A Histochemical Investigation of the Bone Formation Process by Guided Bone Regeneration in Rat Jaws. Effect of PTFE Membrane Application Periods on Newly Formed Bone

2000 ◽  
Vol 71 (3) ◽  
pp. 341-352 ◽  
Author(s):  
Hideo Ohnishi ◽  
Noritaka Fujii ◽  
Takayuki Futami ◽  
Naoyuki Taguchi ◽  
Haruka Kusakari ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Formation Process ◽  
Guided Bone Regeneration ◽  
Histochemical Investigation ◽  
Ptfe Membrane

scholarly journals Digital Customized Titanium Mesh for Bone Regeneration of Vertical, Horizontal and Combined Defects: A Case Series

Medicina ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 60
Author(s):  
Daniele De Santis ◽  
Federico Gelpi ◽  
Giuseppe Verlato ◽  
Umberto Luciano ◽  
Lorena Torroni ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Case Series ◽  
Guided Bone Regeneration ◽  
Point Of View ◽  
Significant Gain ◽  
Titanium Mesh ◽  
New Bone Formation ◽  
Correct Method ◽  
Combined Defects

Background and Objective: Guided bone regeneration allows new bone formation in anatomical sites showing defects preventing implant rehabilitation. Material and Methods: The present case series reported the outcomes of five patients treated with customized titanium meshes manufactured with a digital workflow for achieving bone regeneration at future implant sites. A significant gain in both width and thickness was achieved for all patients. Results: From a radiographic point of view (CBTC), satisfactory results were reached both in horizontal and vertical defects. An average horizontal gain of 3.6 ± 0.8 mm and a vertical gain of 5.2 ± 1.1 mm. Conclusions: The findings from this study suggest that customized titanium meshes represent a valid method to pursue guided bone regeneration in horizontal, vertical or combined defects. Particular attention must be paid by the surgeon in the packaging of the flap according to a correct method called the “poncho” technique in order to reduce the most frequent complication that is the exposure of the mesh even if a partial exposure of one mesh does not compromise the final outcome of both the reconstruction and the healing of the implants.

scholarly journals Vertical Guided Bone Regeneration using Titanium-reinforced d-PTFE Membrane and Prehydrated Corticocancellous Bone Graft

2014 ◽  
Vol 8 (1) ◽  
pp. 194-200 ◽  
Author(s):  
Alessandro Cucchi ◽  
Paolo Ghensi
Keyword(s):  
Bone Regeneration ◽  
Histological Analysis ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Allogeneic Bone ◽  
Present Case Report ◽  
Ptfe Membrane ◽  
Bone Particles ◽  
Functional Loading

Guided bone regeneration (GBR) standard protocols call for filling the space underneath the membrane with autogenous bone or a mixture composed of autogenous bone particles and allogeneic bone tissue or heterologous biomaterials. This work describes the case of a GBR performed to restore a vertical bone defect with simultaneous placement of a dental implant in the posterior mandible that was carried out using a high density d-PTFE membrane and corticocancellous porcine-derived bone without the addition of any autogenous bone. Bone regeneration was assessed by histological analysis of a biopsy sample collected from the grafted site nine months after the surgery. Intraoral radiographs taken at follow-up visits showed complete maintenance of the peri-implant bone levels for up to two years after prosthesis delivery. The regenerated site successfully supported functional loading of the implant. The present case report suggests that the use of a heterologous bone substitute alone to restore a vertical defect in a GBR procedure can be as effective as the standard protocol, while avoiding the drawbacks associated with a second surgical site opening.

scholarly journals Porcine Collagen–Bone Composite Induced Osteoblast Differentiation and Bone Regeneration In Vitro and In Vivo

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 93 ◽  
Author(s):  
Eisner Salamanca ◽  
Chia Chen Hsu ◽  
Wan Ling Yao ◽  
Cheuk Sing Choy ◽  
Yu Hwa Pan ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Osteoblast Differentiation ◽  
Critical Size ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Critical Size Defects ◽  
Bone Formation Markers

Due to autogenous bone limitations, some substitute bone grafts were developed. Collagenated porcine graft (CPG) is able to regenerate new bone, although the number of studies is insufficient, highlighting the need for future studies to better understand the biomaterial. In order to understand better CPG′s possible dental guided bone regeneration indications, the aim of this work was to determine CPG′s biological capacity to induce osteoblast differentiation in vitro and guided bone regeneration in vivo, whilst being compared with commercial hydroxyapatite and beta tricalcium phosphate (HA/β-TCP) and porcine graft alone. Cell cytotoxicity (WST-1), alkaline phosphatase activity (ALP), and real-time polymerase chain reaction (qPCR) were assessed in vitro. Critical size defects of New Zealand white rabbits were used for the in vivo part, with critical size defect closures and histological analyses. WST-1 and ALP indicated that CPG directly stimulated a greater proliferation and confluency of cells with osteoblastic differentiation in vitro. Gene sequencing indicated stable bone formation markers, decreased resorption makers, and bone remodeling coupling factors, making the transition from osteoclast to osteoblast expression at the end of seven days. CPG resulted in the highest new bone regeneration by osteoconduction in critical size defects of rabbit calvaria at eight weeks. Nonetheless, all biomaterials achieved nearly complete calvaria defect closure. CPG was found to be osteoconductive, like porcine graft and HA/β-TCP, but with higher new bone formation in critical size defects of rabbit calvaria at eight weeks. CPG can be used for different dental guided bone regeneration procedures; however, further studies are necessary.

Guided Bone Regeneration, Platelet Rich Plasma and Low-Intensity Ultrasound Irradiation for Dental Implants

2006 ◽  
Vol 49 ◽  
pp. 171-180 ◽  
Author(s):  
Kuniteru Nagahara ◽  
Toshiichiro Tanabe ◽  
Noriaki Ito ◽  
Motohiko Nagayama ◽  
Kota Takagi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Dental Implant ◽  
Platelet Rich Plasma ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Bone Block ◽  
Bone Augmentation ◽  
Basic Study ◽  
Low Intensity

Because a concept of an osteointegrated dental implant system was established, prognosis of a dental implant at treatment improved and the treatment of restoration for missing teeth was changed. However, a dental implant treatment into atrophic jaw bone requires bone augmentation, obviously. At this time, we studied for the purpose of establishing the evidence of each method for clinical application of these bone augmentation method, such as guided bone regeneration (GBR), and autogenous bone block graft (BBG). In addition, we pursued the basic study of the evidence about the bone formation with platelet rich plasma (PRP) which recognized the availability in clinic. Furthermore, we present the results of basic studies which we tested for the purpose of applying a low-intensity pulse ultrasound (LIPU) irradiation applied to a fracture treatment in orthopedics area to intra-oral area, specially the condition after implant placement. In the results of comparison with GBR site and BBG, the differences of labeling bands were observed with a fluorescence microscopy. There was much labeling bands on GBR sections in comparison with BBG. This meaning that the bone remodeling around implants at GBR site was more active than BBG site. And the new bone formation by PRP was identified on soft X-ray graphically at first week after PRP applied mandible bone defect (experimental side). At same region of first week specimen, we confirmed positive reactions of platelet derived growth factor

Comparison of the performance of natural latex membranes prepared with different procedures and PTFE membrane in guided bone regeneration (GBR) in rabbits

2014 ◽  
Vol 25 (9) ◽  
pp. 2111-2120 ◽  
Author(s):  
Jonas M. L. Moura ◽  
Juliana F. Ferreira ◽  
Leonardo Marques ◽  
Leandro Holgado ◽  
Carlos F. O. Graeff ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Ptfe Membrane

Study on Formation Process of Cell-Containing Guided Bone Regeneration Membrane

2018 ◽  
Vol 8 (10) ◽  
pp. 1420-1428
Author(s):  
Haiping Chen ◽  
Jun Ji ◽  
Surong Wu ◽  
Xia Wu ◽  
Weidong Pan ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Formation Process ◽  
Guided Bone Regeneration

scholarly journals Use of a gelatin hydrogel membrane containing β-tricalcium phosphate for guided bone regeneration enhances rapid bone formation

2014 ◽  
Vol 33 (5) ◽  
pp. 674-680 ◽  
Author(s):  
Kanako NORITAKE ◽  
Shinji KURODA ◽  
Myat NYAN ◽  
Yuji ATSUZAWA ◽  
Motohiro UO ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Guided Bone Regeneration ◽  
Gelatin Hydrogel ◽  
Hydrogel Membrane
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