Comparison between acute effects of intermittent hypoxia and aerobic exercise on nitric oxide level, blood pressure and lung function in apnea

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaowen Jia ◽  
Rong Zhang ◽  
Jinzhu Guo ◽  
Hua Yue ◽  
Qiuxia Liu ◽  
...  

Background. Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model. Methods. Forty female Sprague Dawley (SD) rats were randomized into 4 groups: Normal Preg (0.9% salt diet), Normal Preg + RES (0.9% salt diet plus daily oral RES for 4 weeks), Salt Preg (8% salt diet), and Salt Preg + RES (8% salt diet plus daily oral RES for 4 weeks). Noninvasive blood pressure was recorded on gestational days 7 and 14. On the gestational day 19, foetuses were weighed, and blood and urine samples were harvested for electrolytes and biochemical assays. Results. RES significantly reduced SBP, DBP, and MAP on gestational days 7 and 14 in the Salt Preg + RES group compared to the Salt Preg group (all P<0.05). Compared to the Salt Preg group, the foetal weight, serum NO level, urinary sodium, and 24 hour urine volume were significantly increased in the Salt Preg + RES group (all P<0.05). On the contrary, the levels of serum urea, serum creatinine, and urinary protein were significantly decreased in the Salt Preg + RES group compared to the Salt Preg group (all P<0.05). Conclusions. RES decreases blood pressure in a hypertensive pregnant rat model. Increasing sodium excretion and serum nitric oxide level might be, at least part of, the underlying mechanisms.


2009 ◽  
Vol 133 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Emmanuel G. Ciolac ◽  
Guilherme V. Guimarães ◽  
Veridiana M. D´Àvila ◽  
Luiz A. Bortolotto ◽  
Egidio L. Doria ◽  
...  

2012 ◽  
Vol 60 (36) ◽  
pp. 9130-9136 ◽  
Author(s):  
Aidilla Mubarak ◽  
Catherine P. Bondonno ◽  
Alex H. Liu ◽  
Michael J. Considine ◽  
Lisa Rich ◽  
...  

2021 ◽  
pp. 1-7
Author(s):  
Francini Porcher Andrade ◽  
Talmir Nolasco ◽  
Marli Maria Knorst ◽  
Paula Maria Eidt Rovedder

<b><i>Introduction:</i></b> A healthy arteriovenous fistula (AVF) depends on adequate vessel diameter which can be maintained through aerobic exercises. A randomized crossover study was conducted to evaluate the acute effects of aerobic exercise on a cycle ergometer on AVF vascular diameter, through ultrasound, and on blood pressure (BP). <b><i>Methods:</i></b> Eight hemodialysis (HD) patients completed 2 different occasions in random order with a 7-day washout: (a) exercising moment, in which 30-min aerobic exercise was performed on a cycle ergometer; and (b) resting moment, which was performed 30-min with the patient sitting in a chair. Both occasions were evaluated 1-h before the second weekly HD day. <b><i>Results:</i></b> A significant increase in AVF vascular diameter induced by 30-min aerobic exercise was found (1.15 ± 0.56 to 1.47 ± 0.66 cm; <i>p</i> = 0.042), whereas systolic (<i>p</i> = 0.105) and diastolic BP (<i>p</i> = 0.366) did not change. <b><i>Conclusions:</i></b> We can conclude that acute aerobic exercise was shown to be effective in improving the AVF vascular diameter in HD patients. The aerobic exercise benefits in endothelium-dependent vasodilation which may be an effective, practical, and economic strategy to maintain AVF patency.


Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2755
Author(s):  
Yoko Yamashita ◽  
Asuka Nakamura ◽  
Fumio Nanba ◽  
Shizuka Saito ◽  
Toshiya Toda ◽  
...  

Vascular dysfunction and injurious stimuli such as oxidative stress are closely related to the risk of cardiovascular diseases (CVD). Dietary polyphenols are reported to exert beneficial effects in reducing the risk of CVD. Black soybean has been used as a nutritionally rich food and contains abundant polyphenols in its seed coat and grain. Black soybean has many beneficial physiological activities, and its prevention effects on CVD risk were reported mainly in animal experiments. In this study, we performed a randomized, single blind, placebo controlled, crossover trial to investigate the effect of black soybean consumption on the vascular function in healthy humans. Twenty-two healthy adults aged from 30 to 60 completed the four week trial with daily consumption of about a 40 g test material cookie containing 20 g roasted black soybean powder. Body composition, vascular function, biomarkers for oxidative stress, and polyphenol contents in the urine and the plasma were measured. After ingestion of the black soybean cookie, vascular function, which was evaluated by plethysmogram using a Pulse Analyzer®, was improved and systolic blood pressure was decreased. Moreover, nitric oxide levels in plasma and urine were increased, while an oxidative stress biomarker, 8-hydroxy-2′-deoxyguanosine level, in the plasma was decreased accompanied by an increase in the concentration of polyphenols derived from black soybean in plasma and urine. These results suggest that the antioxidant activity of black soybean polyphenols and an increase in the nitric oxide level may contribute to the improvement of vascular function. Thus, black soybean is an attractive food material for improvement of vascular function through decreasing oxidative stress by its potent antioxidant activity and increasing the nitric oxide level in healthy humans.


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