scholarly journals Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Isabela Silosi ◽  
Manole Cojocaru ◽  
Lili Foia ◽  
Mihail Virgil Boldeanu ◽  
Florin Petrescu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Serum Levels ◽  
Joint Disease ◽  
Control Serum ◽  
Healthy Control ◽  
Crevicular Fluid ◽  
And Control ◽  
Metalloproteinase 9

In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP. A total of fifty-six patients were included in the study. The subjects were categorized into four groups as follows: healthy-control (n=21), active RA (n=16), CP (n=14), and RA-CP association (n=12). Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique. The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control. Serum levels of MMP-9 were similar in RA and RA-CP associated patients. Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP. Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association. MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.

Study on the TNF-a, Il-1b and Il-6 Levels in Patients with Chronic Periodontitis and Cardiovascular Diseases

2017 ◽  
Vol 68 (3) ◽  
pp. 619-623
Author(s):  
Ovidiu Nicolaiciuc ◽  
Constantin Mihai ◽  
Irina Georgeta Sufaru ◽  
Ioana Martu ◽  
Sorina Mihaela Solomon ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Healthy Subjects ◽  
Gingival Crevicular Fluid ◽  
Control Group ◽  
Beneficial Effects ◽  
Statin Group ◽  
Crevicular Fluid ◽  
Inflammatory Molecules ◽  
And Control ◽  
Pro Inflammatory Cytokines

Studies on the link between periodontal disease and atherosclerosis have generated conflicting results and the mechanisms underlying this relationship are incompletely understood. Therefore, this study aimed to assess the levels in serum and in gingival crevicular fluid (GCF) of TNF-a, IL-1b and IL-6, to clarify the possible link between periodontitis and hyperlipidemia, as well as the effects of conventional periodontal treatment through scaling and root surfacing on these pro-inflammatory molecules. The study was carried out on a total of 40 subjects divided into two main groups: the study group (n=26) and control group (n=14). The cases included patients with atherosclerosis with prescribed diet (D) or antilipemic therapy with a drug from the statin group (S). Controls (C) were selected from systemically healthy subjects with chronic periodontitis. Samples were performed from crevicular fluid and serum, by determining the initial and post-treatment of TNF-a, IL-1b and IL-6. For all groups there were significant serum decreases in TNF-a, IL-1b and IL-6 from baseline, and the decreases were more significant IL-1b for statin group. Significant decreases were found in the crevicular fluid for all cytokines. The decrease was most evident for IL-6 in the statin group. Combining antilipemic periodontal therapy and treatment can provide beneficial effects on metabolism and control of inflammatory atherosclerosis by lowering serum pro-inflammatory cytokines.

scholarly journals Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Eiju Shimizu ◽  
Tetsuo Kobayashi ◽  
Hiroyuki Wakabayashi ◽  
Koji Yamauchi ◽  
Keiji Iwatsuki ◽  
...  
Keyword(s):  
Oral Administration ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Test Group ◽  
Control Group ◽  
Control Groups ◽  
Bacteriological Profile ◽  
Crevicular Fluid ◽  
And Control ◽  
Parameter Values

This study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group,n=37) or control tablets (control group,n=35) every day for 12 weeks. Periodontal parameters and levels of subgingival plaque bacteria, human and bovine LF, and endotoxin in gingival crevicular fluid (GCF) were evaluated at baseline, 1 week, 4 weeks, and 12 weeks. Significant differences were observed in GCF levels of bovine LF between the test and control groups throughout the study (P<.05). However, clinical and bacteriological parameter values proved comparable between the two groups at 1 week to 12 weeks. Therefore, the effect of oral administration of LF and LPO-containing tablets might be weak on periodontal and bacteriological profile in this study.

Gingival crevicular fluid and serum levels of APRIL, BAFF and TNF-alpha in rheumatoid arthritis and osteoporosis patients with periodontal disease

2013 ◽  
Vol 58 (10) ◽  
pp. 1302-1308 ◽  
Author(s):  
Pınar Gümüş ◽  
Eralp Buduneli ◽  
Başak Bıyıkoğlu ◽  
Kenan Aksu ◽  
Fulden Saraç ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Serum Levels ◽  
Tnf Alpha ◽  
Crevicular Fluid

Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis

2013 ◽  
Vol 5 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Fawad Javed ◽  
Hameeda B. Ahmed ◽  
Toshinari Mikami ◽  
Khalid Almas ◽  
Georgios E. Romanos ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Cytokine Profile ◽  
Crevicular Fluid

Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients

2013 ◽  
Vol 33 (10) ◽  
pp. 2607-2616 ◽  
Author(s):  
Başak Bıyıkoğlu ◽  
Nurcan Buduneli ◽  
Kenan Aksu ◽  
Ayşe Nalbantsoy ◽  
David F. Lappin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Interleukin 1Beta ◽  
Crevicular Fluid
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