Effects of Surface Hydrophilicity and Microtopography on Early Stages of Soft and Hard Tissue Integration at Non-Submerged Titanium Implants: An Immunohistochemical Study in Dogs

2007 ◽  
Vol 78 (11) ◽  
pp. 2171-2184 ◽  
Author(s):  
Frank Schwarz ◽  
Daniel Ferrari ◽  
Monika Herten ◽  
Ilja Mihatovic ◽  
Marco Wieland ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Titanium Implants ◽  
Hard Tissue ◽  
Surface Hydrophilicity ◽  
Tissue Integration ◽  
Early Stages

P.228 Thymidylate synthase expression in oral carcinoma: an immunohistochemical study about early stages

2006 ◽  
Vol 34 ◽  
pp. 191
Author(s):  
M.F. Muñoz-Guerra ◽  
A. Capote ◽  
R. González ◽  
P. Martos ◽  
M.E. Fernández-Contreras ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
Immunohistochemical Study ◽  
Oral Carcinoma ◽  
Early Stages

Early Stages of Crystal Nucleation in Hard Tissue Formation

1981 ◽  
pp. 974-982 ◽  
Author(s):  
H. J. Höhling ◽  
J. Althoff ◽  
R. H. Barckhaus ◽  
E.-R. Krefting ◽  
G. Lissner ◽  
...  
Keyword(s):  
Crystal Nucleation ◽  
Tissue Formation ◽  
Hard Tissue ◽  
Early Stages

scholarly journals Manufacturing and Characterisation of Robot Assisted Microplasma Multilayer Coating of Titanium Implants : Biocompatible coatings for medical implants with improved density and crystallinity

2020 ◽  
Vol 64 (2) ◽  
pp. 180-191 ◽  
Author(s):  
D. Alontseva ◽  
E. Ghassemieh ◽  
S. Voinarovych ◽  
O. Kyslytsia ◽  
Y. Polovetskyi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Structural Integrity ◽  
New Technologies ◽  
Lower Layer ◽  
Multilayer Coating ◽  
Titanium Implants ◽  
Dense Layer ◽  
Medical Implants ◽  
Robot Assisted ◽  
Tissue Integration

This study focuses on new technologies for the production of medical implants using a combination of robotics and microplasma coatings. This involves robot assisted microplasma spraying (MPS) of a multilayer surface structure on a biomedical implant. The robot motion design provides a consistent and customised plasma coating operation. Based on the analytical model results, certain spraying modes were chosen to form the optimised composition and structure of the titanium/hydroxyapatite (HA) multilayer coatings. It is desirable that the Ti coated lower layer offer a dense layer to provide the implant with suitable structural integrity and the Ti porous layer and HA top layer present biocompatible layers which are suitable for implant and tissue integration. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) were used to analyse the structure of the coatings. The new robot assisted MPS technique resulting from this research provides a promising solution for medical implant technology.

Bioactive Composite Coating on Titanium Implants for Hard Tissue Repair

2007 ◽  
Vol 334-335 ◽  
pp. 1249-1252 ◽  
Author(s):  
Jin Ming Wu ◽  
Min Wang ◽  
Akiyoshi Osaka
Keyword(s):  
Composite Coating ◽  
Low Temperatures ◽  
Tissue Repair ◽  
Body Fluid ◽  
Titanium Implants ◽  
Apatite Formation ◽  
Hard Tissue ◽  
Layer Composite ◽  
Titania Layer ◽  
Hydrolysis Of

A bioactive composite coating consisting of one layer of titania and one layer of apatite was formed on Ti substrate. The first layer of crystalline titania was deposited on Ti at low temperatures either through oxidation of Ti by hydrogen peroxide solution or through hydrolysis of TiF4 or TiCl4 solution. It was shown that the crystalline titania, either in the form of anatase or rutile, induced formation of the second layer of apatite in a simulated body fluid. However, the trace elements in the titania layer affected greatly apatite formation. The Cl incorporated in the titania layer did not hinder apatite formation while F did. The two-layer composite coating should enhance bonding of Ti implants to bone tissue.

scholarly journals Clinical Longevity of Zirconia Implants with the Focus on Biomechanical and Biological Outcome

2020 ◽  
Vol 7 (4) ◽  
pp. 344-351
Author(s):  
Ralf-Joachim Kohal ◽  
David K. Dennison
Keyword(s):  
Systematic Reviews ◽  
Titanium Implants ◽  
Zirconia Ceramic ◽  
Published Data ◽  
Clinical Use ◽  
Short Term ◽  
Tissue Integration ◽  
Meta Review ◽  
Ceramic Implants ◽  
Zirconia Implants

Abstract Purpose of Review The goal of the present review is to update the reader on the scientific background of zirconia ceramic implants. Clinical investigations using zirconia ceramic implants over the last couple of years have brought up some new developments and questions. Can we be confident in placing zirconia ceramic implants given the recently published data? Is there a difference in the application of one- and two-piece implants? Recent Findings Systematic reviews on preclinical investigations of zirconia implants revealed that one-piece zirconia implants (> 4 mm) are sufficiently stable for clinical use. The same is true for some clinically available two-piece implant systems. Osseointegration and soft tissue integration are, according to the reviews, similar between titanium and zirconia implants with similar surface topographies. Regarding the clinical outcome, a meta-review exists evaluating systematic reviews. The findings of the systematic reviews and the meta-review are that there are good short-term clinical results for one-piece zirconia implants. However, the data for two-piece implants is not robust. Summary In certain applications (single tooth restorations and small bridges), the results of zirconia implants are comparable with titanium implants in short-term studies. Some mid-term investigations support the short-term results. However, according to the current scientific data available, zirconia implants cannot yet be considered an alternative to titanium implants because there are many areas where there is a lack of clinical studies on zirconia implants. Currently, they are an addendum to the titanium implant armamentarium for situations where they are useful (patient request, known hypersensitivity to titanium, or questions of esthetics when titanium might appear inappropriate for a certain situation/condition), but long-term studies are needed. Without a doubt, there is a need for two-piece zirconia implants, but limited research exists to support their clinical use at the moment.

scholarly journals Tissue integration of zirconia and titanium implants with and without buccal dehiscence defects—A histologic and radiographic preclinical study

2019 ◽  
Vol 30 (7) ◽  
pp. 660-669 ◽  
Author(s):  
Daniel S. Thoma ◽  
Hyun‐Chang Lim ◽  
Kyeong‐Won Paeng ◽  
Ui‐Won Jung ◽  
Christoph H. F. Hämmerle ◽  
...  
Keyword(s):  
Preclinical Study ◽  
Titanium Implants ◽  
Tissue Integration

scholarly journals Investigating the Response of Human Neutrophils to Hydrophilic and Hydrophobic Micro-Rough Titanium Surfaces

Materials ◽  
2020 ◽  
Vol 13 (15) ◽  
pp. 3421
Author(s):  
Karim El Kholy ◽  
Daniel Buser ◽  
Julia-Gabriella Wittneben ◽  
Dieter D. Bosshardt ◽  
Thomas E. Van Dyke ◽  
...  
Keyword(s):  
Human Serum ◽  
Dental Implants ◽  
Oxygen Radical ◽  
Titanium Implants ◽  
Tissue Response ◽  
Human Neutrophils ◽  
Surface Hydrophilicity ◽  
Radical Production ◽  
Oxygen Radical Production ◽  
Titanium Surfaces

Various treatments have been used to change both the topography and chemistry of titanium surfaces, aiming to enhance tissue response and reduce healing times of endosseous implants. Most studies to date focused on bone healing around dental implants occurring later during the healing cascade. However, the impact of the initial inflammatory response in the surgical wound site on the success and healing time of dental implants is crucial for implant integration and success, yet it is still poorly understood. The purpose of this study was to investigate the effect of titanium surface hydrophilicity on the response of human neutrophils by monitoring oxygen radical production, which was measured as chemiluminescence activity. Materials and Methods: Neutrophils were isolated from human donors’ blood buffy coats using the double sucrose gradient method. Neutrophils were exposed to both hydrophilic and hydrophobic titanium surfaces with identical topographies in the presence and absence of human serum. This resulted in six experimental groups including two different implant surfaces, with and without exposure to human serum, and two control groups including an active control with cells alone and a passive control with no cells. Two samples from each group were fixed and analyzed by SEM. Comparisons between surface treatments for differences in chemiluminescence values were performed using analysis of variance ANOVA. Results and Conclusion: In the absence of exposure to serum, there was no significant difference noted between the reaction of neutrophils to hydrophilic and hydrophobic surfaces. However, there was a significant reduction in the mean and active chemiluminescence activity of neutrophils to serum-coated hydrophilic titanium surfaces than to serum-coated hydrophobic titanium surfaces. This suggests that surface hydrophilicity promotes enhanced adsorption of serum proteins, which leads to decreased provocation of initial immune cells and reduction of local oxygen radical production during wound healing. This can help explain the faster osseointegration demonstrated by hydrophilic titanium implants.

The experimental study of tissue integration into porous titanium implants

2020 ◽  
pp. 112070002094348
Author(s):  
Rashid Tikhilov ◽  
Igor Shubnyakov ◽  
Alexey Denisov ◽  
Vladimir Konev ◽  
Iosif Gofman ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Bone Defect ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Control Group ◽  
Additive Technology ◽  
Tissue Integration ◽  
3D Printed ◽  
Tissue Attachment ◽  
Highly Porous

Introduction: Due to a lack of uniform shapes and sizes of bone defects in hip and knee joint pathology, their fixing could benefit from using individually manufactured 3D-printed highly porous titanium implants. The objective of this study was to evaluate the extent of bone and muscle tissue integration into porous titanium implants manufactured using additive technology. Materials and methods: Porous and non-porous titanium plates were implanted into the latissimus dorsi muscle and tibia of 9 rabbits. On days 1, 60 and 90 animals were examined with x-rays. On day 60 histological tests were carried out. On day 90 the tensile strength at the implant-tissue interface was tested. Results: Histological analysis of muscle samples with porous titanium implants showed integration of connective tissue and blood vessels into the pores. Bone defect analysis demonstrated bone ingrowth into the pores of titanium with a minimal amount of fibrous tissue. The tensile strength of the muscular tissue attachment to the porous titanium was 28 (22–30) N which was higher than that of the control group 8.5 (5–11) N. Bone tissue attachment strength was 148 (140–152) N in the experimental group versus 118 (84–122) N in the control group. Conclusions: Using additive technology in manufacturing 3D-printed highly porous titanium implants improves bone and muscle integration compared with the non-porous material of the control group. This could be a promising approach to bone defect repair in revision and reconstruction surgery.

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