scholarly journals Coconut Oil Promotes Greater Satiety and Reduces Blood Cholesterol, But Induces Obesity, Anxiety and Impaired Bone Formation in Adult Wistar Rats

2021 ◽  
Author(s):  
Ítalo Gomes Reis ◽  
Arthur Rocha-Gomes ◽  
Alexandre Alves da Silva ◽  
Mayara Rodrigues Lessa ◽  
Nísia Andrade Villela Dessimoni Pinto ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Caloric Intake ◽  
Coconut Oil ◽  
Blood Cholesterol ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Total Blood ◽  
Beneficial Effects ◽  
To Receive ◽  
Tibia Length

Background: The aim of this study was to evaluate the nutritional effects of supplementation with virgin coconut oil (VCO) in Wistar rats over a sub-chronic period (6 weeks).Methods: Twelve Wistar rats were used and randomly assigned to receive (n = 6): control - lab chow; coconut oil (CO) - lab chow with added virgin coconut oil (20%). Food and caloric intake, weight gain, food efficiency, body mass index, femur and tibia length, bone mineral composition and blood biochemistry were evaluated.Result: The CO group showed an energy intake closed to control group. Also, the supplementation with VCO generated a decrease in total blood cholesterol as compared to the control group. However, the CO group showed accumulation of fat mass, shorter femur length and anxiogenesis in relation to the control group. These results indicate few beneficial effects from the sub-chronic use of VCO and indicate that its consumption in large quantities for long periods should be questioned.

scholarly journals Uji efek ekstrak biji alpukat (Persea americana Mill.) terhadap kadar kolesterol total pada tikus wistar (Rattus norvegicus)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Abraham T. Suhendra ◽  
Henoch Awaloei ◽  
Jane Wuisan
Keyword(s):  
Traditional Medicine ◽  
Wistar Rats ◽  
Seed Extract ◽  
Persea Americana ◽  
Blood Cholesterol ◽  
Control Group ◽  
Tropical Country ◽  
Total Blood ◽  
Total Blood Cholesterol ◽  
Avocado Seed

Abstract: Indonesia is a tropical country that has more than 1,000 kinds of medicinal plants. Medicinal plant is the use of part(s) of plants as ingredients in traditional medicine or synthetic drugs. One of the traditional medicine is avocado. Several studies have concluded that the avocado fruit and leaves can reduce total blood cholesterol levels while the seed is used in Nigeria for treating hypertension. This was an experimental study. Samples consisted of 12 male Wistar rats, divided into 4 groups (3 rats in each group). The treated groups were given propylthiouracil (PTU) for 14 days then the rats were given 125 mg/kg or 250 mg/kg of avocado seed extract for 14 days. The positive control group was given PTU 8 mg/rat for 14 days, followed by simvastatin 0.2 mg for 14 days. The negative control group was only given food and water. The results showed that the average level of total blood cholesterol in Wistar rats after treated with 125 mg/kg and 250 mg/kg avocado seed extract decreased by 18.1% and 31.2%, respectively. Conclusion: Avocado seed extract had an effect in reducing total blood cholesterol of Wistar rats.Keywords: avocado seed, total cholesterol levelAbstrak: Indonesia merupakan salah satu negara tropis yang memiliki banyak tumbuhan dimana lebih dari 1000 tumbuhan tersebut dapat digunakan sebagai tanaman obat. Tanaman obat ialah penggunaan bagian dari tanaman atau tumbuhan sebagai bahan dalam pembuatan obat tradisional maupun obat sintetik. Salah satu tanaman yang digunakan sebagai obat tradisional ialah alpukat. Beberapa penelitian mengenai tanaman alpukat menunjukkan bahwa buah dan daun dari tanaman Alpukat dapat menurunkan total kolesterol dalam darah, sedangkan biji alpukat digunakan di Nigeria sebagai pengobatan untuk hipertensi. Penelitian ini menggunakan metode eksperimental. Sampel ialah 12 ekor tikus Wistar jantan yang dibagi menjadi 4 kelompok (setiap kelompok terdiri dari 3 tikus). Kelompok-kelompok perlakuan diberikan propiltiourasil (PTU) selama 14 hari kemudian diberikan 125 mg/kg atau 250 mg/kg ekstrak biji Alpukat selama 14 hari. Kelompok kontrol positif diberikan PTU selama 14 hari kemudian diberikan simvastatin 0,20 mg/kg selama 14 hari. Kelompok kontrol negatif hanya diberikan pakan dan air. Hasil penelitian memperlihatkan rerata kadar kolesterol total tikus Wistar setelah diberikan 125 mg/kg dan 250 mg/kg ekstrak biji alpukat menurun sebesar 18,1% dan 31,2%. Simpulan: Ekstrak biji Alpukat berefek menurunkan kadar kolesterol total pada tikus Wistar.Kata kunci: biji alpukat, kadar kolesterol total

scholarly journals Comparative Effectiveness of Corn Oil (Zea mays) with Pure Coconut Oil (Cocos nucifera L.) to Reduced Glucose Blood Levels of Alloxane Injected Wistar Rats

2017 ◽  
Vol 3 (3) ◽  
pp. 50
Author(s):  
Khadijah Nur Al Firdausi ◽  
Sugiyanta Sugiyanta ◽  
Pipiet Wulandari
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Wistar Rats ◽  
Corn Oil ◽  
Cocos Nucifera ◽  
Coconut Oil ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Cocos Nucifera L

Epidemiological studies show an increased incidence of diabetes mellitus. The initial therapy of diabetes mellitus is a diet treatment. The recommended intake of fat is a Saturated Fatty Acids (SFA) <7% and a Polyunsatturated Fatty Acid (PUFA) <10% of calories. The corn oil contains PUFA and the virgin coconut oil contains SFA as the main component. Aims of this study was to compare the effectivity of corn oil (Zea mays) and virgin coconut oil (Cocos nucifera L.) in decreasing blood glucose level in alloxane-ijnected wistar rats. This was a laboratory experiment research, used the posttest-only control design. The negative control group was wistar rats injected by aquabidest and standard feed diet (K-); the positive control group was alloxane-injected rats with standard feed diet (K+); alloxane-injected rats with standard food diet and 0.54 mL of corn oil/day for 28 days were P1 group; alloxane-injected rats with standard diet food and 0.54 mL of virgin coconut oil/day for 28 days were P2 group. Statistical analysis using the one way ANOVA test showed that the corn oil and virgin coconut oil decrease blood glucose level, but there was no significantly difference in decresing of blood glucose level between P1 and P2. This study concluded that the corn oil and the virgin coconut oil have the same effectiveness in decreasing blood glucose level in wistar rats injected with alloxane.Keywords: Corn oil, virgin coconut oil, blood glucose level, alloxane

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Patients Living With HIV Are Less Likely to Receive Appropriate Statin Therapy for Cardiovascular Disease Risk Reduction

2021 ◽  
pp. 089719002199979
Author(s):  
Roshni P. Emmons ◽  
Nicholas V. Hastain ◽  
Todd A. Miano ◽  
Jason J. Schafer
Keyword(s):  
Cardiovascular Disease ◽  
Logistic Regression ◽  
Statin Therapy ◽  
Risk Reduction ◽  
Blood Cholesterol ◽  
Control Group ◽  
Atherosclerotic Cardiovascular Disease ◽  
Ascvd Risk ◽  
Living With Hiv ◽  
To Receive

Background: Recent studies suggest that statins are underprescribed in patients living with HIV (PLWH) at risk for atherosclerotic cardiovascular disease (ASCVD), but none have assessed if eligible patients receive the correct statin and intensity compared to uninfected controls. Objectives: The primary objective was to determine whether statin-eligible PLWH are less likely to receive appropriate statin therapy compared to patients without HIV. Methods: This retrospective study evaluated statin eligibility and prescribing among patients in both an HIV and internal medicine clinic at an urban, academic medical center from June-September 2018 using the American College of Cardiology/American Heart Association guideline on treating blood cholesterol to reduce ASCVD risk. Patients were assessed for eligibility and actual treatment with appropriate statin therapy. Characteristics of patients appropriately and not appropriately treated were compared with chi-square testing and predictors for receiving appropriate statin therapy were determined with logistic regression. Results: A total of 221/300 study subjects were statin-eligible. Fewer statin-eligible PLWH were receiving the correct statin intensity for their risk benefit group versus the uninfected control group (30.2% vs 67.0%, p < 0.001). In the multivariable logistic regression analysis, PLWH were significantly less likely to receive appropriate statin therapy, while those with polypharmacy were more likely to receive appropriate statin therapy. Conclusion: Our study reveals that PLWH may be at a disadvantage in receiving appropriate statin therapy for ASCVD risk reduction. This is important given the heightened risk for ASCVD in this population, and strategies that address this gap in care should be explored.

scholarly journals PENGARUH APLIKASI VIRGIN COCONUT OIL TERHADAP PENINGKATAN JUMLAH FIBROBLAS PADA LUKA PASCA PENCABUTAN GIGI PADA RATTUS NOVERGICUS

2015 ◽  
Vol 1 (2) ◽  
pp. 29
Author(s):  
Anggun Hibah Jannah Tamara ◽  
Yayun Siti Rochmah ◽  
Rochman Mujayanto
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Health Benefit ◽  
Coconut Oil ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Complex Biological Process ◽  
Significant Difference ◽  
Per Oral ◽  
Levene Test

Background: Wound healing is a complex biological process. Fibroblast is one of cell which is responsible for the wound healing process. Virgin Coconut Oil (VCO) have health benefit as antibacterial, antiinflamatory, antioxidant, and immunomodulatory. This research was purposed to know the influence use of VCO over the amount of fibroblast in wound healing after dental extraction.Method: Research quasi experimental with post test control group design and using 15 Rattus novergicus which were divided into three groups (control positive, VCO topical application, and VCO per oral application). Tooth removal was committed by using explorer, scalpel-blade, and arterial clamp. Then VCO applied everyday for 7 days. Day 7th Rattus novergicus were died, the socket after extraction were made into histological form, then the amount of fibroblast were counted with 5 field of views and made in average. Result: The number of fibroblast of the most numerous was VCO per oral ( 48,6 ± 49,8 ), VCO topical ( 36,2 ± 38,8 ), and control positive ( 33,4 ± 35,2 ). The results of the Saphiro Wilk test and Levene test acquired data normally distributed and homogeny, so it continued to One Way Anova and data showed there were significant difference among the groups of samples with value p<0,05.Conclusion: The conclusion of this research is VCO could increase the number of fibroblasts in wound healing after dental extractions

scholarly journals The Effect of Virgin Coconut Oil (VCO) with Lotion On The Skin Moisture among Uremic Patients Undergoing Hemodialysis in Hospital Binjai City, Indonesia

2020 ◽  
Vol 3 (5) ◽  
pp. 560-568
Author(s):  
Siti Saodah ◽  
Imam Budi Putra ◽  
Cholina Trisa S
Keyword(s):  
Kidney Failure ◽  
Intervention Group ◽  
Coconut Oil ◽  
Chronic Kidney Failure ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Before And After ◽  
Post Test ◽  
Uremic Patients ◽  
Skin Moisture

Chronic kidney failure is a public health problem throughout the world, and the number of sufferers is increasing. Chronic kidney failure can cause clinical symptoms in various body systems, one of which is a disorder in the skin that becomes dry (uremic). This study aimed to examine the effect of Virgin Coconut Oil (VCO) on the skin moisture among uremic patients undergoing hemodialysis. This type of research is a quasi-experiment with pre-test and post-test equivalent control group. The study was conducted at the Regional General Hospital, Dr. RM. Djoelham Binjai. The study population was 80 people, divided into 2 sample groups of 40 people each. The results showed that there was a significant effect of skin moisture on the intervention group before and after being given Virgin Coconut Oil, p = 0.000<0.05; There was a significant effect of skin moisture in the control group before and after lotion (post-test), p = 0.000<0.05. There is no need for special emulsions such as VCO to moisturize the skin in uremic patients undergoing hemodialysis because using ordinary lotions can moisturize the skin. It must be used regularly, twice a day after bathing. The lotion used must also be a lotion that does not contain mercury and chemicals that can harm the skin. To increase the skin's moisture becomes normal, giving lotion is better than VCO because by providing lotion, more skin becomes normal, while using VCO, the skin becomes more oily. It is recommended to health workers (doctors, nurses) to practice correctly and appropriately how to administer Virgin Coconut Oil (VCO) to uremic patients undergoing hemodialysis to be done at home

scholarly journals Evaluation of Kidney Function Parameters in Diabetic Rats Following Virgin Coconut Oil Diet

Folia Medica ◽  
2019 ◽  
Vol 61 (2) ◽  
pp. 249-257 ◽  
Author(s):  
Akinjide M. Akinnuga ◽  
Olubayode Bamidele ◽  
Anthony J. Adewumi
Keyword(s):  
Kidney Function ◽  
Biochemical Analysis ◽  
Coconut Oil ◽  
Diabetic Rats ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Normal Rat ◽  
Group 2 ◽  
Diabetes Control Group ◽  
Group 1

Abstract Background: Diabetes mellitus (DM) leads to disruption of kidney function parameters (KFPs) which are markers of kidney diseases, especially nephropathy. Virgin coconut oil (VCO) has been implicated in playing a significant role in DM management. However, its role on KFPs in DM is scarce. Aim: To evaluate the kidney function parameters following VCO diet in diabetic rats. Materials and methods: : Twenty-five (25) male rats of 150 – 200 g were divided into 5 groups (n=5): Non-diabetic control (Group 1), diabetes control (Group 2), diabetes + metformin (Group 3), diabetes + 10% VCO (Group 4) and diabetes + 20% VCO (Group 5). Apart from Group 1, other groups were given intraperitone-ally 50 mg/kg of streptozotocin to induce diabetes mellitus. After 72 hours, fasting hyperglycaemia was confirmed by glucose oxidase method. All the rats were fed normal rat chow for 8 weeks. At 8th week, serum and urine samples were analysed for biochemical analysis. After 8 weeks, Group 1 and Group 2 continued to be fed on normal rat chow while other groups were treated with diets (VCO) or drug (metformin) for 4 weeks. At 12th week, urine samples were collected for biochemical analysis, the rats were sacrificed, and blood samples were collected by cardiac puncture. Results: There were significant differences in some KFPs in diabetes control (Group 2) compared to other experimental groups. However, there was no significant difference in glomerular filtration rate (GFR) and serum sodium in all the groups. Conclusion: VCO supplementary diet improved the altered KFPs and could be a therapy for kidney problems.

Effect of Prunus Dulcis & Álpha-Tocopherol in Ethanol Induced Dyslipidemia In Wistar Rats

2020 ◽  
Vol 13 (4) ◽  
pp. 1619-1624
Author(s):  
Samuel Sundar Doss ◽  
J. Vijayakumar ◽  
E. Sukumar ◽  
K. Rekha
Keyword(s):  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Prunus Dulcis ◽  
Alpha Tocopherol ◽  
Control Group ◽  
P Value ◽  
Low Density ◽  
Ethanol Group ◽  
Beneficial Effects

The study is aimed at assessing the effect of Prunus dulcis and alpha-tocopherol treatment against ethanol induced dyslipidemia in Wistar rats. 30 albino Wistar rats were selected based on the selection criteria and equally distributed into 5 groups – Control, ethanol, Prunus dulcis, alpha-tocopherol and combination of alpha-tocopherol + Prunus dulcis treated for 40 days. After the treatment for 40 days, all the animals were euthanized and a retro-orbital puncture was made to collect the blood samples for biochemical investigations. Obtained results were statistically analysed using ANOVA. Compared to ethanol group alpha tocopherol, Prunus dulcis and alpha tocopherol + Prunus dulcis treatment significantly decreased total cholesterol and triglycerides levels with p value <0.001. High density lipoprotein (66.31%) levels in the ethanol group were decreased compared to the control group and were significantly increased in other groups. Low density lipoprotein and Very low density lipoprotein levels were higher in the ethanol group compared with the control group and were significantly reduced in other groups with p value <0.001. Results suggest that ethanol has an ill effect on the lipid profile. Treatment with Prunus dulcius and alpha-tocopherol both solely or in combination has produced beneficial effects against dyslipidemia.

scholarly journals The Effects of Virgin Coconut Oil on Bone Oxidative Status in Ovariectomised Rat

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Mouna Abdelrahman Abujazia ◽  
Norliza Muhammad ◽  
Ahmad Nazrun Shuid ◽  
Ima Nirwana Soelaiman
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Rat Model ◽  
Coconut Oil ◽  
Antioxidant Property ◽  
Oxidative Status ◽  
Control Group ◽  
Normal Female ◽  
Sprague Dawley ◽  
Virgin Coconut Oil

Virgin coconut oil (VCO) was found to have antioxidant property due to its high polyphenol content. The aim of this study was to investigate the effect of the virgin coconut oil on lipid peroxidation in the bone of an osteoporotic rat model. Normal female Sprague-Dawley rats aged 3 months old were randomly divided into 4 groups, with 8 rats in each group: baseline, sham, ovariectomised (OVX) control group, and OVX given 8% VCO in the diet for six weeks. The oxidative status of the bone was assessed by measuring the index of lipid peroxidation, which is malondialdehyde (MDA) concentration, as well as the endogenous antioxidant enzymes glutathione peroxidase (GPX) and superoxide dismutase (SOD) in the tibia at the end of the study. The results showed that there was a significant decrease in MDA levels in the OVX-VCO group compared to control group. Ovariectomised rats treated with VCO also had significantly higher GPX concentration. The SOD level seemed to be increased in the OVX-VCO group compared to OVX-control group. In conclusion, VCO prevented lipid peroxidation and increased the antioxidant enzymes in the osteoporotic rat model.

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