scholarly journals Tissue integration of zirconia and titanium implants with and without buccal dehiscence defects—A histologic and radiographic preclinical study

2019 ◽  
Vol 30 (7) ◽  
pp. 660-669 ◽  
Author(s):  
Daniel S. Thoma ◽  
Hyun‐Chang Lim ◽  
Kyeong‐Won Paeng ◽  
Ui‐Won Jung ◽  
Christoph H. F. Hämmerle ◽  
...  
Keyword(s):  
Preclinical Study ◽  
Titanium Implants ◽  
Tissue Integration

scholarly journals Manufacturing and Characterisation of Robot Assisted Microplasma Multilayer Coating of Titanium Implants : Biocompatible coatings for medical implants with improved density and crystallinity

2020 ◽  
Vol 64 (2) ◽  
pp. 180-191 ◽  
Author(s):  
D. Alontseva ◽  
E. Ghassemieh ◽  
S. Voinarovych ◽  
O. Kyslytsia ◽  
Y. Polovetskyi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Structural Integrity ◽  
New Technologies ◽  
Lower Layer ◽  
Multilayer Coating ◽  
Titanium Implants ◽  
Dense Layer ◽  
Medical Implants ◽  
Robot Assisted ◽  
Tissue Integration

This study focuses on new technologies for the production of medical implants using a combination of robotics and microplasma coatings. This involves robot assisted microplasma spraying (MPS) of a multilayer surface structure on a biomedical implant. The robot motion design provides a consistent and customised plasma coating operation. Based on the analytical model results, certain spraying modes were chosen to form the optimised composition and structure of the titanium/hydroxyapatite (HA) multilayer coatings. It is desirable that the Ti coated lower layer offer a dense layer to provide the implant with suitable structural integrity and the Ti porous layer and HA top layer present biocompatible layers which are suitable for implant and tissue integration. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) were used to analyse the structure of the coatings. The new robot assisted MPS technique resulting from this research provides a promising solution for medical implant technology.

scholarly journals Clinical Longevity of Zirconia Implants with the Focus on Biomechanical and Biological Outcome

2020 ◽  
Vol 7 (4) ◽  
pp. 344-351
Author(s):  
Ralf-Joachim Kohal ◽  
David K. Dennison
Keyword(s):  
Systematic Reviews ◽  
Titanium Implants ◽  
Zirconia Ceramic ◽  
Published Data ◽  
Clinical Use ◽  
Short Term ◽  
Tissue Integration ◽  
Meta Review ◽  
Ceramic Implants ◽  
Zirconia Implants

Abstract Purpose of Review The goal of the present review is to update the reader on the scientific background of zirconia ceramic implants. Clinical investigations using zirconia ceramic implants over the last couple of years have brought up some new developments and questions. Can we be confident in placing zirconia ceramic implants given the recently published data? Is there a difference in the application of one- and two-piece implants? Recent Findings Systematic reviews on preclinical investigations of zirconia implants revealed that one-piece zirconia implants (> 4 mm) are sufficiently stable for clinical use. The same is true for some clinically available two-piece implant systems. Osseointegration and soft tissue integration are, according to the reviews, similar between titanium and zirconia implants with similar surface topographies. Regarding the clinical outcome, a meta-review exists evaluating systematic reviews. The findings of the systematic reviews and the meta-review are that there are good short-term clinical results for one-piece zirconia implants. However, the data for two-piece implants is not robust. Summary In certain applications (single tooth restorations and small bridges), the results of zirconia implants are comparable with titanium implants in short-term studies. Some mid-term investigations support the short-term results. However, according to the current scientific data available, zirconia implants cannot yet be considered an alternative to titanium implants because there are many areas where there is a lack of clinical studies on zirconia implants. Currently, they are an addendum to the titanium implant armamentarium for situations where they are useful (patient request, known hypersensitivity to titanium, or questions of esthetics when titanium might appear inappropriate for a certain situation/condition), but long-term studies are needed. Without a doubt, there is a need for two-piece zirconia implants, but limited research exists to support their clinical use at the moment.

The experimental study of tissue integration into porous titanium implants

2020 ◽  
pp. 112070002094348
Author(s):  
Rashid Tikhilov ◽  
Igor Shubnyakov ◽  
Alexey Denisov ◽  
Vladimir Konev ◽  
Iosif Gofman ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Bone Defect ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Control Group ◽  
Additive Technology ◽  
Tissue Integration ◽  
3D Printed ◽  
Tissue Attachment ◽  
Highly Porous

Introduction: Due to a lack of uniform shapes and sizes of bone defects in hip and knee joint pathology, their fixing could benefit from using individually manufactured 3D-printed highly porous titanium implants. The objective of this study was to evaluate the extent of bone and muscle tissue integration into porous titanium implants manufactured using additive technology. Materials and methods: Porous and non-porous titanium plates were implanted into the latissimus dorsi muscle and tibia of 9 rabbits. On days 1, 60 and 90 animals were examined with x-rays. On day 60 histological tests were carried out. On day 90 the tensile strength at the implant-tissue interface was tested. Results: Histological analysis of muscle samples with porous titanium implants showed integration of connective tissue and blood vessels into the pores. Bone defect analysis demonstrated bone ingrowth into the pores of titanium with a minimal amount of fibrous tissue. The tensile strength of the muscular tissue attachment to the porous titanium was 28 (22–30) N which was higher than that of the control group 8.5 (5–11) N. Bone tissue attachment strength was 148 (140–152) N in the experimental group versus 118 (84–122) N in the control group. Conclusions: Using additive technology in manufacturing 3D-printed highly porous titanium implants improves bone and muscle integration compared with the non-porous material of the control group. This could be a promising approach to bone defect repair in revision and reconstruction surgery.

scholarly journals Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae

2021 ◽  
Vol 23 (1) ◽  
pp. 374
Author(s):  
Sabine Stoetzel ◽  
Deeksha Malhan ◽  
Ute Wild ◽  
Christian Helbing ◽  
Fathi Hassan ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Titanium Alloy ◽  
Hyaluronic Acid ◽  
Self Assembly ◽  
Bone Matrix ◽  
Preclinical Study ◽  
Titanium Implants ◽  
Layer By Layer ◽  
Bioactive Coatings ◽  
Bone Interface

Osseointegration is a prerequisite for the long-term success of implants. Titanium implants are preferred for their biocompatibility and mechanical properties. Nonetheless, the need for early and immediate loading requires enhancing these properties by adding bioactive coatings. In this preclinical study, extracellular matrix properties and cellular balance at the implant/bone interface was examined. Polyelectrolyte multilayers of chitosan and gelatin or with chitosan and Hyaluronic acid fabricated on titanium alloy using a layer-by-layer self-assembly process were compared with native titanium alloy. The study aimed to histologically evaluate bone parameters that correlate to the biomechanical anchorage enhancement resulted from bioactive coatings of titanium implants in a rat animal model. Superior collagen fiber arrangements and an increased number of active osteocytes reflected a significant improvement of bone matrix quality at the bone interface of the chitosan/gelatin-coated titan implants over chitosan/hyaluronic acid-coated and native implants. Furthermore, the numbers and localization of osteoblasts and osteoclasts in the reparative and remodeling phases suggested a better cellular balance in the chitosan/Gel-coated group over the other two groups. Investigating the micro-mechanical properties of bone tissue at the interface can elucidate detailed discrepancies between different promising bioactive coatings of titanium alloys to maximize their benefit in future medical applications.

scholarly journals BONE AND SOFT TISSUES INTEGRATION IN POROUS TITANIUM IMPLANTS (EXPERIMENTAL RESEARCH)

2018 ◽  
Vol 24 (2) ◽  
pp. 95-107 ◽  
Author(s):  
R. M. Tikhilov ◽  
I. I. Shubnyakov ◽  
A. O. Denisov ◽  
V. A. Konev ◽  
I. V. Gofman ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Latissimus Dorsi ◽  
Fibrous Tissue ◽  
Porous Titanium ◽  
Additive Technologies ◽  
Titanium Implants ◽  
Knee Joints ◽  
Control Group ◽  
Muscular Tissue ◽  
Tissue Integration

Aim. It’s common that revision arthroplasty of the large joints demands replacing of bone defects of irregular geometrical shapes and simultaneous restoring of support ability and ability to integrate surrounding muscular and tendinous structures into an implant that is required for a complete restoration of joint function.The purpose.To experimentally study the process of integration for muscular and bone tissue as well as tendinous and ligamentous structures into porous titanium materials.Material and methods. During in vivo experiment the authors created a standardized bone defect in 6 rabbits of chinchilla breed at the point of patella ligament attachment as well as a delamination area of muscular tissue in latissimus dorsi. Both knee joints and both latissimus dorsi were used in each animal. Study group included titanium implants with three-dimensional mesh structure. Control group — solid titanium implants with standard porosity. Titanium implants were produced by additive technologies with preliminary prototyping. The porosity corresponded to trabecular metal, striations — 0.45, pores size —100–200 microns. Study and control components were implanted in the identical conditions into the corresponding anatomical sites. Postoperative AP and lateral roentgenograms of knee joints were performed for all animals. Morphological research was conducted on day 60 after the implantation and strength properties were studied at day 90 after the implantation.Results.The authors observed bony ingrowth into implant pores with minimal volume of fibrous tissue, a distinct connective integration was reported represented by a dense fibrous tissue in the pores of components implanted into the muscular tissue. Testing of fixation strength of the study implants demonstrated a clearly superior strength of soft and bone tissue integration into the experimental mesh implants produced using additive technologies.

Orchestrating soft tissue integration at the transmucosal region of titanium implants

2021 ◽  
Author(s):  
Tianqi Guo ◽  
Karan Gulati ◽  
Himanshu Arora ◽  
Pingping Han ◽  
Benjamin Fournier ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Titanium Implants ◽  
Tissue Integration

scholarly journals Influence of Bioinspired Lithium-Doped Titanium Implants on Gingival Fibroblast Bioactivity and Biofilm Adhesion

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2799
Author(s):  
Aya Q. Alali ◽  
Abdalla Abdal-hay ◽  
Karan Gulati ◽  
Sašo Ivanovski ◽  
Benjamin P. J. Fournier ◽  
...  
Keyword(s):  
Dental Implants ◽  
Metabolic Activity ◽  
Matrix Protein ◽  
Clinical Importance ◽  
Titanium Implants ◽  
Extracellular Matrix Protein ◽  
Gingival Fibroblast ◽  
Mrna Levels ◽  
Tissue Integration

Soft tissue integration (STI) at the transmucosal level around dental implants is crucial for the long-term success of dental implants. Surface modification of titanium dental implants could be an effective way to enhance peri-implant STI. The present study aimed to investigate the effect of bioinspired lithium (Li)-doped Ti surface on the behaviour of human gingival fibroblasts (HGFs) and oral biofilm in vitro. HGFs were cultured on various Ti surfaces—Li-doped Ti (Li_Ti), NaOH_Ti and micro-rough Ti (Control_Ti)—and were evaluated for viability, adhesion, extracellular matrix protein expression and cytokine secretion. Furthermore, single species bacteria (Staphylococcus aureus) and multi-species oral biofilms from saliva were cultured on each surface and assessed for viability and metabolic activity. The results show that both Li_Ti and NaOH_Ti significantly increased the proliferation of HGFs compared to the control. Fibroblast growth factor-2 (FGF-2) mRNA levels were significantly increased on Li_Ti and NaOH_Ti at day 7. Moreover, Li_Ti upregulated COL-I and fibronectin gene expression compared to the NaOH_Ti. A significant decrease in bacterial metabolic activity was detected for both the Li_Ti and NaOH_Ti surfaces. Together, these results suggest that bioinspired Li-doped Ti promotes HGF bioactivity while suppressing bacterial adhesion and growth. This is of clinical importance regarding STI improvement during the maintenance phase of the dental implant treatment.

scholarly journals Nanoparticles and Nanostructured Surface Fabrication for Innovative Cranial and Maxillofacial Surgery

Materials ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 5391
Author(s):  
Simona Cavalu ◽  
Iulian Vasile Antoniac ◽  
Aurel Mohan ◽  
Florian Bodog ◽  
Cristian Doicin ◽  
...  
Keyword(s):  
Bulk Material ◽  
Maxillofacial Surgery ◽  
Titanium Implants ◽  
Tissue Integration ◽  
Cranial Implant ◽  
Flexible Adaptation ◽  
Novel Strategy ◽  
Surface Fabrication ◽  
Modification Of Titanium ◽  
Physical And Chemical

A novel strategy to improve the success of soft and hard tissue integration of titanium implants is the use of nanoparticles coatings made from basically any type of biocompatible substance, which can advantageously enhance the properties of the material, as compared to its similar bulk material. So, most of the physical methods approaches involve the compaction of nanoparticles versus micron-level particles to yield surfaces with nanoscale grain boundaries, simultaneously preserving the chemistry of the surface among different topographies. At the same time, nanoparticles have been known as one of the most effective antibacterial agents and can be used as effective growth inhibitors of various microorganisms as an alternative to antibiotics. In this paper, based on literature research, we present a comprehensive review of the mechanical, physical, and chemical methods for creating nano-structured titanium surfaces along with the main nanoparticles used for the surface modification of titanium implants, the fabrication methods, their main features, and the purpose of use. We also present two patented solutions which involve nanoparticles to be used in cranioplasty, i.e., a cranial endoprosthesis with a sliding system to repair the traumatic defects of the skull, and a cranial implant based on titanium mesh with osteointegrating structures and functional nanoparticles. The main outcomes of the patented solutions are: (a) a novel geometry of the implant that allow both flexible adaptation of the implant to the specific anatomy of the patient and the promotion of regeneration of the bone tissue; (b) porous structure and favorable geometry for the absorption of impregnated active substances and cells proliferation; (c) the new implant model fit 100% on the structure of the cranial defect without inducing mechanical stress; (d) allows all kinds of radiological examinations and rapid osteointegration, along with the patient recover in a shorter time.

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