Decreased Interleukin-1β and Elastase in the Gingival Crevicular Fluid of Individuals Undergoing Anti-Inflammatory Treatment for Rheumatoid Arthritis

2007 ◽  
Vol 78 (8) ◽  
pp. 1612-1619 ◽  
Author(s):  
Letícia A. Miranda ◽  
Alexandre G. Islabão ◽  
Ricardo G. Fischer ◽  
Carlos M.S. Figueredo ◽  
Rui V. Oppermann ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gingival Crevicular Fluid ◽  
Interleukin 1Β ◽  
Anti Inflammatory ◽  
Crevicular Fluid

Interleukin-1β Concentration of Gingival Crevicular Fluid

1994 ◽  
Vol 65 (5) ◽  
pp. 423-428 ◽  
Author(s):  
Dagmar S. Preiss ◽  
Joerg Meyle
Keyword(s):  
Gingival Crevicular Fluid ◽  
Interleukin 1Β ◽  
Crevicular Fluid

scholarly journals Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

2019 ◽  
Vol 8 (5) ◽  
pp. 630 ◽  
Author(s):  
Kaja Eriksson ◽  
Guozhong Fei ◽  
Anna Lundmark ◽  
Daniel Benchimol ◽  
Linkiat Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Mediators ◽  
Gingival Crevicular Fluid ◽  
Severe Form ◽  
Oral Microbiota ◽  
Microbial Composition ◽  
Periodontal Health ◽  
Microbial Profile ◽  
Severe Periodontitis ◽  
Crevicular Fluid

This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-α2, IL-19, IL-26, MMP-1, gp130/sIL-6Rß, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.

Increased Interleukin-1β Concentration in Gingival Crevicular Fluid as a Characteristic of Periodontitis

1999 ◽  
Vol 70 (12) ◽  
pp. 1457-1463 ◽  
Author(s):  
C.M.S. Figueredo ◽  
M.S.M. Ribeiro ◽  
R.G. Fischer ◽  
A. Gustafsson
Keyword(s):  
Gingival Crevicular Fluid ◽  
Interleukin 1Β ◽  
Crevicular Fluid

Gingival Crevicular Fluid MMP-8 and -13 and TIMP-1 Levels in Patients With Rheumatoid Arthritis and Inflammatory Periodontal Disease

2009 ◽  
Vol 80 (8) ◽  
pp. 1307-1314 ◽  
Author(s):  
Başak Bıyıkoğlu ◽  
Nurcan Buduneli ◽  
Levent Kardeşler ◽  
Kenan Aksu ◽  
Marjut Pitkala ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Crevicular Fluid

scholarly journals Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Isabela Silosi ◽  
Manole Cojocaru ◽  
Lili Foia ◽  
Mihail Virgil Boldeanu ◽  
Florin Petrescu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Serum Levels ◽  
Joint Disease ◽  
Control Serum ◽  
Healthy Control ◽  
Crevicular Fluid ◽  
And Control ◽  
Metalloproteinase 9

In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP. A total of fifty-six patients were included in the study. The subjects were categorized into four groups as follows: healthy-control (n=21), active RA (n=16), CP (n=14), and RA-CP association (n=12). Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique. The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control. Serum levels of MMP-9 were similar in RA and RA-CP associated patients. Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP. Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association. MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.

scholarly journals Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Zaira F. Kharaeva ◽  
Lyana R. Zhanimova ◽  
Magomet Sh. Mustafaev ◽  
Chiara De Luca ◽  
Wolfgang Mayer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gingival Crevicular Fluid ◽  
Clinical Symptoms ◽  
Topical Administration ◽  
Control Group ◽  
Pocket Depth ◽  
Bacterial Killing ◽  
Anti Inflammatory ◽  
Nitric Oxide Metabolites ◽  
Crevicular Fluid

The clinical efficacy of topical administration of standardised fermented papaya gel (SFPG), known to have antioxidant and anti-inflammatory properties,versusconventional therapy was evaluated in a group of 84 patients with moderate-to-severe periodontitis, randomly assigned to control group (n=45) undergoing traditional pharmacologic/surgical protocols or to experimental group (n=39), additionally treated with intragingival pocket SFPG (7 g) applications (15 min daily for 10 days). Patients undergoing SFPG treatment showed significant (P<0.05), durable improvement of three major clinical indices of disease severity: reduced bleeding (day 7), plaque and gingival conditions (day 14), and consistent gingival pocket depth reduction (day 45). Proinflammatory nitric oxide metabolites reached normal values in plasma (day 14) and gingival crevicular fluid (GCF) at day 45 with SFPG applications compared to controls that did not reach normalisation. Levels of highly increased proinflammatory (IL-1B, IL-6) and suppressed anti-inflammatory (IL-10) cytokines normalised in the SFPG group by days 14 (plasma) and 45 (GCF), but never in the control group. Although not acting directly as antibiotic, SFPG acted in synergy with human granulocytes blocking adaptive catalase induction inS. aureusin response to granulocyte-derived oxidative stress, thus enhancing intracellular bacterial killing.

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