Advantages of Autologous Platelet-Rich Fibrin Membrane on Gingival Crevicular Fluid Growth Factor Levels and Periodontal Healing: A Randomized Split-Mouth Clinical Study

2017 ◽  
Vol 88 (8) ◽  
pp. 771-777 ◽  
Author(s):  
Taner Arabacı ◽  
Oguz Kose ◽  
Mevlut Albayrak ◽  
Yasin Cicek ◽  
Alper Kizildag
Keyword(s):  
Clinical Study ◽  
Growth Factor ◽  
Gingival Crevicular Fluid ◽  
Platelet Rich Fibrin ◽  
Crevicular Fluid ◽  
Periodontal Healing ◽  
Autologous Platelet ◽  
Fibrin Membrane

Epidermal growth factor in gingival crevicular fluid and its binding capacity in inflamed and non-inflamed human gingiva

1996 ◽  
Vol 41 (7) ◽  
pp. 719-724 ◽  
Author(s):  
Kuang-Min Chang ◽  
Nina Lehrhaupt ◽  
Louis M. Lin ◽  
Jian Feng ◽  
Chi-Ying Wu-Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Gingival Crevicular Fluid ◽  
Binding Capacity ◽  
Human Gingiva ◽  
Epidermal Growth ◽  
Crevicular Fluid

scholarly journals CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Claudia Dellavia ◽  
Elena Canciani ◽  
Giulio Rasperini ◽  
Giorgio Pagni ◽  
Matteo Malvezzi ◽  
...  
Keyword(s):  
Surgical Procedures ◽  
Early Phase ◽  
Gingival Crevicular Fluid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Wound Fluid ◽  
Protein Levels ◽  
Inflammatory Phase ◽  
Crevicular Fluid ◽  
Open Flap Debridement ◽  
Periodontal Healing

Objectives. Cementogenesis seems to be significantly compromised during tissue inflammation. In dental practice, surgical procedures are performed with the aim to regenerate periodontium including cementum. However, inflammation that occurs during the initial healing phases after surgery may impair regeneration of this tissues. The aim of the present study was to assess if surgical procedures designed to regenerate periodontium might affect levels of cementum protein-1 (CEMP-1) in periodontal wound fluid during early phase of healing. Materials and Methods. In 36 patients, 18 intrabony periodontal defects were treated with regenerative therapy (REG group) and 18 suprabony periodontal defects were treated with open flap debridement (OFD group). In the experimental sites, gingival crevicular fluid was collected immediately before surgery, and periodontal wound fluid was collected 4, 7, 14, and 21 days after surgery. CEMP-1 levels were detected by indirect enzyme-linked immunosorbent assay technique. Results. At the analysis, it resulted that there was a significant average difference in CEMP-1 values between the REG and OFD groups at baseline (p=0.041), the CEMP-1-modeled average in the OFD group was lower by 0.45 ng/ml. There was a significant trend in CEMP-1 over time, and this trend was different among the 2 groups: the REG group showed a statistically significant rising CEMP-1 trend (0.18 ng/ml a week p=0.012), while the OFD had a trend that was significantly lower (-0.22 ng/ml a week compared to the REG group trend p=0.023), the OFD group lost on average 0.05 ng/ml a week. In REG sites, GCF protein levels resulted also related to clinical parameters. Conclusions. During the initial inflammatory phase of periodontal healing, CEMP-1 levels decrease regardless of the surgical protocol applied. The surgical procedures used to regenerate periodontal tissue are able to reverse this trend and to induce significant increase of CEMP-1 in periodontal wound fluid after the first week postop.

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