Early Cellular Responses in Cortical Bone Healing Around Unloaded Titanium Implants: An Animal Study

2006 ◽  
Vol 77 (6) ◽  
pp. 1015-1024 ◽  
Author(s):  
Elke Slaets ◽  
Geert Carmeliet ◽  
Ignace Naert ◽  
Joke Duyck
Keyword(s):  
Cortical Bone ◽  
Animal Study ◽  
Bone Healing ◽  
Cellular Responses ◽  
Titanium Implants

Thyroid Hormones May Influence Cortical Bone Healing Around Titanium Implants: A Histometric Study in Rats

2008 ◽  
Vol 79 (5) ◽  
pp. 881-887 ◽  
Author(s):  
Daniela da Silva Feitosa ◽  
Beatriz de Brito Bezerra ◽  
Gláucia Maria Bovi Ambrosano ◽  
Francisco Humberto Nociti ◽  
Márcio Zaffalon Casati ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cortical Bone ◽  
Bone Healing ◽  
Titanium Implants

Early cortical bone healing around loaded titanium implants: a histological study in the rabbit

2009 ◽  
Vol 20 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Elke Slaets ◽  
Ignace Naert ◽  
Geert Carmeliet ◽  
Joke Duyck
Keyword(s):  
Cortical Bone ◽  
Bone Healing ◽  
Histological Study ◽  
Titanium Implants

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

scholarly journals Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Raluca M. Boteanu ◽  
Viorel I. Suica ◽  
Luminita Ivan ◽  
Florentina Safciuc ◽  
Elena Uyy ◽  
...  
Keyword(s):  
Bone Healing ◽  
Cultured Cells ◽  
Traumatic Event ◽  
Healing Process ◽  
Dip Coating ◽  
Polymer Coatings ◽  
Titanium Implants ◽  
Mass Spectrometry Analysis ◽  
Defect Model ◽  
Tibial Defect

Abstract Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing becomes a clinical problem and affects the patient's quality of life. We aimed to design a new bioactive surface of titanium implants with a synergetic PEG biopolymer-based composition for gradual delivery of growth factors (FGF2, VEGF, and BMP4) during bone healing. The optimal architecture of non-cytotoxic polymeric coatings deposited by dip coating under controlled parameters was assessed both in cultured cells and in a rat tibial defect model (100% viability). Notably, the titanium adsorbed polymer matrix induced an improved healing process when compared with the individual action of each biomolecules. High-performance mass spectrometry analysis demonstrated that recovery after a traumatic event is governed by specific differentially regulated proteins, acting in a coordinated response to the external stimulus. Predicted protein interactions shown by STRING analysis were well organized in hub-based networks related with response to chemical, wound healing and response to stress pathways. The proposed functional polymer coatings of the titanium implants demonstrated the significant improvement of bone healing process after injury.

Mechanical and histomorphometric evaluations of titanium implants with different surface treatments inserted in sheep cortical bone

Biomaterials ◽  
2003 ◽  
Vol 24 (9) ◽  
pp. 1583-1594 ◽  
Author(s):  
Gianluca Giavaresi ◽  
Milena Fini ◽  
Alberto Cigada ◽  
Roberto Chiesa ◽  
Gianni Rondelli ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Surface Treatments ◽  
Titanium Implants

Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice

2016 ◽  
Vol 125 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Xiaofei Zheng ◽  
Anchun Mo ◽  
Yuan Wang ◽  
Yuchen Guo ◽  
Yunshu Wu ◽  
...  
Keyword(s):  
Bone Healing ◽  
Biomechanical Study ◽  
Titanium Implants ◽  
Fk 506 ◽  
Tacrolimus Therapy

The Effect of Novel Flax Oil-Based Implant Coating on Bone Healing Process (In Vivo Animal Study)

2015 ◽  
Vol 119 (3) ◽  
pp. e126
Author(s):  
Nazih Shaaban Mustafa ◽  
Basma E. Mustafa Al Ahmad ◽  
Ammar A. Mustafa ◽  
Muhannad A. Kashmoola
Keyword(s):  
Animal Study ◽  
Bone Healing ◽  
Healing Process ◽  
Flax Oil ◽  
Implant Coating ◽  
Bone Healing Process

Histology and stability study of cortical bone graft influence on titanium implants

2007 ◽  
Vol 103 (4) ◽  
pp. e1-e7 ◽  
Author(s):  
Giacomo De Riu ◽  
Nicola De Riu ◽  
Giovanni Spano ◽  
Angelo Pizzigallo ◽  
Giovanna Petrone ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Bone ◽  
Stability Study ◽  
Titanium Implants ◽  
Cortical Bone Graft

High-throughput gene expression analysis in bone healing around titanium implants by DNA microarray

2008 ◽  
Vol 19 (2) ◽  
pp. 173-181 ◽  
Author(s):  
Norinaga Kojima ◽  
Shogo Ozawa ◽  
Yasuhiro Miyata ◽  
Hideki Hasegawa ◽  
Yoshinobu Tanaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Microarray ◽  
Expression Analysis ◽  
High Throughput ◽  
Bone Healing ◽  
Gene Expression Analysis ◽  
Titanium Implants ◽  
High Throughput Gene Expression
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