Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet-Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans

2016 ◽  
Vol 87 (11) ◽  
pp. 1253-1260 ◽  
Author(s):  
Jane K. Chadwick ◽  
Michael P. Mills ◽  
Brian L. Mealey
Keyword(s):  
Bone Allograft ◽  
Radiographic Evaluation ◽  
Intrabony Defects ◽  
Platelet Rich Fibrin ◽  
Freeze Dried

scholarly journals Clinical and radiographic evaluation of platelet-rich fibrin as an adjunct to bone grafting demineralized freeze-dried bone allograft in intrabony defects

2020 ◽  
Vol 24 (1) ◽  
pp. 60 ◽  
Author(s):  
Abhinav Atchuta ◽  
JagadishReddy Gooty ◽  
VikramReddy Guntakandla ◽  
SunilKumar Palakuru ◽  
Satyanarayana Durvasula ◽  
...  
Keyword(s):  
Bone Grafting ◽  
Bone Allograft ◽  
Radiographic Evaluation ◽  
Intrabony Defects ◽  
Platelet Rich Fibrin ◽  
Freeze Dried

scholarly journals Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated growth factor alone in the treatment of intrabony defects

2021 ◽  
Vol 94 (2) ◽  
pp. 220-228
Author(s):  
Tithi Vaid ◽  
Santosh Kumar ◽  
Rupal Mehta ◽  
Sujay Shah ◽  
Surabhi Joshi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Bone Allograft ◽  
T Test ◽  
Radiographic Evaluation ◽  
Control Group ◽  
Intrabony Defects ◽  
Freeze Dried ◽  
Intergroup Comparison ◽  
And Control

Background. Periodontal disease is one of the major causes of alveolar bone loss. There are various ways of regenerating the lost bone, i.e. guided tissue regeneration, bone grafts, and growth factors. In this purview, it becomes immensely important for a clinician to decide the best modality of treatment. In this study, we compared the effect of demineralized freeze-dried bone allograft (DFDBA) in combination with concentrated growth factors (CGF) verses CGF alone. Methods. This double-blind, split-mouth study was conducted on ten patients with two comparable bilateral intrabony defects. Each pair of defects was randomly treated by DFDBA + CGF or CGF alone. Clinical parameters such as plaque index (PI), modified gingival index (MGI), pocket probing depth (PPD), and relative attachment level (RAL) were recorded at baseline, three months, and six months. In addition, radiograph with grids was also taken at baseline and six months. The paired t-test was used to compare the pre- and post-treatment values and the unpaired t-test was used to compare the test and control group. Results. The PI score decreased significantly from baseline to six months. Similarly, the mean MGI score decreased significantly from baseline to six months. The intragroup comparison showed that there was a significant reduction in PPD in both the test and control group. However, the intergroup comparison showed that the reduced pocket depth was not significant. The intragroup radiographic comparison showed that there was the significant formation of bone in both the test and control group but inter-group showed that the formation of bone among both the group were non-significant. Conclusion. Radiographic and clinical outcomes of this study concluded that post six months, both groups demonstrated significant improvement in clinical and radiographic parameters. However, the addition of DFDBA to CGFs did not give any additional benefits.

scholarly journals Differences in results of infrabony pocket treatment with addition of platelet rich fibrin and platelet rich plasma gel in DFDBA bone graft

2019 ◽  
Vol 1 (1) ◽  
pp. 29
Author(s):  
Netta Anggraini ◽  
Sri Pramestri Lastianny ◽  
Al Sri Koes Soesilowati
Keyword(s):  
Bone Graft ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Bone Allograft ◽  
Graft Material ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Freeze Dried ◽  
Bone Height ◽  
Prp Gel

Treatment of infrabony pocket makes use of bone graft material demineralized freeze dried bone allograft (DFDBA) from different individuals which has undergone demineralization process and it is osteoinductive. Enhancement of growth factor was done by adding platelet rich fibrin (PRF) and platelet rich plasma (PRP). PRP is activated with an addition of calcium chloride CaCl2) to form gel. The method used to apply the bone grafting material is open flap debridement OFD). This research aimed to reveal the differences in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA. The sample was taken from 20 infrabony pocket points divided into 2 groups, 10 infrabony pocket were treated with OFD+DFDBA+PRF and the other were treated with OFD+DFDBA+PRP gel. Pocket depth (PD) was measured on the baseline and the first and third month after treatment. Alveolar bone height was measured using cone beam computed tomography (CBCT) radiograph on the baseline to the third month after treatment. The results of this research showed that there was difference in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA which could be observed from a reduction in PD from the baseline, month 1 and month 3 as well as reduction in alveolar bone height from the baseline to month 3. This research concluded that infrabony pocket treatment PRF application yields better results than PRP gel application in terms of PD and alveolar bone height reduction.

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