scholarly journals Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 24908-24927 ◽  
Author(s):  
Charles Saby ◽  
Emilie Buache ◽  
Sylvie Brassart-Pasco ◽  
Hassan El Btaouri ◽  
Marie-Pierre Courageot ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Type I Collagen ◽  
Growth Suppression ◽  
Type I ◽  
Tumor Cell Growth ◽  
Discoidin Domain Receptor ◽  
Discoidin Domain Receptor 2 ◽  
Cell Growth Suppression

Tumor Cell Growth Suppression by Chalcone (1,3-Diphenyl-2-Propen-l-One)

1997 ◽  
Vol 12 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Hideo Kamei ◽  
Tatsurou Koide ◽  
Yoko Hashimoto ◽  
Takashi Kojima ◽  
Makoto Hasegawa
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Suppression ◽  
Tumor Cell Growth ◽  
Cell Growth Suppression

Tumor Cell Growth Suppression by Tannic Acid

1999 ◽  
Vol 14 (2) ◽  
pp. 135-138 ◽  
Author(s):  
Hideo Kamei ◽  
Tatsurou Koide ◽  
Yoko Hashimoto ◽  
Takashi Kojima ◽  
Makoto Hasegawa
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Tannic Acid ◽  
Growth Suppression ◽  
Tumor Cell Growth ◽  
Cell Growth Suppression

scholarly journals Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression

Oncogene ◽  
2001 ◽  
Vol 20 (55) ◽  
pp. 7935-7944 ◽  
Author(s):  
Dongmei Zhang ◽  
Scott Vuocolo ◽  
Valeria Masciullo ◽  
Teodoro Sava ◽  
Antonio Giordano ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Ovarian Tumor ◽  
Growth Suppression ◽  
Tumor Cell Growth ◽  
Cell Cycle Genes ◽  
Ovarian Tumor Cell ◽  
Cell Growth Suppression

scholarly journals Enhanced tumor cell growth suppression by an N-terminal truncated retinoblastoma protein.

1994 ◽  
Vol 91 (21) ◽  
pp. 9837-9841 ◽  
Author(s):  
H. J. Xu ◽  
K. Xu ◽  
Y. Zhou ◽  
J. Li ◽  
W. F. Benedict ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Retinoblastoma Protein ◽  
Growth Suppression ◽  
Tumor Cell Growth ◽  
Cell Growth Suppression

scholarly journals Analysis of wild-type and mutant p21WAF-1 gene activities.

1996 ◽  
Vol 16 (4) ◽  
pp. 1786-1793 ◽  
Author(s):  
J Lin ◽  
C Reichner ◽  
X Wu ◽  
A J Levine
Keyword(s):  
Amino Acid ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cyclin D1 ◽  
Cyclin E ◽  
Growth Suppression ◽  
Nuclear Antigen ◽  
Tumor Cell Growth ◽  
Amino Acid Residues ◽  
Wild Type

The p21WAF-1 gene is positively regulated by the wild-type p53 protein. p21WAF-1 has been shown to interact with several cyclin-dependent kinase complexes and block the activity of G1 cyclin-dependent kinases (cdks). Mutational analysis with the p21WAF-1 gene localized a site, at amino acid residues 21 and 24 in the amino terminus of the protein, for p21WAF-1 binding to cyclins D and E. This region of the protein is conserved (residues 21 to 26) in other p21WAF-1 family members, p27kip-1 and p57kip-2. The same p21WAF-121,24 mutant also fails to bind to cyclin D1-cdk 4 or cyclin E-cdk 2 complexes in vitro, suggesting that amino acid residues 21 and 24 are important for p21WAF-1-cdk-cyclin trimeric complex interactions. The p21WAF-1 wild-type protein will suppress tumor cell growth in culture while p21WAF-1 mutant proteins with defects in residues 21 and 24 fail to suppress tumor cell growth. The overexpression of cyclin D or E in these cells will partially overcome the growth suppression of wild-type p21WAF-1 protein in cells. These results provide evidence that p21WAF-1 acts through cyclin D1-cdk4 and cyclin E-cdk2 complexes in vivo to induce the growth suppression. The p21WAF-1 binding sites for cyclins (residues 21 to 26), cdk2 (residues 49 to 71), and proliferating-cell nuclear antigen (residues 124 to 164) have all been mapped to discrete sites on the protein.

scholarly journals Discoidin Domain Receptor 2 Interacts with Src and Shc following Its Activation by Type I Collagen

2002 ◽  
Vol 277 (21) ◽  
pp. 19206-19212 ◽  
Author(s):  
Kazuo Ikeda ◽  
Li-Hsien Wang ◽  
Richard Torres ◽  
Hong Zhao ◽  
Elvira Olaso ◽  
...  
Keyword(s):  
Type I Collagen ◽  
Type I ◽  
Discoidin Domain Receptor ◽  
Discoidin Domain Receptor 2
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