug Molecules ◽  
Recent Advances

Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. Diversely substituted indazole derivatives bear a variety of functional groups and display versatile biological activities; hence, they have gained considerable attention in the field of medicinal chemistry. This review aims to summarize the recent advances in various methods for the synthesis of indazole derivatives. The current developments in the biological activities of indazole-based compounds are also presented.

scholarly journals Synthesis of 3-alkenylindoles through regioselective C–H alkenylation of indoles by a ruthenium nanocatalyst

2020 ◽  
Vol 16 ◽  
pp. 140-148 ◽  
Author(s):  
Abhijit Paul ◽  
Debnath Chatterjee ◽  
Srirupa Banerjee ◽  
Somnath Yadav
Keyword(s):  
Functional Groups ◽  
Medicinal Chemistry ◽  
Catalytic Efficiency ◽  
Three Phase ◽  
Electron Donating Groups

3-Alkenylindoles are biologically and medicinally very important compounds, and their syntheses have received considerable attention. Herein, we report the synthesis of 3-alkenylindoles via a regioselective alkenylation of indoles, catalysed by a ruthenium nanocatalyst (RuNC). The reaction tolerates several electron-withdrawing and electron-donating groups on the indole moiety. Additionally, a “robustness screen” has also been employed to demonstrate the tolerance of several functional groups relevant to medicinal chemistry. With respect to the Ru nanocatalyst, it has been demonstrated that it is recoverable and recyclable up to four cycles. Also, the catalyst acts through a heterogeneous mechanism, which has been proven by various techniques, such as ICPMS and three-phase tests. The nature of the Ru nanocatalyst surface has also been thoroughly examined by various techniques, and it has been found that the oxides on the surface are responsible for the high catalytic efficiency of the Ru nanocatalyst.

Glycan Carriers As Glycotools for Medicinal Chemistry Applications

2019 ◽  
Vol 26 (35) ◽  
pp. 6349-6398
Author(s):  
Mattia Vacchini ◽  
Rana Edwards ◽  
Roberto Guizzardi ◽  
Alessandro Palmioli ◽  
Carlotta Ciaramelli ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Protein Interactions ◽  
Medicinal Chemistry ◽  
Specific Area ◽  
Literature Survey ◽  
Present Review ◽  
General Overview ◽  
Signaling Events ◽  
Cellular Behaviors ◽  
Carrier Systems

Carbohydrates are one of the most powerful and versatile classes of biomolecules that nature uses to regulate organisms’ biochemistry, modulating plenty of signaling events within cells, triggering a plethora of physiological and pathological cellular behaviors. In this framework, glycan carrier systems or carbohydrate-decorated materials constitute interesting and relevant tools for medicinal chemistry applications. In the last few decades, efforts have been focused, among others, on the development of multivalent glycoconjugates, biosensors, glycoarrays, carbohydrate-decorated biomaterials for regenerative medicine, and glyconanoparticles. This review aims to provide the reader with a general overview of the different carbohydrate carrier systems that have been developed as tools in different medicinal chemistry approaches relying on carbohydrate-protein interactions. Given the extent of this topic, the present review will focus on selected examples that highlight the advancements and potentialities offered by this specific area of research, rather than being an exhaustive literature survey of any specific glyco-functionalized system.

scholarly journals Role of N–Oxide Moieties in Tuning Supramolecular Gel-State Properties

Gels ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. 41
Author(s):  
Dipankar Ghosh ◽  
Ragnar Bjornsson ◽  
Krishna K. Damodaran
Keyword(s):  
Functional Groups ◽  
Self Assembly ◽  
Network Formation ◽  
Spatial Arrangement ◽  
Sem Images ◽  
Thermal Stabilities ◽  
Supramolecular Gel ◽  
Low Molecular Weight Gelators ◽  
Gel Network

The role of specific interactions in the self-assembly process of low molecular weight gelators (LMWGs) was studied by altering the nonbonding interactions responsible for gel formation via structural modification of the gelator/nongelator. This was achieved by modifying pyridyl moieties of bis(pyridyl) urea-based hydrogelator (4–BPU) and the isomer (3–BPU) to pyridyl N–oxide compounds (L1 and L2, respectively). The modification of the functional groups resulted in the tuning of the gelation properties of the parent gelator, which induced/enhanced the gelation properties. The modified compounds displayed better mechanical and thermal stabilities and the introduction of the N–oxide moieties had a prominent effect on the morphologies of the gel network, which was evident from the scanning electron microscopy (SEM) images. The effect of various interactions due to the introduction of N–oxide moieties in the gel network formation was analyzed by comparing the solid-state interactions of the compounds using single crystal X-ray diffraction and computational studies, which were correlated with the enhanced gelation properties. This study shows the importance of specific nonbonding interactions and the spatial arrangement of the functional groups in the supramolecular gel network formation.

scholarly journals Transformation of 2H-1,2,3-benzothiadiazine 1,1-dioxides variously substituted at the aromatic ring, via nucleophilic substitution and demethylation reactions

2020 ◽  
Author(s):  
Imre Gyűjtő ◽  
Márta Porcs-Makkay ◽  
Ernák Ferenc Várda ◽  
Gyöngyvér Pusztai ◽  
Gábor Tóth ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Functional Groups ◽  
Aromatic Ring ◽  
Methoxy Group ◽  
Medicinal Chemistry ◽  
Building Blocks ◽  
Chlorine Atoms ◽  
New Methods ◽  
Pharmacological Interest

2H‑1,2,3‑Benzothiadiazine 1,1-dioxides are a class of compounds of pharmacological interest. After earlier studies carried out at our laboratory on various transformations (alkylation, acylation, reduction) at the hetero ring, the present manuscript focuses on the transformation of substituents at the aromatic carbocycle, including nucleophilic substitution of chlorine atoms and demethylation of the methoxy group with amines. The new methods described here allow the introduction of versatile functional groups on the aromatic ring, making these compounds useful building blocks for organic and medicinal chemistry applications.

REVIEW ON THE SYNTHESIS AND POTENTIAL THERAPEUTIC APPLICATIONS OF HETEROCYCLIC PRODUCTS OF 5-AMINO-3-METHYLISOXAZOLE

2021 ◽  
Vol 12 (08) ◽  
pp. 154-172
Author(s):  
Tahira Saleem ◽  
Muhammad Humble Khalid Tareen ◽  
Muhammad Rashid ◽  
Mehwish Nawaz ◽  
Hina Aftab ◽  
...  
Keyword(s):  
Functional Groups ◽  
Building Block ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Drug Molecule ◽  
Therapeutic Applications ◽  
Biological Actions

In general, heterocyclic compounds have evoked interest and concern because of their fundamental role in biological profiles and biological actions in nature. Now, most of the lead molecules in medicinal chemistry are based on hetero-atoms. In medicinal chemistry- to bring two hetero-atoms to the drug molecule, isoxazoles are interesting functional groups. Isoxazole as a key building block has been widely used and is an important heterocyclic unit.

Sign in / Sign up

Export Citation Format

Share Document