A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression

Sophia So Ngo Lam; Carman Ka Man Ip; Abby Sin Chi Mak; Alice Sze Tsai Wong

doi:10.18632/oncotarget.9345

A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression

Oncotarget ◽

10.18632/oncotarget.9345 ◽

2016 ◽

Vol 7 (25) ◽

pp. 38064-38077 ◽

Cited By ~ 5

Author(s):

Sophia So Ngo Lam ◽

Carman Ka Man Ip ◽

Abby Sin Chi Mak ◽

Alice Sze Tsai Wong

Keyword(s):

Ovarian Cancer ◽

Cancer Progression ◽

Multicellular Spheroid ◽

Spheroid Formation ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Microrna Biogenesis

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Novel functions for P70 S6 kinase : regulation of microRNA biogenesis and multicellular spheroid formation of ovarian cancer cells

10.5353/th_b5719450 ◽

2016 ◽

Author(s):

So-ngo Lam

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Ovarian Cancer Cells ◽

Multicellular Spheroid ◽

Spheroid Formation ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Microrna Biogenesis ◽

Kinase Regulation

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p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation

Oncotarget ◽

10.18632/oncotarget.2362 ◽

2014 ◽

Vol 5 (19) ◽

pp. 9133-9149 ◽

Cited By ~ 17

Author(s):

Carman Ka Man Ip ◽

Susan Yung ◽

Tak-Mao Chan ◽

Sai-Wah Tsao ◽

Alice Sze Tsai Wong

Keyword(s):

Ovarian Cancer ◽

Cancer Metastasis ◽

Integrin Signaling ◽

Β1 Integrin ◽

Multicellular Spheroid ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Signaling Activation

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MEK1-independent activation of MAPK and MEK1-dependent activation of p70 S6 kinase by stem cell factor (SCF) in ovarian cancer cells

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2009.03.031 ◽

2009 ◽

Vol 382 (2) ◽

pp. 385-389 ◽

Cited By ~ 4

Author(s):

Lian Liu ◽

Xin Zhang ◽

Chao Du ◽

Xiaoning Zhang ◽

Nan Hou ◽

...

Keyword(s):

Ovarian Cancer ◽

Stem Cell ◽

Cancer Cells ◽

Stem Cell Factor ◽

Ovarian Cancer Cells ◽

S6 Kinase ◽

P70 S6 Kinase

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Exploiting p70 S6 kinase as a target for ovarian cancer

Expert Opinion on Therapeutic Targets ◽

10.1517/14728222.2012.684680 ◽

2012 ◽

Vol 16 (6) ◽

pp. 619-630 ◽

Cited By ~ 26

Author(s):

Carman KM Ip ◽

Alice ST Wong

Keyword(s):

Ovarian Cancer ◽

S6 Kinase ◽

P70 S6 Kinase

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Paclitaxel Resistance and Multicellular Spheroid Formation Are Induced by Kallikrein-Related Peptidase 4 in Serous Ovarian Cancer Cells in an Ascites Mimicking Microenvironment

PLoS ONE ◽

10.1371/journal.pone.0057056 ◽

2013 ◽

Vol 8 (2) ◽

pp. e57056 ◽

Cited By ~ 36

Author(s):

Ying Dong ◽

Carson Stephens ◽

Carina Walpole ◽

Joakim E. Swedberg ◽

Glen M. Boyle ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Ovarian Cancer Cells ◽

Serous Ovarian Cancer ◽

Multicellular Spheroid ◽

Spheroid Formation ◽

Paclitaxel Resistance

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p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells

Oncogene ◽

10.1038/onc.2010.615 ◽

2011 ◽

Vol 30 (21) ◽

pp. 2420-2432 ◽

Cited By ~ 67

Author(s):

C K M Ip ◽

A N Y Cheung ◽

H Y S Ngan ◽

A S T Wong

Keyword(s):

Ovarian Cancer ◽

Actin Cytoskeleton ◽

Cancer Cells ◽

Ovarian Cancer Cells ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Directed Migration ◽

Cytoskeleton Dynamics

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Abstract 5116: p70 S6 kinase regulates the actin cytoskeleton in ovarian cancer cell motility by binding and cross-linking actin filaments

10.1158/1538-7445.am10-5116 ◽

2010 ◽

Author(s):

Carman Ka Man Ip ◽

Alice S. T. Wong

Keyword(s):

Ovarian Cancer ◽

Actin Cytoskeleton ◽

Cell Motility ◽

Cancer Cell ◽

Actin Filaments ◽

Ovarian Cancer Cell ◽

Cross Linking ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Cancer Cell Motility

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Abstract 1984: Activated BMP signalling modulates multicellular spheroid formation and reattachment of ascites-derived human epithelial ovarian cancer cells in an in vitro model of metastasis

10.1158/1538-7445.am2011-1984 ◽

2011 ◽

Author(s):

Teresa M. Peart ◽

Monique Bertrand ◽

Michel Prefontaine ◽

Akira Sugimoto ◽

Gabriel DiMattia ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Cancer Cells ◽

In Vitro Model ◽

Ovarian Cancer Cells ◽

Multicellular Spheroid ◽

Spheroid Formation ◽

Vitro Model ◽

Bmp Signalling

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Abstract 1527: Hepatocyte growth factor modulates adhesion of ovarian cancer cells to the peritoneum mesothelium through p70 S6 kinase

10.1158/1538-7445.am2011-1527 ◽

2011 ◽

Author(s):

Carman K.M Ip ◽

Susan Yung ◽

Tak-Mao Chan ◽

Alice S.T. Wong

Keyword(s):

Ovarian Cancer ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Cancer Cells ◽

Ovarian Cancer Cells ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Hepatocyte Growth

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Transcriptional regulation of metastasis-related genes matrix metalloproteinase-9 and Snail by p70 S6 kinase in ovarian cancer cells

10.5353/th_b4590268 ◽

2011 ◽

Author(s):

Ho Pak

Keyword(s):

Ovarian Cancer ◽

Transcriptional Regulation ◽

Matrix Metalloproteinase ◽

Cancer Cells ◽

Matrix Metalloproteinase 9 ◽

Ovarian Cancer Cells ◽

S6 Kinase ◽

P70 S6 Kinase ◽

Metalloproteinase 9

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