Antioxidant, anti‐inflammatory, and antiapoptotic effects of virgin coconut oil against antibiotic drug gentamicin‐induced nephrotoxicity via the suppression of oxidative stress and modulation of iNOS/NF‐ĸB/caspase‐3 signaling pathway in Wistar rats

2019 ◽  
Vol 44 (1) ◽  
Author(s):  
Ademola C. Famurewa ◽  
Ekenechukwu K. Maduagwuna ◽  
Abiola M. Folawiyo ◽  
Elizabeth E. Besong ◽  
Albert N. Eteudo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Wistar Rats ◽  
Caspase 3 ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Antibiotic Drug ◽  
Anti Inflammatory

scholarly journals Enhanced memory in Wistar rats by virgin coconut oil is associated with increased antioxidative, cholinergic activities and reduced oxidative stress

2017 ◽  
Vol 55 (1) ◽  
pp. 825-832 ◽  
Author(s):  
Nur Syafiqah Rahim ◽  
Siong Meng Lim ◽  
Vasudevan Mani ◽  
Abu Bakar Abdul Majeed ◽  
Kalavathy Ramasamy
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Coconut Oil ◽  
Virgin Coconut Oil

scholarly journals Antioxidant and anti-inflammatory mechanisms of polyphenols isolated from virgin coconut oil attenuate cadmium-induced oxidative stress-mediated nephrotoxicity and inflammation in rats

2018 ◽  
Vol 16 (4) ◽  
pp. 281-288 ◽  
Author(s):  
Ademola C. Famurewa ◽  
Abumchukwu J. Ejezie ◽  
Chioma S. Ugwu-Ejezie ◽  
Ebele J. Ikekpeazu ◽  
Fidelis E. Ejezie
Keyword(s):  
Oxidative Stress ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Anti Inflammatory

scholarly journals FORMULASI NANOEMULSI ASPIRIN MENGGUNAKAN ETANOL 96 % SEBAGAI KO-SURFAKTAN

WARTA FARMASI ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 1-11
Author(s):  
Nur Saadah Daud ◽  
Musdalipah Musdalipah ◽  
Asriyanti Lamadari
Keyword(s):  
Oral Administration ◽  
Pain Therapy ◽  
Coconut Oil ◽  
Tween 80 ◽  
Moderate Pain ◽  
Virgin Coconut Oil ◽  
Cycling Test ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
20 Nm

ABSTRAK Aspirin termasuk dalam golongan Non Steroidal Anti Inflammatory Drugs (NSAIDs) yang banyak digunakan pada pengobatan nyeri ringan sampai sedang, antipiretik, anti inflamasi, serta anti koagulan. Pada penggunaan secara oral dapat menurunkan efektifitas obat akibat metabolisme lintas pertama. Alternatif untuk mengatasi masalah tersebut yaitu membuat sediaan topikal nanoemulsi aspirin. Nanoemulsi yaitu sistem emulsi yang transparan, tembus cahaya dan merupakan d ispersi minyak air yang distabilkan oleh lapisan film dari surfaktan dan ko-surfaktan, yang memiliki ukuran droplet 20 nm-500 nm. Penelitian ini bertujuan untuk membuat nanoemulsi aspirin dengan variasi konsentrasi etanol 96 % sebagai ko-surfaktan. Nanoemulsi aspirin dibuat dengan Virgin Coconut Oil (VCO) sebagai fase minyak, tween 80 sebagai surfaktan,dan etanol 96 % sebagai ko-surfaktan. Hasil penelitian mendapatkan 5 formula nanoemulsi jernih beraroma khas dengan nilai pH berkisar pada range 4,0-4,5 yang telah memenuhi pH normal kulit. dengan konsentrasi etanol 96 % yaitu 10 %, 15 %, 20 %, 25 % dan 30 %, dan dibuat 3 replikasi. Hasil uji stabilitas fisik menunjukkan bahwa kelima formula menghasilkan nanoemulsi yang stabil dan tidak terjadi pemisahan fase sesudah uji sentrifugasi dan cycling test dilakukan. Kata Kunci     : Nanoemulsi, Aspirin, Etanol 96%, Ko-surfaktan   ABSTRACT Acetosal known to be a part of the group medications called Non Steroidal Anti Inflammatory Drugs (NSAIDs) that was used for mild to moderate pain therapy, antipyretic, anti inflamation and anti coagulan. Oral administration of acetosal may decrease its effectiveness because of the first past metabolism problem. The purpose of this study was to formulate acetosal into nanoemulsion form for topical preparation as an alternative to avoid those problem with ethanol 96% as co-surfactant.  Nanoemulsion was an emultion system which transparent, glasslike, and comes from dispertion of water and oil stabilized by film-coated that made from surfactant and co-surfactant combination, which has droplet size around 20 nm-500 nm. Acetosal nanoemulsions were prepared with Virgin Coconut Oil (VCO) as oil phase, tween 80 as surfactant and ethanol 96 % as co-surfactant. There were 5 formulas of transparent acetosal nanoemultion. Their yield of pH were about 4,0-4,5 were met the normal skin’s pH. They were acetosal nanoemulsions with ethanol 96 % of 10%, 15%, 20%, 25%, and 30%. These five were stable and did not show the separation of phase after both centrifugation and cycling test. Keyword          : Nanoemulsion, Acetosal, Ethanol 96%, Co-Surfactan

Virgin coconut oil enhances neuroprotective and anti‐inflammatory factors in the thymus and mesenteric lymph nodes of rats

2019 ◽  
Vol 11 (1) ◽  
pp. 65-72
Author(s):  
Sunil Karrunanithi ◽  
Kishore A. Ravichandran ◽  
Lalgi Hima ◽  
Uday P. Pratap ◽  
Ramasamy Vasantharekha ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Coconut Oil ◽  
Inflammatory Factors ◽  
Virgin Coconut Oil ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Anti Inflammatory

scholarly journals In vitro anti-inflammatory and skin protective properties of Virgin coconut oil

2019 ◽  
Vol 9 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Sandeep R. Varma ◽  
Thiyagarajan O. Sivaprakasam ◽  
Ilavarasu Arumugam ◽  
N. Dilip ◽  
M. Raghuraman ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Protective Properties ◽  
Anti Inflammatory

scholarly journals Methane Alleviates Acetaminophen-Induced Liver Injury by Inhibiting Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis through the Nrf2/HO-1/NQO1 Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Yang Feng ◽  
Ruixia Cui ◽  
Zeyu Li ◽  
Xia Zhang ◽  
Yifan Jia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Liver Injury ◽  
Endoplasmic Reticulum Stress ◽  
Signaling Pathway ◽  
Hepatic Injury ◽  
Protective Effects ◽  
Serum Aminotransferase ◽  
Anti Inflammatory

Acetaminophen- (APAP-) induced hepatic injury is an important clinical challenge. Oxidative stress, inflammation, apoptosis, and endoplasmic reticulum stress (ERS) contribute to the pathogenesis. Methane has potential anti-inflammatory, antioxidant, and antiapoptotic properties. This project was aimed at studying the protective effects and relative mechanisms of methane in APAP-induced liver injury. In the in vivo experiment, C57BL/6 mice were treated with APAP (400 mg/kg) to induce hepatic injury followed by methane-rich saline (MRS) 10 ml/kg i.p. after 12 and 24 h. We observed that MRS alleviated the histopathological lesions in the liver, decreased serum aminotransferase levels, reduced the levels of inflammatory cytokines, suppressed the nuclear factor-κB expression. Further, we found that MRS relieved oxidative stress by regulating the Nrf2/HO-1/NQO1 signaling pathway and their downstream products after APAP challenge. MRS also regulated proteins associated with ERS-induced apoptosis. In the in vitro experiment, the L-02 cell line was treated with APAP (10 mM) to induce hepatic injury. We found that a methane-rich medium decreased the levels of reactive oxygen species (DHE fluorescent staining), inhibited apoptosis (cell flow test), and regulated the Nrf2/HO-1/NQO1 signaling pathway. Our data indicated that MRS prevented APAP-induced hepatic injury via anti-inflammatory, antioxidant, anti-ERS, and antiapoptotic properties involving the Nrf2/HO-1/NQO1 signaling pathway.

scholarly journals Activation of the Nrf2/HO-1 Pathway by Amomum villosum Extract Suppresses LPS-Induced Oxidative Stress In Vitro and Ex Vivo

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Dong-Woo Lim ◽  
Hee-Jin Choi ◽  
Sun-Dong Park ◽  
Hyuck Kim ◽  
Ga-Ram Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Inflammatory Responses ◽  
Ethanol Extract ◽  
Peritoneal Macrophages ◽  
Raw 264.7 Cells ◽  
Heme Oxygenase 1 ◽  
Raw 264.7 ◽  
Related Factor ◽  
Anti Inflammatory

Despite its deleterious effects on living cells, oxidative stress plays essential roles in normal physiological processes and provides signaling molecules for cell growth, differentiation, and inflammation. Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages. We investigated the effects of ethanol extract of A. villosum (AVEE) on lipopolysaccharide- (LPS-) stimulated inflammatory responses generated via the Nrf2/HO-1 signaling pathway in murine peritoneal macrophages and RAW 264.7 cells. AVEE was found to suppress the NF-κB signaling pathway, thus, to reduce proinflammatory cytokine, nitric oxide, and prostaglandin levels in peritoneal macrophages and Raw 264.7 cells treated with LPS, and to enhance HO-1 expression by activating Nrf2 signaling. Furthermore, these anti-inflammatory effects of AVEE were diminished when cells were pretreated with SnPP (a HO-1 inhibitor). HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway. These results show A. villosum ethanol extract exerts anti-inflammatory effects by activating the Nrf2/HO-1 pathway in LPS-stimulated macrophages.

Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats

2019 ◽  
Vol 35 (4) ◽  
pp. 955-968 ◽  
Author(s):  
Mashoque Ahmad Rather ◽  
Arokiasamy Justin-Thenmozhi ◽  
Thamilarasan Manivasagam ◽  
Chidambaram Saravanababu ◽  
Gilles J. Guillemin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Aluminum Chloride ◽  
Wistar Rats ◽  
Asiatic Acid ◽  
Tau Pathology ◽  
Gsk 3Β

Azelaic Acid Dry Emulsion

2014 ◽  
Vol 1060 ◽  
pp. 29-32
Author(s):  
Somlak Kongmuang ◽  
Khaw-on Tepsukon ◽  
Pawitra Yodwandee ◽  
Porntipa Laovanichkul
Keyword(s):  
Coconut Oil ◽  
Angle Of Repose ◽  
Particle Sizes ◽  
Drying Process ◽  
Virgin Coconut Oil ◽  
Powder Mixing ◽  
Oil Emulsion ◽  
Antibiotic Drug ◽  
Dry Emulsion ◽  
Acne Treatment

Azelaic (AZ) acid is a non antibiotic drug used for an acne treatment. The AZ dry emulsion power was prepared by mixing power of AZ with dry emulsion base. The 20% AZ cream was obtained by addition of water into powder mixture with a ratio of 1:1 by weight. The dry emulsion base consisted of virgin coconut oil with an emulsifier, hydroxyproplymethylcellulose (HPMC). The physical properties of each primary coconut oil emulsion (COE) were evaluated as percent creaming, theirs viscosity and particle sizes. The results were shown that the emulsion system of 7.5% HPMC provided the suitable formulas with oil droplet particle size 1.23 ± 8.15 micrometer and its viscosity of 30405.02 ± 480.58 cps. After drying process, the moisture content of coconut oil dry emulsion (CODE) was 2.94%. The yield percentage of dry powder was 58%. Moreover, the flowability of dry emulsion powder was appeared to be fair (with an angle of repose of 35.35). After dry emulsion powder mixing with 20 % AZ and water, the AZ cream was appeared to be stable for at least one week with no significantly different in pH and amount of AZ. Thus AZ dry emulsion preparation could be used an alternative recipe for acne treatment with good stability during one week after reconstitution.

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